L-755,507 - 10mM in DMSO, high purity , CAS No.159182-43-1

Item Number

L421904

• Synonyms: 159182-43-1 | L755507 | L-755507 | L-755,507 | 4-[[(HEXYLAMINO)CARBONYL]AMINO]-N-[4-[2-[[(2S)-2-HYDROXY-3-(4-HYDROXYPHENOXY)PROPYL]AMINO]ETHYL]PHENYL]-BENZENESULFONAMIDE | CHEMBL12998 | L 755507 | 1-hexyl-3-[4-[[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]et
• Specifications & Purity: Moligand™, 10mM in DMSO
• Biochemical and Physiological Mechanisms: Potentβ3-adrenergic receptor partial agonist > 1000-fold selective overβ1- andβ2-adrenoceptors (EC50values are 0.43, 580 and > 10000 nM for activation of cloned humanβ3-,β1- andβ2-adrenoceptors respectively). Stimulates lipolysis in rhesus adipocytesin vi
• Storage Temp: Store at -80°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™

Product Description

product description：

L755507 is a derivative of 4-acylaminobenzenesulfonamide.

application：

L755507 has been shown to enhance CRISPR genome editing efficiency. 

Biochemical mechanism:

L755507 is a potent β3-adrenergic receptor partial agonist with an EC50 value of 0.43 nM for β3 receptors with over 440-fold selectivity for β3 compared to β1 and β2-adrenergic receptor binding. L755507 has been shown to enhance CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs), increasing the efficiency of GFP insertion by 3-fold compared to control cells.

L755507 is found to stimulate the breakdown of lipids in human adipose tissues. L755507 also promotes urinary bladder relaxation.

L755507 is a potent β3-adrenergic receptor partial agonist.