L-745870 , CAS No.158985-00-3, Antagonist of D 4 receptor

Item Number

L412538

• Synonyms: 158985-00-3 | L-745870 | 3-((4-(4-Chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridine | 3-[[4-(4-chlorophenyl)piperazin-1-yl]methyl]-1H-pyrrolo[2,3-b]pyridine | J3OLN3XSX7 | L 745,870 | CHEMBL267014 | L745870 | 1H-Pyrrolo[2,3-b]pyridine, 3-[[4-(4-chlorophenyl)-
• Specifications & Purity: Moligand™
• Biochemical and Physiological Mechanisms: L-745870 is a high-affinity, selective and orally active antagonist of human dopamine D4 receptor with Ki of 0.43 nM. L-745870 considerably weaker D2 and D3 receptors affinity with Ki of 960 nM and 2300 nM, respectively. L-745870 has excellent brain penet
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: ANTAGONIST
• Mechanism of action: Antagonist of D 4 receptor

Product Description

Information

L-745870 is a high-affinity, selective and orally active antagonist of human dopamine D4 receptor with Ki of 0.43 nM. L-745870 considerably weaker D2 and D3 receptors affinity with Ki of 960 nM and 2300 nM, respectively. L-745870 has excellent brain penetration.