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L-Aspartic acid - 98%, high purity , CAS No.56-84-8, Agonist of GluN1;Agonist of GluN2A;Agonist of GluN2B;Agonist of GluN2C;Agonist of GluN2D

  • Moligand™
  • ≥98%
Item Number
A137730
Grouped product items
SKUSizeAvailabilityPrice Qty
A137730-100g
100g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$11.90
A137730-500g
500g
In stock
$45.90

Basic Description

SynonymsL-aspartic acid|aspartic acid|56-84-8|H-Asp-OH|Asparagic acid|(2S)-2-aminobutanedioic acid|L-aspartate|aspartate|Aspatofort|(S)-2-Aminosuccinic acid|L-Aminosuccinic acid|L-Asparagic acid|Asparaginic acid|L-Asparaginic acid|(S)-Aspartic acid|(2S)-Aspartic
Specifications & PurityMoligand™, ≥98%
Shipped InNormal
GradeMoligand™
Action TypeAGONIST
Mechanism of actionAgonist of GluN1;Agonist of GluN2A;Agonist of GluN2B;Agonist of GluN2C;Agonist of GluN2D

Associated Targets

CTDNEP1 Tbio CTD nuclear envelope phosphatase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP1A2 Tchem Cytochrome P450 1A2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP2D6 Tclin Cytochrome P450 2D6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP2C19 Tchem Cytochrome P450 2C19 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

DRD1 Tclin D(1A) dopamine receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ESR1 Tclin Estrogen receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GABRA1 Tclin Gamma-aminobutyric acid receptor subunit alpha-1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP2C9 Tchem Cytochrome P450 2C9 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HRH3 Tclin Histamine H3 receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLC6A2 Tclin Sodium-dependent noradrenaline transporter 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLC6A3 Tclin Sodium-dependent dopamine transporter 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLC6A4 Tclin Sodium-dependent serotonin transporter 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PGR Tclin Progesterone receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PDE3A Tclin cGMP-inhibited 3',5'-cyclic phosphodiesterase A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PTGS1 Tclin Prostaglandin G/H synthase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PDE4A Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CA1 Tclin Carbonic anhydrase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CA2 Tclin Carbonic anhydrase 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CA4 Tclin Carbonic anhydrase 4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

DRD3 Tclin D(3) dopamine receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KDR Tclin Vascular endothelial growth factor receptor 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CHRM2 Tclin Muscarinic acetylcholine receptor M2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ACE Tclin Angiotensin-converting enzyme 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ACHE Tclin Acetylcholinesterase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CHRM1 Tclin Muscarinic acetylcholine receptor M1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ADRA2A Tclin Alpha-2A adrenergic receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ADRA1A Tclin Alpha-1A adrenergic receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

AR Tclin Androgen receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MAOA Tclin Amine oxidase [flavin-containing] A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ALDH1A1 Tchem Retinal dehydrogenase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HTR1A Tclin 5-hydroxytryptamine receptor 1A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ADORA3 Tchem Adenosine receptor A3 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HTR2B Tclin 5-hydroxytryptamine receptor 2B 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TBXA2R Tclin Thromboxane A2 receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

F2 Tclin Prothrombin 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GRM1 Tchem Metabotropic glutamate receptor 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GRM2 Tchem Metabotropic glutamate receptor 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GRM6 Tchem Metabotropic glutamate receptor 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

OPRM1 Tclin Mu-type opioid receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GRIN1 Tclin Glutamate receptor ionotropic, NMDA 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GRIN2C Tclin Glutamate receptor ionotropic, NMDA 2C 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name (2S)-2-aminobutanedioic acid
INCHI InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m0/s1
InChi Key CKLJMWTZIZZHCS-REOHCLBHSA-N
Canonical SMILES N[C@@H](CC(O)=O)C(O)=O
Isomeric SMILES C([C@@H](C(=O)O)N)C(=O)O
WGK Germany 1
RTECS CI9098500
PubChem CID 5960
Molecular Weight 133.10
Beilstein 1723530
Reaxy-Rn 1723530

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

8 results found

Lot NumberCertificate TypeDateItem
G2405100Certificate of AnalysisJul 13, 2024 A137730
G2405101Certificate of AnalysisJul 12, 2024 A137730
C2210051Certificate of AnalysisMay 22, 2023 A137730
H2213042Certificate of AnalysisAug 26, 2022 A137730
B2420078Certificate of AnalysisAug 20, 2022 A137730
G2303577Certificate of AnalysisAug 20, 2022 A137730
H2213011Certificate of AnalysisAug 20, 2022 A137730
H2401016Certificate of AnalysisAug 20, 2022 A137730

