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L-Alanine - 99%, high purity , CAS No.56-41-7, sodium-coupled neutral amino acid transporter 1;sodium-coupled neutral amino acid transporter 2;sodium-coupled neutral amino acid transporter 4

323 Citations
Item Number
A108263
Grouped product items
SKUSizeAvailabilityPrice Qty
A108263-25g
25g
In stock
$13.90
A108263-100g
100g
In stock
$47.90
A108263-500g
500g
In stock
$215.90
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Glycine receptor agonist

View related series
Flavors and Fragrances sodium-coupled neutral amino acid transporter 1 sodium-coupled neutral amino acid transporter 2 sodium-coupled neutral amino acid transporter 4

Basic Description

Synonyms(S)-Alanine | L-alpha-Aminopropionic acid | alpha-Alanine | 2-Aminopropionic acid | H-Ala-OH | (L)-Alanine | L-2-Aminopropanoic acid | L-alpha-alanine | (S)-2-Aminopropanoic acid | L-2-Aminopropionic acid | L-(+)-Alanine | (2S)-2-Aminopropanoic acid | ala
Specifications & PurityMoligand™, ≥99%
Biochemical and Physiological MechanismsAgonist at the inhibitory glycine receptor.
Storage TempDesiccated
Shipped InNormal
GradeMoligand™
Mechanism of actionsodium-coupled neutral amino acid transporter 1;sodium-coupled neutral amino acid transporter 2;sodium-coupled neutral amino acid transporter 4
Product Description

L-Alanine is a nonessential amino acid that plays a key role in the glucose-alanine cycle between muscle tissue and the liver. In amino acid-degrading tissues such as muscle, amino groups are pooled as glutamate by transamination reactions. The amino group of glutamate is transferred to pyruvate via alanine aminotransferase, forming alanine and α-ketoglutarate. The alanine is passed into the blood and transported to the liver. This reaction is reversed in the liver where pyruvate can be used in gluconeogenesis to form glucose, which may return to other tissues through the circulatory system.
A nonessential amino acid that plays a key role in the glucose-alanine cycle

Associated Targets(Human)

SLC38A2 Tbio Sodium-coupled neutral amino acid transporter 2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SLC38A1 Tbio Sodium-coupled neutral amino acid transporter 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SLC38A4 Tbio Sodium-coupled neutral amino acid transporter 4 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GPRC6A Tchem G-protein coupled receptor family C group 6 member A (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
F2 Tclin Thrombin (11687 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CA2 Tclin Carbonic anhydrase II (17698 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PGR Tclin Progesterone receptor (8562 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AR Tclin Androgen Receptor (11781 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GABRA1 Tclin GABA receptor alpha-1 subunit (399 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GRIN1 Tclin Glutamate (NMDA) receptor subunit zeta 1 (122 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KCNH2 Tclin HERG (29587 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE3A Tclin Phosphodiesterase 3A (3309 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TBXA2R Tclin Thromboxane A2 receptor (5717 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE4A Tclin Phosphodiesterase 4A (1943 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADORA3 Tchem Adenosine A3 receptor (15931 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CA1 Tclin Carbonic anhydrase I (13240 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH3 Tclin Histamine H3 receptor (10389 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KDR Tclin Vascular endothelial growth factor receptor 2 (20924 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FFAR3 Tchem Free fatty acid receptor 3 (304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC36A1 Tchem Proton-coupled amino acid transporter 1 (102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

alr Alanine racemase (2 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CA4 Carbonic anhydrase IV (1713 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pkm Pyruvate kinase isozymes M1/M2 (66 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Escherichia coli (133304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Canis familiaris (36305 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Slc16a10 Monocarboxylate transporter 10 (73 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Slc1a5 Amino acid transporter (271 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name (2S)-2-aminopropanoic acid
INCHI InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1
InChi Key QNAYBMKLOCPYGJ-REOHCLBHSA-N
Canonical SMILES CC(C(=O)O)N
Isomeric SMILES C[C@@H](C(=O)O)N
WGK Germany 1
RTECS AY2990000
Alternate CAS 56-41-7,18875-37-1,25191-17-7,77160-91-9,25191-17-7
PubChem CID 5950
MeSH Entry Terms Abuf\u00e8ne;Alanine;Alanine, L Isomer;Alanine, L-Isomer;L Alanine;L-Alanine;L-Isomer Alanine
Molecular Weight 89.09
Beilstein 1720248
Reaxy-Rn 1720248

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

18 results found

Lot NumberCertificate TypeDateItem
H2414471Certificate of AnalysisJul 29, 2024 A108263
C2421108Certificate of AnalysisApr 09, 2024 A108263
C2427109Certificate of AnalysisMar 14, 2024 A108263
C2427110Certificate of AnalysisMar 14, 2024 A108263
C2427111Certificate of AnalysisMar 14, 2024 A108263
C2427112Certificate of AnalysisMar 14, 2024 A108263
J2312102Certificate of AnalysisJun 09, 2023 A108263
J2312101Certificate of AnalysisJun 09, 2023 A108263
F2328204Certificate of AnalysisJun 09, 2023 A108263
F2328201Certificate of AnalysisJun 09, 2023 A108263
F2328196Certificate of AnalysisJun 09, 2023 A108263
A2305096Certificate of AnalysisJan 17, 2023 A108263
G2203018Certificate of AnalysisJun 08, 2022 A108263
G2203019Certificate of AnalysisJun 08, 2022 A108263
G2203020Certificate of AnalysisJun 08, 2022 A108263
G2203021Certificate of AnalysisJun 08, 2022 A108263
G2203022Certificate of AnalysisJun 08, 2022 A108263
F2306042Certificate of AnalysisJun 08, 2022 A108263

