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L-Ascorbic acid 6-palmitate - USP grade, high purity , CAS No.137-66-6

6 Citations

PharmPure™

USP

CAS#: 137-66-6
Formula: C₂₂H₃₈O₇
Molecular Weight: 414.53
Beilstein Registry Number: 96552
EC Number: 205-305-4
MDL number: MFCD00005377
PubChem CID: 54680660

Item Number

A104525

Grouped product items
SKU	Size	Availability	Price
A104525-25g	25g	In stock	$50.90
A104525-100g	100g	In stock	$144.90
A104525-500g	500g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$649.90

Ascorbic acid derivative

View related series

Immunology/Inflammation Metabolic Enzyme/Protease NF-κB Reactive Oxygen Species

Basic Description

Synonyms	ASCORBYL PALMITATE [II] \| Ins no.304 \| ASCORBYL PALMITATE \| Ascorbylpalmitic acid \| MFCD00865068 \| CAS-137-66-6 \| DTXSID3041611 \| Nitaxozanid \| 6-O-Palmitoyl-L-ascorbic acid \| ASCORBYL PALMITATE [MART.] \| A0540 \| 6-Palmitoyl-L-ascorbic acid \| QN83US2B0N \|
Specifications & Purity	PharmPure™, USP
Biochemical and Physiological Mechanisms	L-Ascorbyl palmitate (Asc-6P) is used along with other fatty acid ascorbates such as L-ascorbyl oleate and L-ascorbyl linoleate to protect cells and membranes from oxidative damage. Fatty acid ascorbate molecules have increased solubility in non-polar (li
Shipped In	Normal
Grade	PharmPure™, USP
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	L-Ascorbyl palmitate (Asc-6P) is used along with other fatty acid ascorbates such as L-ascorbyl oleate and L-ascorbyl linoleate to protect cells and membranes from oxidative damage. Fatty acid ascorbate molecules have increased solubility in non-polar (lipophilic) environments. It is applied as humectants and emollients.

Associated Targets(Human)

AMY2A Tclin Pancreatic alpha-amylase (74 Activities)

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AMY1A Salivary alpha-amylase (100 Activities)

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RD (1212 Activities)

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APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)

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HSPD1 Tbio HSP60/HSP10 (366 Activities)

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TST Tchem Thiosulfate sulfurtransferase (144 Activities)

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Associated Targets(non-human)

blaZ Beta-lactamase (285 Activities)

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Alpha-chymotrypsin (819 Activities)

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Human alphaherpesvirus 1 (11089 Activities)

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RBL-2H3 (1162 Activities)

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ALP1 Alpha-amylase (16 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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HYAL2 Hyaluronidase (552 Activities)

Discover Target: HYAL2

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groL GroEL/GroES (1042 Activities)

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groEL 60 kDa chaperonin (64 Activities)

Discover Target: groEL

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Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	[(2S)-2-[(2R)-3,4-dihydroxy-5-oxo-2H-furan-2-yl]-2-hydroxyethyl] hexadecanoate
INCHI	InChI=1S/C22H38O7/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(24)28-16-17(23)21-19(25)20(26)22(27)29-21/h17,21,23,25-26H,2-16H2,1H3/t17-,21+/m0/s1
InChi Key	QAQJMLQRFWZOBN-LAUBAEHRSA-N
Canonical SMILES	CCCCCCCCCCCCCCCC(=O)OCC(C1C(=C(C(=O)O1)O)O)O
Isomeric SMILES	CCCCCCCCCCCCCCCC(=O)OC[C@@H]([C@@H]1C(=C(C(=O)O1)O)O)O
WGK Germany	1
PubChem CID	54680660
Molecular Weight	414.53
Beilstein	96552

Certificates

Certificate of Analysis(COA)

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15 results found

Lot Number	Certificate Type	Date	Item
C2329628	Certificate of Analysis	Mar 08, 2023	A104525
C2329629	Certificate of Analysis	Mar 08, 2023	A104525
C2329630	Certificate of Analysis	Mar 08, 2023	A104525
D2319320	Certificate of Analysis	Mar 08, 2023	A104525
D2319321	Certificate of Analysis	Mar 08, 2023	A104525
D2319324	Certificate of Analysis	Mar 08, 2023	A104525
D2319352	Certificate of Analysis	Mar 08, 2023	A104525
D2319353	Certificate of Analysis	Mar 08, 2023	A104525
B2310301	Certificate of Analysis	Feb 16, 2023	A104525
B2310302	Certificate of Analysis	Feb 16, 2023	A104525
B2219232	Certificate of Analysis	Jan 21, 2022	A104525
B2219248	Certificate of Analysis	Jan 21, 2022	A104525
B2219323	Certificate of Analysis	Jan 21, 2022	A104525
B2221371	Certificate of Analysis	Jan 21, 2022	A104525
E2310735	Certificate of Analysis	Jan 21, 2022	A104525