Chemical and Physical Properties

SolubilityH2O 5 mg/mL; 0.5 M HCl 50 mg/mL (with heat); 1 M NaOH 50 mg/mL
Melt Point(°C)270-271°C

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

H302:Harmful if swallowed

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

WGK Germany 1
RTECS CI9098500
Reaxy-Rn 1723530
Merck Index 840

Related Documents

References

1. Boudker O, Ryan RM, Yernool D, Shimamoto K, Gouaux E.  (2007)  Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter..  Nature,  445  (7126): (387-93).  [PMID:17230192]
2. C Härnryd,L Bjerkenstedt,V E Grimm,G Sedvall.  (1979-08-08)  Reduction of MOPEG levels in cerebrospinal fluid of psychotic women after electroconvulsive treatment..  Psychopharmacology,  64  ((2)): (131-134).  [PMID:115032]
3. A K Batta,R Arora,G Salen,G S Tint,D Eskreis,S Katz.  (1989-12-01)  Characterization of serum and urinary bile acids in patients with primary biliary cirrhosis by gas-liquid chromatography-mass spectrometry: effect of ursodeoxycholic acid treatment..  Journal of lipid research,  30  ((12)): (1953-1962).  [PMID:2621422]
4. J Szebeni,C Eskelson,R Sampliner,B Hartmann,J Griffin,T Dormandy,R R Watson.  (1986-12-01)  Plasma fatty acid pattern including diene-conjugated linoleic acid in ethanol users and patients with ethanol-related liver disease..  Alcoholism, clinical and experimental research,  10  ((6)): (647-650).  [PMID:3101533]
5. D Rating,H Siemes,W Löscher.  (1983-01-01)  Low CSF GABA concentration in children with febrile convulsions, untreated epilepsy, and meningitis..  Journal of neurology,  230  ((4)): (217-225).  [PMID:6198481]
6. C J McClain,L Zieve,W M Doizaki,S Gilberstadt,G R Onstad.  (1980-04-01)  Blood methanethiol in alcoholic liver disease with and without hepatic encephalopathy..  Gut,  21  ((4)): (318-323).  [PMID:7429293]
7. D Machover.  (1994-12-01)  The pharmacologic modulation of 5-fluorouracil with folinic acid, methotrexate, trimetrexate, and n-phosphonacetyl-l-aspartic acid (PALA). Mechanisms of the interactions and clinical data..  Bulletin du cancer,  81 Suppl 2  (74s-77s).  [PMID:7727863]
8. P Burman,J Hetta,L Wide,J E Månsson,R Ekman,F A Karlsson.  (1996-03-01)  Growth hormone treatment affects brain neurotransmitters and thyroxine [see comment]..  Clinical endocrinology,  44  ((3)): (319-324).  [PMID:8729530]
9. E R Waite,M J Collins,S Ritz-Timme,H W Schutz,C Cattaneo,H I Borrman.  (1999-09-11)  A review of the methodological aspects of aspartic acid racemization analysis for use in forensic science..  Forensic science international,  103  ((2)): (113-124).  [PMID:10481264]
10. G Halperin,M Elisaf,E Leitersdorf,D Harats.  (2000-07-20)  A new method for determination of serum cholestanol by high-performance liquid chromatography with ultraviolet detection..  Journal of chromatography. B, Biomedical sciences and applications,  742  ((2)): (345-352).  [PMID:10901139]
11. Stefanie Ritz-Timme,Matthew J Collins.  (2002-06-01)  Racemization of aspartic acid in human proteins..  Ageing research reviews,  ((1)): (43-59).  [PMID:12039448]
12. C J L Silwood,E Lynch,A W D Claxson,M C Grootveld.  (2002-07-05)  1H and (13)C NMR spectroscopic analysis of human saliva..  Journal of dental research,  81  ((6)): (422-427).  [PMID:12097436]
13. Roger F Butterworth.  (2003-02-27)  Pathophysiology of hepatic encephalopathy: a new look at ammonia..  Metabolic brain disease,  17  ((4)): (221-227).  [PMID:12602499]
14. Carl H Rose,Brad D Thigpen,James A Bofill,Julie Cushman,Warren L May,James N Martin.  (2004-11-02)  Obstetric implications of antepartum corticosteroid therapy for HELLP syndrome..  Obstetrics and gynecology,  104  ((5 Pt 1)): (1011-1014).  [PMID:15516393]