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Chemical and Physical Properties

SolubilitySoluble in water and cold ethanol. Slightly soluble in pyridine. Insoluble in ether and acetone.
Specific Rotation[α]14 ° (C=10, HCl)
Melt Point(°C)314-316°C

Safety and Hazards(GHS)

WGK Germany 1
RTECS AY2990000
Reaxy-Rn 1720248
Merck Index 204

Related Documents

 SDS

 Specification Sheet

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Citations of This Product

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61. Haixing Li, Lingqin Wang, Lijuan Nie, Xiaohua Liu, Jinheng Fu.  (2023)  Sensitivity Intensified Ninhydrin-Based Chromogenic System by Ethanol-Ethyl Acetate: Application to Relative Quantitation of GABA.  Metabolites,  13  (2): (283).  [PMID:36837902] [10.3390/metabo13020283]
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65. Luoming Kang, Airong Li, Yuan Lu, Yuling Ma, Cheng Wang.  (2023)  Experimental study on removal of mercaptans from gas streams by 1-butyl-3-methyl-imidazolyl alanine.  FUEL PROCESSING TECHNOLOGY,  242  (107645).  [PMID:] [10.1016/j.fuproc.2022.107645]
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71. Yufeng Sun, Shengwen Wang, Fangfang Wang, Hao Zhang, Weiya Huang, Aiguo Wu, Yujie Zhang.  (2023)  One-step rapid colorimetric detection of K+ using silver nanoparticles modified by crown ether.  ANALYST,  148  (2): (344-353).  [PMID:36533333] [10.1039/D2AN01840C]
72. Yujiao Tu, Ze Liu, Lei Jiang, Yingying Xiang, Fei Song, Lifen Meng, Xiuling Ji, Lin Yuan.  (2023)  Green ratiometric fluorescent dual-mode nanosensor for highly selective and sensitive detection of new coccine in food.  DYES AND PIGMENTS,  210  (111024).  [PMID:] [10.1016/j.dyepig.2022.111024]
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74. Tingting Li, Guoqiang Guo, Haoming Xing, Yiru Wang, Xinyu Luo, Linfan Wang, Chenjie Gu, Yafei Hou, Da Chen.  (2023)  Energy transfer mediated rapid and visual discrimination of tetracyclines and quercetin in food by using N, Cu Co-doped carbon dots.  ANALYTICA CHIMICA ACTA,  1239  (340706).  [PMID:36628714] [10.1016/j.aca.2022.340706]
75. Ning Lv, Xun Qiu, Qianqian Han, Fengna Xi, Yina Wang, Jun Chen.  (2022)  Anti-Biofouling Electrochemical Sensor Based on the Binary Nanocomposite of Silica Nanochannel Array and Graphene for Doxorubicin Detection in Human Serum and Urine Samples.  MOLECULES,  27  (24): (8640).  [PMID:36557774] [10.3390/molecules27248640]
76. Yuchen Su, Qianghong Zhao, Jiayin Du, Chunlan Liu, Xuemei Jiang, Weili Wei, Xiaoyong Tong.  (2023)  Pickering emulsion-enhanced Vibrio fischeri assay for ecotoxicity assessment of highly hydrophobic polycyclic aromatic hydrocarbons.  CHEMOSPHERE,  313  (137470).  [PMID:36493886] [10.1016/j.chemosphere.2022.137470]
77. Jie Wang, Chenglong Zhao, Feijin Zhou, Hui Lu, Zhenhong Huang, Cheng Yao, Chan Song.  (2022)  Dual mimic enzyme properties of Fe nanoparticles embedded in two-dimensional carbon nanosheets for colorimetric detection of biomolecules.  ANALYST,  148  (1): (146-152).  [PMID:36475531] [10.1039/D2AN01704K]
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90. Chunhua Li, Xiao Xu, Fuli Wang, Yue Zhao, Yubo Shi, Xin Zhao, Jue Liu.  (2023)  Portable smartphone platform integrated with paper strip-assisted fluorescence sensor for ultrasensitive and visual quantitation of ascorbic acid.  FOOD CHEMISTRY,  402  (134222).  [PMID:36130432] [10.1016/j.foodchem.2022.134222]
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101. Zhi-feng Cai, Xian-song Wang, Hao-yang Li, Peng-li Cao, Xin-rui Han, Peng-yu Guo, Fang-yu Cao, Jia-xi Liu, Xue-xue Sun, Tong Li, Ying Wu, Shen Zhang.  (2022)  One-step synthesis of blue emission copper nanoclusters for the detection of furaltadone and temperature.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  279  (121408).  [PMID:35617839] [10.1016/j.saa.2022.121408]
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161. Hao Sun, Weiyun Guo, Yaru Han, Zhifei Gou, Yanmin Liang, Jie Dan, Yi Kang, Jianlong Wang, Wentao Zhang.  (2023)  Food-borne melanoidin based peroxidase mimic for the precise detection of total antioxidant capacity.  MICROCHEMICAL JOURNAL,  184  (108161).  [PMID:] [10.1016/j.microc.2022.108161]
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