Basic Description

Synonyms	L-glutamine \| glutamine \| 56-85-9 \| Levoglutamide \| L-(+)-Glutamine \| Glutamic acid amide \| Cebrogen \| Stimulina \| (S)-2,5-Diamino-5-oxopentanoic acid \| glumin \| H-Gln-OH \| Levoglutamid \| glutamic acid 5-amide \| L-Glutamide \| 2-aminoglutaramic acid \| Glavamin \| Miglu-P \| Nutrestore \| Safori
Specifications & Purity	Moligand™, Animal Free, USP, for cell culture, ≥99%
Biochemical and Physiological Mechanisms	Glutamine provides the necessary nitrogen, carbon and the reducing equivalents required for cell growth and division during cell culture. L-Glutamic acid aids the incorporation of NH 4 + into biomolecules. L-Glutamine is an essential amino acid that i
Grade	Animal Free, for cell culture, Moligand™, USP
Product Description	Gene Information rat ... Ggt1(116568) Application L-Glutamine has been used as one of the components for the preparation of calcium-free mCZB medium. It has also been used as a supplement in a culture medium for rat hippocampal slices.

Associated Targets(Human)

GPRC6A Tchem G-protein coupled receptor family C group 6 member A 1 Activities

Discover Target: GPRC6A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Carbonic anhydrase II 17698 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Carbonic anhydrase I 13240 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Cerebroside-sulfatase 655 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Arachidonate 15-lipoxygenase 7108 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Neutral amino acid transporter A 18 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Cytochrome P450 3A4 53859 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Homo sapiens 32628 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Flap endonuclease 1 12055 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 93046 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Bloom syndrome protein 4248 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Peripheral myelin protein 22 699 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Histone-lysine N-methyltransferase MLL 17327 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Neutral amino acid transporter B(0) 65 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Histone deacetylase 6 222 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasmodium falciparum 966862 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Canis familiaris 36305 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Replicase polyprotein 1ab 378 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

6-phospho-1-fructokinase 7870 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Thioredoxin reductase 1, cytoplasmic 45279 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Glutamate NMDA receptor 6467 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Monocarboxylate transporter 10 73 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Amino acid transporter 271 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Asc-type amino acid transporter 1 14 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Carbonic anhydrase-like protein, putative 25 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 38078 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	(2S)-2,5-diamino-5-oxopentanoic acid
INCHI	InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1
InChi Key	ZDXPYRJPNDTMRX-VKHMYHEASA-N
Canonical SMILES	C(CC(=O)N)C(C(=O)O)N
Isomeric SMILES	C(CC(=O)N)[C@@H](C(=O)O)N
WGK Germany	1
RTECS	MA2275100
PubChem CID	5961
Molecular Weight	146.15
Beilstein	4491
Reaxy-Rn	1723797

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

7 results found

Lot Number	Certificate Type	Date	Item
E23291224	Certificate of Analysis	Mar 29, 2023	L432948
E23291229	Certificate of Analysis	Mar 29, 2023	L432948
E23291236	Certificate of Analysis	Mar 29, 2023	L432948
E23291237	Certificate of Analysis	Mar 29, 2023	L432948
E23291239	Certificate of Analysis	Mar 29, 2023	L432948
E23291269	Certificate of Analysis	Mar 29, 2023	L432948
E2406067	Certificate of Analysis	Mar 29, 2023	L432948

Chemical and Physical Properties

Solubility	H2O: 25mg/mL
Specific Rotation[α]	6.8 ° (C=4, H2O)
Melt Point(°C)	185-186°C

Safety and Hazards(GHS)

WGK Germany	1
RTECS	MA2275100
Reaxy-Rn	1723797
Merck Index	4471

Alternative Products

FAQs and Articles

FAQ

Synthesis and Metabolism of Glutamate and GABA: Core Mechanisms of Neurotransmitters

Categories: Technical articles

Tags:

Building Blocks Amino acids Vitamins GABA Metabolites Neurotransmitters Glutamate Glutamate/GABA metabolism Neural signaling pathways