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Chemical and Physical Properties

Solubility	Slightly soluble in ethyl alcohol.
Sensitivity	Light sensitive.
Specific Rotation[α]	22.5 ° (C=1, EtOH)
Melt Point(°C)	114°C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H319:Causes serious eye irritation H412:Harmful to aquatic life with long lasting effects
Precautionary Statements	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P501:Dispose of contents/container to ... P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help.
WGK Germany	1

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Ziwei Wang, Fujun Liu, Ying Luo, Xiangbo Zeng, Xuechen Pei, Guanhua Zhao, Min Zhang, Dayong Zhou, Fawen Yin. (2022) Effects of Tea Polyphenol and Its Combination with Other Antioxidants Added during the Extraction Process on Oxidative Stability of Antarctic Krill (Euphausia superba) Oil. Foods, 11 (23): (3768). [PMID:36496576] [10.3390/foods11233768]
2. Yuling Li, Xiaotong Wu, Zixuan Wu, Mingmin Zhong, Xiaoping Su, Youai Ye, Yan Liu, Lei Tan, Yong Liang. (2022) Colorimetric sensor array based on CoOOH nanoflakes for rapid discrimination of antioxidants in food. Analytical Methods, 14 (28): (2754-2760). [PMID:35781305] [10.1039/D2AY00692H]
3. Sun Dongdong, Wang Zekun, Zhang Pu, Yin Chenyang, Wang Jingyuan, Sun Yu, Chen Ying, Wang Weiyun, Sun Baoliang, Fan Cundong. (2021) Ruthenium-loaded mesoporous silica as tumor microenvironment-response nano-fenton reactors for precise cancer therapy. JOURNAL OF NANOBIOTECHNOLOGY, 19 (1): (1-16). [PMID:33827604] [10.1186/s12951-021-00848-x]
4. Shujie Wang, Guoqin Liu, Weiwei Cheng. (2021) Comparative evaluation of four free radical scavengers for the inhibition of individual glycidyl ester formation in rice bran oil determined by UPLC-MS/MS. INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 56 (6): (2983-2991). [PMID:] [10.1111/ijfs.14941]
5. Junhua Li, Yimei Shen, Jiali Zhai, Yujie Su, Luping Gu, Cuihua Chang, Yanjun Yang. (2021) Enhancing the oxidative stability of algal oil powders stabilized by egg yolk granules/lecithin composites. FOOD CHEMISTRY, 345 (128782). [PMID:33302099] [10.1016/j.foodchem.2020.128782]
6. Chang Li,Hanbing Jia,Mingyue Shen,Yuting Wang,Shaoping Nie,Yi Chen,Yongqiang Zhou,Yuanxing Wang,Mingyong Xie. (2015-10-20) Antioxidants Inhibit Formation of 3-Monochloropropane-1,2-diol Esters in Model Reactions.. Journal of agricultural and food chemistry, 63 ((44)): (9850-9854). [PMID:26478126]

