| Biochemical and Physiological Mechanisms | L-873724 is a potent, orally bioavailable, selective and reversiblenon-basic cathepsin K inhibitor , with IC 50 s of 0.2, 178, 264, and 5239 nM for cathepsin K , cathepsin S , cathepsin L , cathepsin B , respectively. L-873724 also exhibits an I |
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| Product Description | L-873724 is a potent, orally bioavailable, selective and reversible non-basic cathepsin K inhibitor , with IC 50 s of 0.2, 178, 264, and 5239 nM for cathepsin K , cathepsin S , cathepsin L , cathepsin B , respectively L-873724 also exhibits an IC 50 of 0.5 nM for rabbit cathepsin K . L-873724 inhibits bone resorption . In Vitro L-873724 (Compound 22) is a potent and selective non-basic cathepsin K inhibitor, with IC 50 s of 0.2, 178, 264, and 5239 nM for cathepsin K, cathepsin S, cathepsin L, cathepsin B, respectively. L-873724 also shows IC 50 s of 95, 1221 and 4807 nM for Ramos cathepsin S, Hep G2 cathepsin L, Hep G2 cathepsin B. L-873724 exhibits an IC 50 of 0.5 nM for rabbit cathepsin K. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo L-873724 is orally bioavailable, non-lysosomotropic, and efficacious in the rhesus monkey bone resorption model . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 0.2 nM (Cathepsin K), 178 nM (Cathepsin S), 264 nM (Cathepsin B), 5239 nM (Cathepsin B), 0.5 nM (Rabbit cathepsin K) |
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