15. Prasanna M Bhende,William T Seaman,Henri-Jacques Delecluse,Shannon C Kenney.  (2005-05-28)  BZLF1 activation of the methylated form of the BRLF1 immediate-early promoter is regulated by BZLF1 residue 186..  Journal of virology,  79  ((12)): (7338-7348).  [PMID:15919888]
16. Baohai Shao,Abderrazzaq Belaaouaj,Christophe L M J Verlinde,Xiaoyun Fu,Jay W Heinecke.  (2005-06-22)  Methionine sulfoxide and proteolytic cleavage contribute to the inactivation of cathepsin G by hypochlorous acid: an oxidative mechanism for regulation of serine proteinases by myeloperoxidase..  The Journal of biological chemistry,  280  ((32)): (29311-29321).  [PMID:15967795]
17. Mark G Jones,Elizabeth Cooper,Saira Amjad,C Stewart Goodwin,Jeffrey L Barron,Ronald A Chalmers.  (2005-07-05)  Urinary and plasma organic acids and amino acids in chronic fatigue syndrome..  Clinica chimica acta; international journal of clinical chemistry,  361  ((1-2)): (150-158).  [PMID:15992788]
18. Susumu Ohtani,Toshiharu Yamamoto.  (2005-10-18)  Strategy for the estimation of chronological age using the aspartic acid racemization method with special reference to coefficient of correlation between D/L ratios and ages..  Journal of forensic sciences,  50  ((5)): (1020-1027).  [PMID:16225206]
19. Ken H Darzy,Robert D Murray,Helena K Gleeson,Suzan S Pezzoli,Michael O Thorner,Stephen M Shalet.  (2005-12-31)  The impact of short-term fasting on the dynamics of 24-hour growth hormone (GH) secretion in patients with severe radiation-induced GH deficiency..  The Journal of clinical endocrinology and metabolism,  91  ((3)): (987-994).  [PMID:16384844]
20. R A Azevedo,M Lancien,P J Lea.  (2006-03-10)  The aspartic acid metabolic pathway, an exciting and essential pathway in plants..  Amino acids,  30  ((2)): (143-162).  [PMID:16525757]
21. Phedias Diamandis,Jan Wildenhain,Ian D Clarke,Adrian G Sacher,Jeremy Graham,David S Bellows,Erick K M Ling,Ryan J Ward,Leanne G Jamieson,Mike Tyers,Peter B Dirks.  (2007-04-10)  Chemical genetics reveals a complex functional ground state of neural stem cells..  Nature chemical biology,  ((5)): (268-273).  [PMID:17417631]
22. Bram Baert,Eric Deconinck,Mireille Van Gele,Marian Slodicka,Paul Stoppie,Samuel Bodé,Guido Slegers,Yvan Vander Heyden,Jo Lambert,Johan Beetens,Bart De Spiegeleer.  (2007-09-11)  Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds..  Bioorganic & medicinal chemistry,  15  ((22)): (6943-6955).  [PMID:17827020]
23. David S Wishart,Michael J Lewis,Joshua A Morrissey,Mitchel D Flegel,Kevin Jeroncic,Yeping Xiong,Dean Cheng,Roman Eisner,Bijaya Gautam,Dan Tzur,Summit Sawhney,Fiona Bamforth,Russ Greiner,Liang Li.  (2008-05-27)  The human cerebrospinal fluid metabolome..  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences,  871  ((2)): (164-173).  [PMID:18502700]
24. Vladimir N Noskov,Nicholas Co Lee,Vladimir Larionov,Natalay Kouprina.  (2011-10-11)  Rapid generation of long tandem DNA repeat arrays by homologous recombination in yeast to study their function in mammalian genomes..  Biological procedures online,  13  ((1)): (8-8).  [PMID:21982381]
25. Przemyslaw Swiatkowski,Federico Sesti.  (2013-03-21)  Delayed pharyngeal repolarization promotes abnormal calcium buildup in aging muscle..  Biochemical and biophysical research communications,  433  ((3)): (354-357).  [PMID:23510998]
26. I M Mykheĭtseva.  (2013-05-30)  [Protective action of melatonin in experimental glaucoma in rats]..  Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994),  59  ((1)): (78-83).  [PMID:23713353]
27. T M Kuvaeva,Zh I Katashkina,A D Kivero,S V Smirnov.  (2013-06-26)  [Novel NADPH-dependent L-aspartate dehydrogenases from the mesophilic nitrogen-fixing bacteria Rhodopseudomonas palustris and Bradyrhizobium japonicum]..  Prikladnaia biokhimiia i mikrobiologiia,  49  ((2)): (155-163).  [PMID:23795474]
