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G protein-coupled receptors (GPCRs)
Tachykinin receptors
L 760735 - ≥99%(HPLC), high purity , CAS No.188923-01-5, Antagonist of NK 1 receptor

L 760735 - ≥99%(HPLC), high purity , CAS No.188923-01-5, Antagonist of NK 1 receptor

Item Number

L287080

Grouped product items
SKU	Size	Availability	Price	Qty
L287080-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$250.90
L287080-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$997.90

High affinity NK1antagonist

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Basic Description

Synonyms	J-012179 \| CS-0028948 \| DTXSID30430977 \| UNII-E4C3XGZ4U7 \| 1-(4-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,3-triazol-5-yl)-N,N-dimethylmethanamine hydrochloride \| L 760735 \| E4C3XGZ4U7 \| 1-[5-[[(
Specifications & Purity	Moligand™, ≥99%(HPLC)
Biochemical and Physiological Mechanisms	High affinity NK1receptor antagonist (IC50= 0.19 nM at human NK1receptors). Selective (>300-fold) over h-NK2and h-NK3receptors. Exhibits anxiolytic and antidepressant-like effects. Orally active.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of NK 1 receptor

TACR1 Tclin Substance-P receptor (1 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IUPAC Name	1-[5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-2H-triazol-4-yl]-N,N-dimethylmethanamine;hydrochloride
INCHI	InChI=1S/C26H28F7N5O2.ClH/c1-15(17-10-18(25(28,29)30)12-19(11-17)26(31,32)33)40-24-23(16-4-6-20(27)7-5-16)38(8-9-39-24)14-22-21(13-37(2)3)34-36-35-22;/h4-7,10-12,15,23-24H,8-9,13-14H2,1-3H3,(H,34,35,36);1H/t15-,23+,24-;/m1./s1
InChi Key	VZBKOBSSEVXFNF-QIRDZIKRSA-N
Canonical SMILES	CC(C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)OC2C(N(CCO2)CC3=NNN=C3CN(C)C)C4=CC=C(C=C4)F.Cl
Isomeric SMILES	C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O[C@@H]2[C@@H](N(CCO2)CC3=NNN=C3CN(C)C)C4=CC=C(C=C4)F.Cl
PubChem CID	9809076
Molecular Weight	611.98

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Solubility	Solvent:water, Max Conc. mg/mL: 18.36, Max Conc. mM: 30; Solvent:DMSO, Max Conc. mg/mL: 30.6, Max Conc. mM: 50

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