References

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2. Gopa Mitra,P K Mukhopadhyay,S Ayyappan. (2008-03-11) Modulation of digestive enzyme activities during ontogeny of Labeo rohita larvae fed ascorbic acid enriched zooplankton.. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 149 ((4)): (341-350). [PMID:18329933]
3. Michelle Olsher,Parkson Lee-Gau Chong. (2008-08-13) Sterol superlattice affects antioxidant potency and can be used to assess adverse effects of antioxidants.. Analytical biochemistry, 382 ((1)): (1-8). [PMID:18694720]
4. J H Han,H-M Hwang,S Min,J M Krochta. (2008-11-21) Coating of peanuts with edible whey protein film containing alpha-tocopherol and ascorbyl palmitate.. Journal of food science, 73 ((8)): (E349-E355). [PMID:19019105]
5. Kyung Mi Lee,Jung Yeon Kwon,Ki Won Lee,Hyong Joo Lee. (2008-11-26) Ascorbic acid 6-palmitate suppresses gap-junctional intercellular communication through phosphorylation of connexin 43 via activation of the MEK-ERK pathway.. Mutation research, 660 ((1-2)): (51-56). [PMID:19026667]
6. Yohko Kuge,Ayato Kanda,Setsuko Hara. (2009-05-12) Pursuit of oxidation behavior for conjugated polyenoyl glycerols and establishment of their novel oxidation prevention method.. Journal of oleo science, 58 ((6)): (295-301). [PMID:19430191]
7. M M Almeida,J M P Alves,D C S Patto,C R R C Lima,J S Quenca-Guillen,M I R M Santoro,E R M Kedor-Hackmann. (2009-05-27) Determination of tocopheryl acetate and ascorbyl tetraisopalmitate in cosmetic formulations by HPLC.. International journal of cosmetic science, 31 ((6)): (445-450). [PMID:19467029]
8. Mayura Wittayasuporn,Sirirat Rengpipat,Tanapat Palaga,Pravit Asawanonda,Nattaporn Anumansirikul,Supasorn P Wanichwecharungruang. (2009-07-02) Chitosan derivative nanocarrier: safety evaluation,antibacterial property and ascorbyl palmitate encapsulation.. Journal of microencapsulation, 27 ((3)): (218-225). [PMID:19566395]
9. Charlotte Jacobsen. (2010-04-15) Enrichment of foods with omega-3 fatty acids: a multidisciplinary challenge.. Annals of the New York Academy of Sciences, 1190 (141-150). [PMID:20388145]
10. P O Nnamani,A A Attama,E C Ibezim,M U Adikwu. (2010-06-18) SRMS142-based solid lipid microparticles: application in oral delivery of glibenclamide to diabetic rats.. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 76 ((1)): (68-74). [PMID:20554020]
11. Raju Jukanti,Gopinath Devraj,Apte S Shashank,Rambhau Devraj. (2011-01-27) Biodistribution of ascorbyl palmitate loaded doxorubicin pegylated liposomes in solid tumor bearing mice.. Journal of microencapsulation, 28 ((2)): (142-149). [PMID:21265713]
12. Lindomar A Lerin,Miriam C Feiten,Aline Richetti,Geciane Toniazzo,Helen Treichel,Marcio A Mazutti,J Vladimir Oliveira,Enrique G Oestreicher,Débora de Oliveira. (2011-01-29) Enzymatic synthesis of ascorbyl palmitate in ultrasound-assisted system: process optimization and kinetic evaluation.. Ultrasonics sonochemistry, 18 ((5)): (988-996). [PMID:21273112]
13. Dilyana Paneva,Nevena Manolova,Mariana Argirova,Iliya Rashkov. (2011-07-06) Antibacterial electrospun poly(ɛ-caprolactone)/ascorbyl palmitate nanofibrous materials.. International journal of pharmaceutics, 416 ((1)): (346-355). [PMID:21726615]
14. Luciano Benedini,Maria Laura Fanani,Bruno Maggio,Natalia Wilke,Paula Messina,Santiago Palma,Pablo Schulz. (2011-07-20) Surface phase behavior and domain topography of ascorbyl palmitate monolayers.. Langmuir : the ACS journal of surfaces and colloids, 27 ((17)): (10914-10919). [PMID:21766856]
15. Stephan Braun,Alexander Botzki,Sunnhild Salmen,Christian Textor,Günther Bernhardt,Stefan Dove,Armin Buschauer. (2011-08-02) Design of benzimidazole- and benzoxazole-2-thione derivatives as inhibitors of bacterial hyaluronan lyase.. European journal of medicinal chemistry, 46 ((9)): (4419-4429). [PMID:21803461]
