L-755,507 - ≥98%(HPLC), high purity , CAS No.159182-43-1, Agonist of β 3-adrenoceptor

Item Number

L288431

• Synonyms: L755507 | HMS3677M07 | 4-(3-Hexyl-ureido)-N-(4-{2-[2-hydroxy-3-(4-hydroxy-phenoxy)-propylamino]-ethyl}-phenyl)-benzenesulfonamide | 5-fluoropyrimidin-4-one | CP-0074 | (S)-4-(3-hexylureido)-N-(4-(2-(1-hydroxy-2-(4-hydroxyphenoxy)ethylamino)ethyl)phenyl)be
• Specifications & Purity: Moligand™, ≥98%(HPLC)
• Biochemical and Physiological Mechanisms: Potentβ3-adrenergic receptor partial agonist > 1000-fold selective overβ1- andβ2-adrenoceptors (EC50values are 0.43, 580 and > 10000 nM for activation of cloned humanβ3-,β1- andβ2-adrenoceptors respectively). Stimulates lipolysis in rhesus adipocytesin vi
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: AGONIST
• Mechanism of action: Agonist of β 3-adrenoceptor

Product Description

Product description：

L755507 is a derivative of 4-acylaminobenzenesulfonamide.

Application：

L755507 has been shown to enhance CRISPR genome editing efficiency. 

Biochemical mechanism:

L755507 is a potent β3-adrenergic receptor partial agonist with an EC50 value of 0.43 nM for β3 receptors with over 440-fold selectivity for β3 compared to β1 and β2-adrenergic receptor binding. L755507 has been shown to enhance CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs), increasing the efficiency of GFP insertion by 3-fold compared to control cells.

L755507 is found to stimulate the breakdown of lipids in human adipose tissues. L755507 also promotes urinary bladder relaxation.

L755507 is a potent β3-adrenergic receptor partial agonist.