Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Synonyms | levodopa | L-dopa | 59-92-7 | 3,4-dihydroxy-L-phenylalanine | Dopar | 3-Hydroxy-L-tyrosine | Bendopa | Larodopa | 3,4-Dihydroxyphenylalanine | Cidandopa | Dopaidan | Dopalina | Maipedopa | Dopasol | Eldopal | Eldopar | Levopa | Prodopa | Syndopa | Brocadopa | Insulamina | Deadopa | Pardopa | (-)-Dopa |
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Specifications & Purity | Moligand™, analytical standard, ≥99% |
Shipped In | Normal |
Grade | analytical standard, Moligand™ |
Action Type | AGONIST |
Mechanism of action | Agonist of GPR143 |
Product Description | Levodopa is a natural form of DOPA used in the treatment of Parkinson's disease. Immediate precursor of dopamine and product of tyrosine hydroxylase. |
ALogP | -2.7 |
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IUPAC Name | (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid |
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INCHI | InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1 |
InChi Key | WTDRDQBEARUVNC-LURJTMIESA-N |
Canonical SMILES | C1=CC(=C(C=C1CC(C(=O)O)N)O)O |
Isomeric SMILES | C1=CC(=C(C=C1C[C@@H](C(=O)O)N)O)O |
WGK Germany | 3 |
RTECS | AY5600000 |
PubChem CID | 6047 |
Molecular Weight | 197.19 |
Beilstein | 2215169 |
Reaxy-Rn | 2215169 |
DrugBank Ligand | DB01235 |
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ChEBI | CHEBI:15765 |
Wikipedia | L-DOPA |
CAS Registry No. | 59-92-7 |
PubChem CID | 6047 |
ChEMBL Ligand | CHEMBL1009 |
RCSB PDB Ligand | DAH |
PEP | levodopa |
DrugCentral Ligand | 1567 |
GPCRdb Ligand | levodopa |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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K2329198 | Certificate of Analysis | Dec 05, 2023 | D111049 |
K2329199 | Certificate of Analysis | Dec 05, 2023 | D111049 |
L2308024 | Certificate of Analysis | Dec 05, 2023 | D111049 |
B2217189 | Certificate of Analysis | Nov 14, 2023 | D111049 |
Solubility | Slightly soluble in water, insoluble in ethanol, chloroform or ether; easily soluble in dilute acid |
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Specific Rotation[α] | -12 ° (C=5, 1mol/L HCl) |
Melt Point(°C) | 276-278°C |
Pictogram(s) | GHS08, GHS09, GHS07 |
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Signal | Danger |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H411:Toxic to aquatic life with long lasting effects H412:Harmful to aquatic life with long lasting effects H302:Harmful if swallowed H372:Causes damage to organs through prolonged or repeated exposure H361:Suspected of damaging fertility or the unborn child |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | AY5600000 |
Reaxy-Rn | 2215169 |
Merck Index | 5464 |
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2. Tian Lin, Cheng Cheng, Zhao Zhenwen, Liu Wei, Qi Li. (2023) Colorimetric Recognition of 3,4-Dihydroxy-D,L-phenylalanine with Tetrapeptide-modified Copper Nanoparticles as Chiral Nanozymes. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 39 (6): (1092-1099). [PMID:11848474] |
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7. Ying Zhou, Min Tian, Ruichun Li, Yan Zhang, Guomei Zhang, Caihong Zhang, Shaomin Shuang. (2023) Ultrasensitive Electrochemical Platform for Dopamine Detection Based on CoNi-MOF@ERGO Composite. ACS Biomaterials Science & Engineering, 9 (10): (5599–5609). [PMID:37656436] |
8. Jin Chen, Zhuangwei Zhang, Huihui Li, Hongjin Tang. (2023) Exploring the effect of a series of flavonoids on tyrosinase using integrated enzyme kinetics, multispectroscopic, and molecular modelling analyses. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 252 (126451). [PMID:37619686] |
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13. Feng Yang, Jiayu Wei, Shihui Qiu, Chengbao Liu, Li Cheng, Haichao Zhao. (2020) Poly-levodopa as an Eco-friendly Corrosion Inhibitor for Q235 Steel. International Journal of Electrochemical Science, 15 (12302). [PMID:] |