28. F Granata,G Pandolfo,S Vinci,C Alafaci,N Settineri,R Morabito,A Pitrone,M Longo.  (2013-07-19)  Proton magnetic resonance spectroscopy (H-MRS) in chronic schizophrenia. A single-voxel study in three regions involved in a pathogenetic theory..  The neuroradiology journal,  26  ((3)): (277-283).  [PMID:23859282]
29. Antonio C Ruzzini,Shiva Bhowmik,Subhangi Ghosh,Katherine C Yam,Jeffrey T Bolin,Lindsay D Eltis.  (2013-09-27)  A substrate-assisted mechanism of nucleophile activation in a Ser-His-Asp containing C-C bond hydrolase..  Biochemistry,  52  ((42)): (7428-7438).  [PMID:24067021]
30. Zhongli Yang,Chen Lin,Shaolin Wang,Chamindi Seneviratne,Jundong Wang,Ming D Li.  (2013-10-01)  Determination of allelic expression of SNP rs1880676 in choline acetyltransferase gene in HeLa cells..  Neuroscience letters,  555  (215-219).  [PMID:24076142]
31. Baruch I Kanner.  (2013-10-08)  Substrate-induced rearrangements in glutamate-transporter homologs..  Nature structural & molecular biology,  20  ((10)): (1142-1144).  [PMID:24096399]
32. Thanate Juntadech,Yodsoi Kanintronkul,Chalermpol Kanchanawarin,Gerd Katzenmeier,Chanan Angsuthanasombat.  (2013-10-15)  Importance of polarity of the α4-α5 loop residue-Asn(166) in the pore-forming domain of the Bacillus thuringiensis Cry4Ba toxin: implications for ion permeation and pore opening..  Biochimica et biophysica acta,  1838  ((1 Pt B)): (319-327).  [PMID:24120447]
33. Christopher Mulligan,Joseph A Mindell.  (2013-10-25)  Mechanism of transport modulation by an extracellular loop in an archaeal excitatory amino acid transporter (EAAT) homolog..  The Journal of biological chemistry,  288  ((49)): (35266-35276).  [PMID:24155238]
34. Jennifer L Kellie,Katie A Wilson,Stacey D Wetmore.  (2013-10-31)  Standard role for a conserved aspartate or more direct involvement in deglycosylation? An ONIOM and MD investigation of adenine-DNA glycosylase..  Biochemistry,  52  ((48)): (8753-8765).  [PMID:24168684]
35. S K Goergen,H Ang,F Wong,E A Carse,M Charlton,R Evans,G Whiteley,J Clark,D Shipp,D Jolley,E Paul,J L Y Cheong.  (2013-11-12)  Early MRI in term infants with perinatal hypoxic-ischaemic brain injury: interobserver agreement and MRI predictors of outcome at 2 years..  Clinical radiology,  69  ((1)): (72-81).  [PMID:24210250]
36. Xin Yang,Margaret A Hamner,Angus M Brown,Richard D Evans,Zu-Cheng Ye,Shengdi Chen,Bruce R Ransom.  (2013-11-19)  Novel hypoglycemic injury mechanism: N-methyl-D-aspartate receptor-mediated white matter damage..  Annals of neurology,  75  ((4)): (492-507).  [PMID:24242287]
37. Chih-Ping Yang,Chen-Hwan Cherng,Ching-Tang Wu,Hui-Yi Huang,Pao-Luh Tao,Sing-Ong Lee,Chih-Shung Wong.  (2013-11-22)  Intrathecal ultra-low dose naloxone enhances the antihyperalgesic effects of morphine and attenuates tumor necrosis factor-α and tumor necrosis factor-α receptor 1 expression in the dorsal horn of rats with partial sciatic nerve transection..  Anesthesia and analgesia,  117  ((6)): (1493-1502).  [PMID:24257399]
38. Xiaoyang Guan,Matthew R Drake,Zhongping Tan.  (2013-11-26)  Total synthesis of human galanin-like peptide through an aspartic acid ligation..  Organic letters,  15  ((24)): (6128-6131).  [PMID:24266801]
39. Jenna Friedt,Fern M V Leavens,Evan Mercier,Hans-Joachim Wieden,Ute Kothe.  (2013-12-29)  An arginine-aspartate network in the active site of bacterial TruB is critical for catalyzing pseudouridine formation..  Nucleic acids research,  42  ((6)): (3857-3870).  [PMID:24371284]
40. Toshihiko Sugiki,Naoko Utsunomiya-Tate.  (2014-01-03)  Site-specific aspartic acid isomerization regulates self-assembly and neurotoxicity of amyloid-β..  Biochemical and biophysical research communications,  441  ((2)): (493-498).  [PMID:24383085]