Citations of This Product

1. Lixia Liu, Bingqing Liu, Yongbing Hao, Jia Wang, Xiufang Xu, Xuefang Shang. (2024) Theory and experiment: The synthesis and drug application of “ON-OFF-ON” fluorescent probes for copper and biothiols detection. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 239 (12): (115876). [PMID:38039872]
2. Qiankun Quan, Xinxin Ma, Ming Li, Xi Li, Haifeng Yuan. (2024) Ginsenoside Rg1 promotes β‑amyloid peptide degradation through inhibition of the ERK/PPARγ phosphorylation pathway in an Alzheimer's disease neuronal model. Experimental and Therapeutic Medicine, 27 (1): (1-13). [PMID:38125359]
3. Ting Liu, Ling Wang, Yang Yu, Zhuo Zhang, Zelong Duan, Yawen Li, Chencan Li. (2024) Adenosine Triphosphatase-Stabilized ZIF-67 as Peroxidase Mimic for Rapid Detection of Glutathione. INORGANIC CHEMISTRY COMMUNICATIONS, 159 (1): (111705). [PMID:14612514]
4. Lvyuan Fan, Zhiyu Pan, Yilin Zhong, Juan Guo, Xu Liao, Rui Pang, Qingqiang Xu, Guozhu Ye, Yubin Su. (2023) L-glutamine sensitizes Gram-positive-resistant bacteria to gentamicin killing. Microbiology Spectrum, 11 (6): [PMID:37882580]
5. Pan Jun, Cai Youzhi, Zhang Chi, Xu Sanzhong. (2023) Intra-articular delivery of geraniol encapsulated by pH/redox-responsive nanogel ameliorates osteoarthritis by regulating oxidative stress and inflammation. JOURNAL OF MOLECULAR HISTOLOGY, (1-13). [PMID:37848748]
6. Yanan Li, Pingping Dong, Long Dai, Shaoping Wang. (2023) Untargeted and Targeted Metabolomics Reveal the Active Peptide of Eupolyphaga sinensis Walker against Hyperlipidemia by Modulating Imbalance in Amino Acid Metabolism. MOLECULES, 28 (20): (7049). [PMID:37894528]
7. Li Liu, Yu-Han Lu, Min-Dan Wang, Qun-Fei Zhao, Xiu-Ping Chen, Hang Yin, Chen-Guo Feng, Fang Zhang. (2023) DMMIC derivatization-assisted liquid chromatography-mass spectrometry method for metabolite profiling of the glutathione anabolic pathway in esophageal cancer tissues and cells. Journal of Pharmaceutical Analysis, 13 (23): (1365). [PMID:38174115]
8. Zhihong Wang, Taifeng Li, Ruisheng Li, Bo Cao, Shiyuan Wang, Xiaofei Fei, Chunyu Li, Guohui Li. (2023) Sijunzi Tang improves gefitinib resistance by regulating glutamine metabolism. BIOMEDICINE & PHARMACOTHERAPY, 167 (3): (115438). [PMID:37738796]
9. Wengan Zhang, Binjie Chen, Ruke Wang, Jing Liu, Bo Wang. (2023) Peroxidase-like Nanozyme Composite-based Colorimetric Determination of Glutathione and Cysteine. ANALYTICAL LETTERS, [PMID:]
10. Zuwei Fu, Qionghai Chen, Junwei He, Sai Li, Rui Ming, Yuan Wei, Yihui Xu, Jun Liu, Liqun Zhang. (2023) A synergistic effect of MXene/MWCNT enables self-healable and low percolation elastomer sensor: A combined experiment and all-atom molecular dynamics simulation. COMPOSITES SCIENCE AND TECHNOLOGY, 242 (110155). [PMID:]
11. Yu Zheng, Xinyi Li, Caixia Wei, Yawen Gao, Guangmei Han, Jun Zhao, Cheng Zhang, Kui Zhang, Zhongping Zhang. (2023) Long-Lived Phosphorescent Carbon Dots as Photosensitizers for Total Antioxidant Capacity Assay. ANALYTICAL CHEMISTRY, 95 (23): (8914–8921). [PMID:37246518]