14. Yile Hu, Hui Yang, Wei Li, Keke Du, Simin Song, Wenhui Zhang, Zhiqiang Wei, Sanqiang Li. (2021) Screen-printed Electrochemical Sensor Based on Reduced Graphene doped Poly (L-dopa)/PEDOT:PSS Composites for Epinephrine Detection. International Journal of Electrochemical Science, 16 (211224). [PMID:] |
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31. Peng Wenping, Wang Nan, Wang Shunmin, Wang Junzhen, Bian Zixiu. (2023) Effects of microwave and exogenous l-phenylalanine treatment on phenolic constituents, antioxidant capacity and enzyme inhibitory activity of Tartary buckwheat sprouts. FOOD SCIENCE AND BIOTECHNOLOGY, 32 (1): (11-19). [PMID:36606090] |
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33. Wenjing Liu, Yuanyuan Yu, Wei Cheng, Man Zhou, Li Cui, Ping Wang, Qiang Wang. (2022) Melanin-like nanoparticles loaded with Ag NPs for rapid photothermal sterilization and daily protection of textiles. COLLOIDS AND SURFACES B-BIOINTERFACES, 219 (112829). [PMID:36137339] |
34. Bingying Yu, Kegang Wu, Xuejuan Duan, Tong Zhang, Dong He, Xianghua Chai. (2022) Composition analysis and tyrosinase inhibitory activity of Cinnamomum cassia Presl leaf hydrosol and Cymbopogon citratus (DC.) Stapf leaf hydrosol. JOURNAL OF FOOD PROCESSING AND PRESERVATION, 46 (11): (e17058). [PMID:] |
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51. Xiaohui Niu, Simeng Yan, Jinliang Chen, Hongxia Li, Kunjie Wang. (2022) Enantioselective recognition of L/D-amino acids in the chiral nanochannels of a metal-organic framework. ELECTROCHIMICA ACTA, 405 (139809). [PMID:] |
52. Zhuxian Wang, Yaqi Xue, Quanfu Zeng, Zhaoming Zhu, Yuan Wang, Yufan Wu, Chunyan Shen, Hongxia Zhu, Cuiping Jiang, Li Liu, Qiang Liu. (2022) Glycyrrhiza acid-Licochalcone A complexes for enhanced bioavailability and anti-melanogenic effect of Licochalcone A: cellular uptake and in vitro experiments. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 68 (103037). [PMID:] |
53. Yuefang Sun, Lei Zhou, Tao Liao, Junping Liu, Kaibo Yu, Liqiang Zou, Wei Zhou, Wei Liu. (2022) Comparing the effect of benzoic acid and cinnamic acid hydroxyl derivatives on polyphenol oxidase: activity, action mechanism, and molecular docking. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 102 (9): (3771-3780). [PMID:34921410] |
54. Zongyan Quan, Fei Xue, Haoyuan Li, Zhiping Chen, Lei Wang, Hongxiang Zhu, Chunlin Pang, Hui He. (2022) A bioinspired ratiometric fluorescence probe based on cellulose nanocrystal-stabilized gold nanoclusters for live-cell and zebrafish imaging of highly reactive oxygen species. CHEMICAL ENGINEERING JOURNAL, 431 (133954). [PMID:] |
55. Zheng-Hao Yin, Yuan-Fei Li, Hong-Xia Gan, Nan Feng, Yong-Ping Han, Li-Mei Li. (2022) Synergistic effects and antityrosinase mechanism of four plant polyphenols from Morus and Hulless Barley. FOOD CHEMISTRY, 374 (131716). [PMID:34875434] |
56. Xiang Liu, Jinqiu Rao, Kai Wang, Meijun Wang, Tie Yao, Feng Qiu. (2021) Highly Potent Inhibition of Tyrosinase by Mulberrosides and the Inhibitory Mechanism in Vitro. CHEMISTRY & BIODIVERSITY, 19 (1): (e202100740). [PMID:34752017] |
57. Liling Wang, Yuchuan Qin, Yanbin Wang, Yifeng Zhou, Bentong Liu, Minge Bai, Xiaoqing Tong, Ru Fang, Xubo Huang. (2021) Inhibitory mechanism of two homoisoflavonoids from Ophiopogon japonicus on tyrosinase activity: insight from spectroscopic analysis and molecular docking. RSC Advances, 11 (54): (34343-34354). [PMID:35497266] |
58. Lilin Tang,Wenpeng Zhang,Haiyan Zhao,Zilin Chen. (2015-06-04) Tyrosinase inhibitor screening in traditional Chinese medicines by electrophoretically mediated microanalysis.. Journal of separation science, 38 ((16)): (2887-2892). [PMID:26037533] |
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58. Lilin Tang,Wenpeng Zhang,Haiyan Zhao,Zilin Chen. (2015-06-04) Tyrosinase inhibitor screening in traditional Chinese medicines by electrophoretically mediated microanalysis.. Journal of separation science, 38 ((16)): (2887-2892). [PMID:26037533] |