41. Dong-Kee Kim,Shi-Nae Park,Kyoung-Ho Park,Chan Woo Park,Keum-Jin Yang,Jong-Duk Kim,Min-Sik Kim.  (2014-01-23)  Development of a drug delivery system for the inner ear using poly(amino acid)-based nanoparticles..  Drug delivery,  22  ((3)): (367-374).  [PMID:24447111]
42. T Kajikawa,S Yamada,T Tauchi,T Awata,S Yamaba,C Fujihara,S Murakami.  (2014-01-24)  Inhibitory effects of PLAP-1/asporin on periodontal ligament cells..  Journal of dental research,  93  ((4)): (400-405).  [PMID:24453179]
43. Giles S Kendall,Andrew Melbourne,Samantha Johnson,David Price,Alan Bainbridge,Roxanna Gunny,Angela Huertas-Ceballos,Ernest B Cady,Sebastian Ourselin,Neil Marlow,Nicola J Robertson.  (2014-01-31)  White matter NAA/Cho and Cho/Cr ratios at MR spectroscopy are predictive of motor outcome in preterm infants..  Radiology,  271  ((1)): (230-238).  [PMID:24475798]
44. Velia Minicozzi,Roberta Chiaraluce,Valerio Consalvi,Cesare Giordano,Claudia Narcisi,Pasqualina Punzi,Giancarlo C Rossi,Silvia Morante.  (2014-03-04)  Computational and experimental studies on β-sheet breakers targeting Aβ1-40 fibrils..  The Journal of biological chemistry,  289  ((16)): (11242-11252).  [PMID:24584938]
45. Michaela M Kraus,Helmut Prast,Athineos Philippu.  (2014-03-13)  Influence of parafascicular thalamic input on neuronal activity within the nucleus accumbens is mediated by nitric oxide - an in vivo study..  Life sciences,  102  ((1)): (49-54).  [PMID:24607782]
46. Breanne P Cuddington,Karen L Mossman.  (2014-04-04)  Permissiveness of human cancer cells to oncolytic bovine herpesvirus 1 is mediated in part by KRAS activity..  Journal of virology,  88  ((12)): (6885-6895).  [PMID:24696490]
47. Qin Wu,Zengqiang Gao,Yong Wei,Guolin Ma,Yuchuan Zheng,Yuhui Dong,Yangzhong Liu.  (2014-04-25)  Conserved residues that modulate protein trans-splicing of Npu DnaE split intein..  The Biochemical journal,  461  ((2)): (247-255).  [PMID:24758175]
48. Jing-Li Gan,Zheng-Xiang Cheng,Hui-Feng Duan,Jia-Ming Yang,Xi-Quan Zhu,Cun-You Gao.  (2014-05-17)  Atypical antipsychotic drug treatment for 6 months restores N-acetylaspartate in left prefrontal cortex and left thalamus of first-episode patients with early onset schizophrenia: A magnetic resonance spectroscopy study..  Psychiatry research,  223  ((1)): (23-27).  [PMID:24831926]
49. Sara Llufriu,John Kornak,Helene Ratiney,Joonmi Oh,Don Brenneman,Bruce A Cree,Mehul Sampat,Stephen L Hauser,Sarah J Nelson,Daniel Pelletier.  (2014-05-21)  Magnetic resonance spectroscopy markers of disease progression in multiple sclerosis..  JAMA neurology,  71  ((7)): (840-847).  [PMID:24839987]
50. Edi Erwan,Vishwajit Sur Chowdhury,Mao Nagasawa,Ryosei Goda,Tsuyoshi Otsuka,Shinobu Yasuo,Mitsuhiro Furuse.  (2014-06-03)  Oral administration of D-aspartate, but not L-aspartate, depresses rectal temperature and alters plasma metabolites in chicks..  Life sciences,  109  ((1)): (65-71).  [PMID:24881518]
51. Yuanyuan Chen,Hong Tang,William Seibel,Ruben Papoian,Ki Oh,Xiaoyu Li,Jianye Zhang,Marcin Golczak,Krzysztof Palczewski,Philip D Kiser.  (2014-06-11)  Identification and characterization of novel inhibitors of Mammalian aspartyl aminopeptidase..  Molecular pharmacology,  86  ((2)): (231-242).  [PMID:24913940]
52. Wilson I Gonsalves,Michelle R Mahoney,Daniel J Sargent,Garth D Nelson,Steven R Alberts,Frank A Sinicrope,Richard M Goldberg,Paul J Limburg,Stephen N Thibodeau,Axel Grothey,Joleen M Hubbard,Emily Chan,Suresh Nair,Jeffrey L Berenberg,Robert R McWilliams.  (2014-06-14)  Patient and tumor characteristics and BRAF and KRAS mutations in colon cancer, NCCTG/Alliance N0147..  Journal of the National Cancer Institute,  106  ((7)): (doi:10-doi:10).  [PMID:24925349]