16. Rupa R Sawant,Onkar S Vaze,Tao Wang', "Gerard G M D'Souza", 'Karen Rockwell,Keyur Gada,Ban-An Khaw,Vladimir P Torchilin. (2011-08-17) Palmitoyl ascorbate liposomes and free ascorbic acid: comparison of anticancer therapeutic effects upon parenteral administration.. Pharmaceutical research, 29 ((2)): (375-383). [PMID:21845505]
17. DeMarquis O Loyd,Sean M Lynch. (2011-08-30) Lipid-soluble vitamin C palmitate and protection of human high-density lipoprotein from hypochlorite-mediated oxidation.. International journal of cardiology, 152 ((2)): (256-257). [PMID:21872949]
18. Bente M Jensen,John Sørensen,Grith Mortensen,Martin B Sørensen,Trine K Dalsgaard. (2011-11-11) Effect of antioxidants on oxidation during the production of whey fat concentrate.. Journal of agricultural and food chemistry, 59 ((24)): (13012-13017). [PMID:22070410]
19. A Carmichael. (2012-04-28) PA and fish oil.. British dental journal, 212 ((8)): (356-357). [PMID:22538879]
20. L Capretto,S Mazzitelli,G Colombo,R Piva,L Penolazzi,R Vecchiatini,X Zhang,C Nastruzzi. (2012-08-14) Production of polymeric micelles by microfluidic technology for combined drug delivery: application to osteogenic differentiation of human periodontal ligament mesenchymal stem cells (hPDLSCs).. International journal of pharmaceutics, 440 ((2)): (195-206). [PMID:22884778]
21. Mi Kyung Kim,Ji-Soo Lee,Kwang Yup Kim,Hyeon Gyu Lee. (2012-12-19) Ascorbyl palmitate-loaded chitosan nanoparticles: characteristic and polyphenol oxidase inhibitory activity.. Colloids and surfaces. B, Biointerfaces, 103 (391-394). [PMID:23247266]
22. Mirjam Gosenca,Marija Bešter-Rogač,Mirjana Gašperlin. (2013-05-07) Lecithin based lamellar liquid crystals as a physiologically acceptable dermal delivery system for ascorbyl palmitate.. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 50 ((1)): (114-122). [PMID:23643736]
23. Li Xiao,Takeki Tsutsui,Nobuhiko Miwa. (2014-06-06) The lipophilic vitamin C derivative, 6-o-palmitoylascorbate, protects human lymphocytes, preferentially over ascorbate, against X-ray-induced DNA damage, lipid peroxidation, and protein carbonylation.. Molecular and cellular biochemistry, 394 ((1-2)): (247-259). [PMID:24898782]
24. Lingyan Kong,Gregory R Ziegler. (2014-07-20) Molecular encapsulation of ascorbyl palmitate in preformed V-type starch and amylose.. Carbohydrate polymers, 111 (256-263). [PMID:25037350]
25. Marija Stojanović,Milica Carević,Mladen Mihailović,Dušan Veličković,Aleksandra Dimitrijević,Nenad Milosavić,Dejan Bezbradica. (2014-09-17) Influence of fatty acid on lipase-catalyzed synthesis of ascorbyl esters and their free radical scavenging capacity.. Biotechnology and applied biochemistry, 62 ((4)): (458-466). [PMID:25224149]
26. Mostafa Nakach,Jean-René Authelin,Tharwat Tadros,Laurence Galet,Alain Chamayou. (2014-10-04) Engineering of nano-crystalline drug suspensions: employing a physico-chemistry based stabilizer selection methodology or approach.. International journal of pharmaceutics, 476 ((1-2)): (277-288). [PMID:25278040]
27. Atikorn Panya,Waranya Temthawee,Natthaporn Phonsatta,Danai Charoensuk,Pawinee Deetae,Wonnop Visessanguan,Eric A Decker. (2015-08-15) Apolar Radical Initiated Conjugated Autoxidizable Triene (ApoCAT) Assay: Effects of Oxidant Locations on Antioxidant Capacities and Interactions.. Journal of agricultural and food chemistry, 63 ((34)): (7546-7555). [PMID:26273904]
28. Chen-Yuan Hsiao,Tien-Hua Chen,Tzu-Hui Chu,Yen-Nien Ting,Pei-Jiun Tsai,Jia-Fwu Shyu. (2020-10-06) Calcitonin Induces Bone Formation by Increasing Expression of Wnt10b in Osteoclasts in Ovariectomy-Induced Osteoporotic Rats.. Frontiers in endocrinology, 11 (613-613). [PMID:33013696]
29. Martin Spickenreither,Stephan Braun,Günther Bernhardt,Stefan Dove,Armin Buschauer. (2006-08-16) Novel 6-O-acylated vitamin C derivatives as hyaluronidase inhibitors with selectivity for bacterial lyases.. Bioorganic & medicinal chemistry letters, 16 ((20)): (5313-5316). [PMID:16908142]