53. Helen N Saada,Ussama Z Said,Elsayed M E Mahdy,Hattem E Elmezayen,Shereen M Shedid.  (2014-06-18)  Fish oil omega-3 fatty acids reduce the severity of radiation-induced oxidative stress in the rat brain..  International journal of radiation biology,  90  ((12)): (1179-1183).  [PMID:24937371]
54. Marco Flores-Méndez,Diana Ramírez,Nely Alamillo,Luisa C Hernández-Kelly,Luz María Del Razo,Arturo Ortega.  (2014-06-24)  Fluoride exposure regulates the elongation phase of protein synthesis in cultured Bergmann glia cells..  Toxicology letters,  229  ((1)): (126-133).  [PMID:24954634]
55. Manuel Neeb,Paul Czodrowski,Andreas Heine,Luzi Jakob Barandun,Christoph Hohn,François Diederich,Gerhard Klebe.  (2014-06-24)  Chasing protons: how isothermal titration calorimetry, mutagenesis, and pKa calculations trace the locus of charge in ligand binding to a tRNA-binding enzyme..  Journal of medicinal chemistry,  57  ((13)): (5554-5565).  [PMID:24955548]
56. Rim Benali-Cherif,Radhwane Takouachet,El-Eulmi Bendeif,Nourredine Benali-Cherif.  (2014-07-06)  A comparative study of two polymorphs of L-aspartic acid hydrochloride..  Acta crystallographica. Section C, Structural chemistry,  70  ((Pt 7)): (689-692).  [PMID:24992112]
57. Yin-Chih Fu,Tzu-Fun Fu,Hung-Jen Wang,Che-Wei Lin,Gang-Hui Lee,Shun-Cheng Wu,Chih-Kuang Wang.  (2014-07-23)  Aspartic acid-based modified PLGA-PEG nanoparticles for bone targeting: in vitro and in vivo evaluation..  Acta biomaterialia,  10  ((11)): (4583-4596).  [PMID:25050775]
58. N Andres Parra,Andrew A Maudsley,Rakesh K Gupta,Fazilat Ishkanian,Kris Huang,Gail R Walker,Kyle Padgett,Bhaswati Roy,Joseph Panoff,Arnold Markoe,Radka Stoyanova.  (2014-07-30)  Volumetric spectroscopic imaging of glioblastoma multiforme radiation treatment volumes..  International journal of radiation oncology, biology, physics,  90  ((2)): (376-384).  [PMID:25066215]
59. Alexandra Deviers,Soléakhéna Ken,Thomas Filleron,Benjamin Rowland,Andrea Laruelo,Isabelle Catalaa,Vincent Lubrano,Pierre Celsis,Isabelle Berry,Giovanni Mogicato,Elizabeth Cohen-Jonathan Moyal,Anne Laprie.  (2014-08-12)  Evaluation of the lactate-to-N-acetyl-aspartate ratio defined with magnetic resonance spectroscopic imaging before radiation therapy as a new predictive marker of the site of relapse in patients with glioblastoma multiforme..  International journal of radiation oncology, biology, physics,  90  ((2)): (385-393).  [PMID:25104068]
60. Ahmad Farooq,Rafaz Hoque,Xinshou Ouyang,Ahsan Farooq,Ayaz Ghani,Kaimul Ahsan,Mateus Guerra,Wajahat Zafar Mehal.  (2014-08-12)  Activation of N-methyl-d-aspartate receptor downregulates inflammasome activity and liver inflammation via a β-arrestin-2 pathway..  American journal of physiology. Gastrointestinal and liver physiology,  307  ((7)): (G732-G740).  [PMID:25104498]
61. Oliver Wahl,Ulrike Holzgrabe.  (2014-09-30)  Evaluation of enantiomeric purity of magnesium-L-aspartate dihydrate..  Journal of pharmaceutical and biomedical analysis,  102  (100-109).  [PMID:25262412]
62. Heidi Turkia,Heli Sirén,Merja Penttilä,Juha-Pekka Pitkänen.  (2014-10-05)  Capillary electrophoresis with laser-induced fluorescence detection for studying amino acid uptake by yeast during beer fermentation..  Talanta,  131  (366-371).  [PMID:25281116]
63. Junbo Li,Xiaoli Yang,Jinxiang Yang,Lina Lai.  (2014-10-28)  Study on the interaction between ligustrazine and 12-tungstophosphoric acid using resonance Rayleigh scattering and resonance nonlinear scattering spectra, and its analytical applications..  Luminescence : the journal of biological and chemical luminescence,  30  ((5)): (643-648).  [PMID:25345883]
64. Alena Fedarovich,Edward Cook,Joshua Tomberg,Robert A Nicholas,Christopher Davies.  (2014-11-19)  Structural effect of the Asp345a insertion in penicillin-binding protein 2 from penicillin-resistant strains of Neisseria gonorrhoeae..  Biochemistry,  53  ((48)): (7596-7603).  [PMID:25403720]
65. Mizuki Kuboki,Ayumi Ito,Siro Simizu,Kazuo Umezawa.  (2014-12-17)  Activation of apoptosis by caspase-3-dependent specific RelB cleavage in anticancer agent-treated cancer cells: involvement of positive feedback mechanism..  Biochemical and biophysical research communications,  456  ((3)): (810-814).  [PMID:25511695]
66. Ming Li,Fenghe Niu,Xilin Zhu,Xiaopan Wu,Ning Shen,Xiaozhong Peng,Ying Liu.  (2015-04-29)  PRRT2 Mutant Leads to Dysfunction of Glutamate Signaling..  International journal of molecular sciences,  16  ((5)): (9134-9151).  [PMID:25915028]
67. Masashi Adachi,Yuta Hinatsu,Kosuke Kusamori,Hidemasa Katsumi,Toshiyasu Sakane,Manabu Nakatani,Koichi Wada,Akira Yamamoto.  (2015-05-20)  Improved dissolution and absorption of ketoconazole in the presence of organic acids as pH-modifiers..  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences,  76  (225-230).  [PMID:25988287]
68. Bin Cao,Zhenhua Li,Rong Peng,Jiandong Ding.  (2015-06-27)  Effects of cell-cell contact and oxygen tension on chondrogenic differentiation of stem cells..  Biomaterials,  64  (21-32).  [PMID:26113183]
69. Hao Tang,Yuping Tang,Nian-Guang Li,Hang Lin,Weixia Li,Qianping Shi,Wei Zhang,Pengxuan Zhang,Zexi Dong,Minzhe Shen,Ting Gu,Jin-Ao Duan.  (2015-07-07)  Comparative Metabolomic Analysis of the Neuroprotective Effects of Scutellarin and Scutellarein against Ischemic Insult..  PloS one,  10  ((7)): (e0131569-e0131569).  [PMID:26147971]
70. Sara Haines,Sylviane Gautheron,William Nasser,Geneviève Renauld-Mongénie.  (2015-10-31)  Identification of Novel Components Influencing Colonization Factor Antigen I Expression in Enterotoxigenic Escherichia coli..  PloS one,  10  ((10)): (e0141469-e0141469).  [PMID:26517723]
71. Fabian Istel,Tobias Schwarzmüller,Michael Tscherner,Karl Kuchler.  (2015-07-20)  Large-scale Phenotypic Profiling of Gene Deletion Mutants in Candida glabrata..  Bio-protocol,  ((14)):   [PMID:27774498]
72. Christoph B Messner,Paul C Driscoll,Gabriel Piedrafita,Michael F L De Volder,Markus Ralser.  (2017-06-28)  Nonenzymatic gluconeogenesis-like formation of fructose 1,6-bisphosphate in ice..  Proceedings of the National Academy of Sciences of the United States of America,  114  ((28)): (7403-7407).  [PMID:28652321]
73. Song Yi,Ning-Ning Liu,Limei Hu,Hui Wang,Nidhi Sahni.  (2017-10-06)  Base-resolution stratification of cancer mutations using functional variomics..  Nature protocols,  12  ((11)): (2323-2341).  [PMID:28981122]
74. Rachael M Giersch,Gregory C Finnigan.  (2017-10-31)  Method for Multiplexing CRISPR/Cas9 in Saccharomyces cerevisiae Using Artificial Target DNA Sequences..  Bio-protocol,  ((18)):   [PMID:29082289]
75. Kelsey H Fisher-Wellman,Michael T Davidson,Tara M Narowski,Chien-Te Lin,Timothy R Koves,Deborah M Muoio.  (2018-09-27)  Mitochondrial Diagnostics: A Multiplexed Assay Platform for Comprehensive Assessment of Mitochondrial Energy Fluxes..  Cell reports,  24  ((13)): (3593-3606).  [PMID:30257218]
76. Amy E Vincent,Kathryn White,Tracey Davey,Jonathan Philips,R Todd Ogden,Conor Lawless,Charlotte Warren,Matt G Hall,Yi Shiau Ng,Gavin Falkous,Thomas Holden,David Deehan,Robert W Taylor,Doug M Turnbull,Martin Picard.  (2019-01-19)  Quantitative 3D Mapping of the Human Skeletal Muscle Mitochondrial Network..  Cell reports,  26  ((4)): (996-1009).  [PMID:30655224]
77. Aleksandra Agapova,Agnese Serafini,Michael Petridis,Debbie M Hunt,Acely Garza-Garcia,Charles D Sohaskey,Luiz Pedro Sório de Carvalho.  (2019-02-01)  Flexible nitrogen utilisation by the metabolic generalist pathogen Mycobacterium tuberculosis..  eLife,    [PMID:30702426]