30. Rangrong Yoksan,Jatesuda Jirawutthiwongchai,Kridsada Arpo. (2009-12-17) Encapsulation of ascorbyl palmitate in chitosan nanoparticles by oil-in-water emulsion and ionic gelation processes.. Colloids and surfaces. B, Biointerfaces, 76 ((1)): (292-297). [PMID:20004558]
31. Mirjam Gosenca,Aleš Obreza,Slavko Pečar,Mirjana Gašperlin. (2010-09-17) A new approach for increasing ascorbyl palmitate stability by addition of non-irritant co-antioxidant.. AAPS PharmSciTech, 11 ((3)): (1485-1492). [PMID:20845090]
32. Luciano Benedini,Paula V Messina,Santiago D Palma,Daniel A Allemandi,Pablo C Schulz. (2011-10-15) The ascorbyl palmitate-polyethyleneglycol 400-water system phase behavior.. Colloids and surfaces. B, Biointerfaces, 89 (265-270). [PMID:21996464]
33. Feng-Jen Tsai,Yuan-Dai Wang,Cheng-Chi Chen,Chen Hsieh,Zhi-Jiao Cheng,Yu-Jen Wu. (2012-04-28) Evaluation of the antioxidative capability of commonly used antioxidants in dermocosmetics by in vivo detection of protein carbonylation in human stratum corneum.. Journal of photochemistry and photobiology. B, Biology, 112 (7-15). [PMID:22537778]
34. Milagro Mottola,Natalia Wilke,Luciano Benedini,Rafael Gustavo Oliveira,Maria Laura Fanani. (2013-06-29) Ascorbyl palmitate interaction with phospholipid monolayers: electrostatic and rheological preponderancy.. Biochimica et biophysica acta, 1828 ((11)): (2496-2505). [PMID:23806650]
35. Alex C M Oliveira,Matthew R Miller. (2014-05-27) Purification of Alaskan walleye pollock (Gadus chalcogrammus) and New Zealand hoki (Macruronus novaezelandiae) liver oil using short path distillation.. Nutrients, 6 ((5)): (2059-2076). [PMID:24858408]
36. Ziwei Wang, Fujun Liu, Ying Luo, Xiangbo Zeng, Xuechen Pei, Guanhua Zhao, Min Zhang, Dayong Zhou, Fawen Yin. (2022) Effects of Tea Polyphenol and Its Combination with Other Antioxidants Added during the Extraction Process on Oxidative Stability of Antarctic Krill (Euphausia superba) Oil. Foods, 11 (23): (3768). [PMID:36496576] [10.3390/foods11233768]
37. Yuling Li, Xiaotong Wu, Zixuan Wu, Mingmin Zhong, Xiaoping Su, Youai Ye, Yan Liu, Lei Tan, Yong Liang. (2022) Colorimetric sensor array based on CoOOH nanoflakes for rapid discrimination of antioxidants in food. Analytical Methods, 14 (28): (2754-2760). [PMID:35781305] [10.1039/D2AY00692H]
38. Sun Dongdong, Wang Zekun, Zhang Pu, Yin Chenyang, Wang Jingyuan, Sun Yu, Chen Ying, Wang Weiyun, Sun Baoliang, Fan Cundong. (2021) Ruthenium-loaded mesoporous silica as tumor microenvironment-response nano-fenton reactors for precise cancer therapy. JOURNAL OF NANOBIOTECHNOLOGY, 19 (1): (1-16). [PMID:33827604] [10.1186/s12951-021-00848-x]
39. Shujie Wang, Guoqin Liu, Weiwei Cheng. (2021) Comparative evaluation of four free radical scavengers for the inhibition of individual glycidyl ester formation in rice bran oil determined by UPLC-MS/MS. INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 56 (6): (2983-2991). [PMID:] [10.1111/ijfs.14941]
40. Junhua Li, Yimei Shen, Jiali Zhai, Yujie Su, Luping Gu, Cuihua Chang, Yanjun Yang. (2021) Enhancing the oxidative stability of algal oil powders stabilized by egg yolk granules/lecithin composites. FOOD CHEMISTRY, 345 (128782). [PMID:33302099] [10.1016/j.foodchem.2020.128782]
41. Chang Li,Hanbing Jia,Mingyue Shen,Yuting Wang,Shaoping Nie,Yi Chen,Yongqiang Zhou,Yuanxing Wang,Mingyong Xie. (2015-10-20) Antioxidants Inhibit Formation of 3-Monochloropropane-1,2-diol Esters in Model Reactions.. Journal of agricultural and food chemistry, 63 ((44)): (9850-9854). [PMID:26478126]

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L-Ascorbic acid 6-palmitate - USP grade, high purity , CAS No.137-66-6

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Show more⌵

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Citations of This Product

References

Solution Calculators

Molarity Calculator

Dilution Calculator

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