78. Kelsey H Fisher-Wellman,James A Draper,Michael T Davidson,Ashley S Williams,Tara M Narowski,Dorothy H Slentz,Olga R Ilkayeva,Robert D Stevens,Gregory R Wagner,Rami Najjar,Mathew D Hirschey,J Will Thompson,David P Olson,Daniel P Kelly,Timothy R Koves,Paul A Grimsrud,Deborah M Muoio.  (2019-02-07)  Respiratory Phenomics across Multiple Models of Protein Hyperacylation in Cardiac Mitochondria Reveals a Marginal Impact on Bioenergetics..  Cell reports,  26  ((6)): (1557-1572).  [PMID:30726738]
79. Hunter Cuchiaro,Lieve M L Laurens.  (2019-04-25)  Total Protein Analysis in Algae via Bulk Amino Acid Detection: Optimization of Amino Acid Derivatization after Hydrolysis with O-Phthalaldehyde 3-Mercaptopropionic Acid (OPA-3MPA)..  Journal of agricultural and food chemistry,  67  ((19)): (5672-5679).  [PMID:31017433]
80. Alex J Bott,Jianliang Shen,Claudia Tonelli,Le Zhan,Nithya Sivaram,Ya-Ping Jiang,Xufen Yu,Vrushank Bhatt,Eric Chiles,Hua Zhong,Sara Maimouni,Weiwei Dai,Stephani Velasquez,Ji-An Pan,Nathiya Muthalagu,Jennifer Morton,Tracy G Anthony,Hui Feng,Wouter H Lamers,Daniel J Murphy,Jessie Yanxiang Guo,Jian Jin,Howard C Crawford,Lanjing Zhang,Eileen White,Richard Z Lin,Xiaoyang Su,David A Tuveson,Wei-Xing Zong.  (2019-10-31)  Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism..  Cell reports,  29  ((5)): (1287-1298).  [PMID:31665640]
81. E Vezzoli,C Calì,M De Roo,L Ponzoni,E Sogne,N Gagnon,M Francolini,D Braida,M Sala,D Muller,A Falqui,P J Magistretti.  (2019-12-07)  Ultrastructural Evidence for a Role of Astrocytes and Glycogen-Derived Lactate in Learning-Dependent Synaptic Stabilization..  Cerebral cortex (New York, N.Y. : 1991),  30  ((4)): (2114-2127).  [PMID:31807747]
82. Ashley S Williams,Timothy R Koves,Michael T Davidson,Scott B Crown,Kelsey H Fisher-Wellman,Maria J Torres,James A Draper,Tara M Narowski,Dorothy H Slentz,Louise Lantier,David H Wasserman,Paul A Grimsrud,Deborah M Muoio.  (2019-12-10)  Disruption of Acetyl-Lysine Turnover in Muscle Mitochondria Promotes Insulin Resistance and Redox Stress without Overt Respiratory Dysfunction..  Cell metabolism,  31  ((1)): (131-147).  [PMID:31813822]
83. Arif Yurdagul,Manikandan Subramanian,Xiaobo Wang,Scott B Crown,Olga R Ilkayeva,Lancia Darville,Gopi K Kolluru,Christina C Rymond,Brennan D Gerlach,Ze Zheng,George Kuriakose,Christopher G Kevil,John M Koomen,John L Cleveland,Deborah M Muoio,Ira Tabas.  (2020-02-01)  Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury..  Cell metabolism,  31  ((3)): (518-533).  [PMID:32004476]
84. Wen-Jing Ren,Jia Fu,Hai-Yan Yin,Neng-Gui Xu,Chun-Zhi Tang,Li-Zhou Liu,Shu-Guang Yu,Yong Tang.  (2020-05-19)  CBS-Induced H2S Generation in Hippocampus Inhibits EA-Induced Analgesia..  Evidence-based complementary and alternative medicine : eCAM,  2020  (5917910-5917910).  [PMID:32419814]
85. Eran Mick,Denis V Titov,Owen S Skinner,Rohit Sharma,Alexis A Jourdain,Vamsi K Mootha.  (2020-05-29)  Distinct mitochondrial defects trigger the integrated stress response depending on the metabolic state of the cell..  eLife,    [PMID:32463360]
86. Thomas Montavon,Nicholas Shukeir,Galina Erikson,Bettina Engist,Megumi Onishi-Seebacher,Devon Ryan,Yaarub Musa,Gerhard Mittler,Alexandra Graff Meyer,Christel Genoud,Thomas Jenuwein.  (2021-07-18)  Complete loss of H3K9 methylation dissolves mouse heterochromatin organization..  Nature communications,  12  ((1)): (4359-4359).  [PMID:34272378]
87. Justin B Steinfeld,Hans R Aerni,Svetlana Rogulina,Yuchen Liu,Jesse Rinehart.  (2014-03-22)  Expanded cellular amino acid pools containing phosphoserine, phosphothreonine, and phosphotyrosine..  ACS chemical biology,  ((5)): (1104-1112).  [PMID:24646179]

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