12. Jia-Nan Chen, Yu-Ying Zhang, Xu-Hui Huang, Meng Dong, Xiu-Ping Dong, Da-Yong Zhou, Bei-Wei Zhu, Lei Qin. (2023) Integrated volatolomics and metabolomics analysis reveals the characteristic flavor formation in Chouguiyu, a traditional fermented mandarin fish of China. FOOD CHEMISTRY, 418 (135874). [PMID:36963134]
13. Anqi Peng, Keke Yu, Shuwei Yu, Yingying Li, Hao Zuo, Ping Li, Juan Li, Jianan Huang, Zhonghua Liu, Jian Zhao. (2023) Aluminum and Fluoride Stresses Altered Organic Acid and Secondary Metabolism in Tea (Camellia sinensis) Plants: Influences on Plant Tolerance, Tea Quality and Safety. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (5): (4640). [PMID:36902071]
14. Dingding Liu, Kang Wei, Chenyu Zhang, Haoran Liu, Yang Gong, Yuanyuan Ye, Jiedan Chen, Mingzhe Yao, Liang Chen, Chunlei Ma. (2023) The potential effects of chlorophyll-deficient mutation and tree_age on the accumulation of amino acid components in tea plants. FOOD CHEMISTRY, 411 (135527). [PMID:36701915]
15. Xin Wang, Changjian Zhu, Xuerong Yan, Sijie Cheng, Yong Zhang. (2023) The synthesis of N-doped carbon dots for visual differentiating and detection of tetracyclines. LUMINESCENCE, 38 (2): (188-195). [PMID:36630153]
16. Zhang Jing, Yang Junqing, Luo Ying, Li Jiansha, Gong Tao, Huang Suqiong, Xiong Yan, Jiang Xinhui. (2022) Determination of 23 Amino Acids and Amines in Plasma and Cortex of C57BL/6 Mice with HPLC–FLD. JOURNAL OF CHROMATOGRAPHIC SCIENCE, [PMID:36572394]
17. Jia-Xiang Xin, Da-Xiu Wei, Yan Ren, Jun-Long Wang, Guang Yang, Huojun Zhang, Jianqi Li, Caixia Fu, Ye-Feng Yao. (2022) Distinguishing glutamate and glutamine in in vivo 1H MRS based on nuclear spin singlet order filtering. MAGNETIC RESONANCE IN MEDICINE, 89 (5): (1728-1740). [PMID:36572961]
18. Fangning Liu, Zhe Li, Ge Kang, Zhai Liu, Shicheng Zhu, Ruxue He, Chenghui Zhang, Chuanxia Chen, Yizhong Lu. (2023) Ratiometric sensing of α-glucosidase and its inhibitor based on MnO2 nanosheets promoted in-situ fluorescent reactions. MICROCHEMICAL JOURNAL, 186 (108352). [PMID:]
19. Xin Huang, Rui Wang, Yikai Wang, Changbao Chen, Shuying Liu. (2023) Investigation on property differences of ginseng and American ginseng by spatial metabolomics of neurochemicals with desorption electrospray ionization mass spectrometry imaging. JOURNAL OF ETHNOPHARMACOLOGY, 303 (116006). [PMID:36516905]
20. Lin Yuan, Lei Jiang, Ze Liu, Yingying Xiang, Fei Song, Yujiao Tu. (2023) Selective and sensitive simultaneous detection of tartrazine and Hg2+ based on N-doped yellow-green fluorescent carbon dots. DYES AND PIGMENTS, 209 (110893). [PMID:]
21. Meijuan Zhang, Jian Cao, Cuiping Huang, Mingming Liu, Yanan Li, Chuanxiao Wang, Yajing Tu. (2023) A fluorescent molecular sensor based on 1,8-naphthalimide for sensitive and rapid detection of human serum albumin. DYES AND PIGMENTS, 208 (110867). [PMID:]
22. Jie Xiang, Junyi Zhang, Shunmei Li, Ruo Yuan, Yun Xiang. (2022) Aptamer-based and sensitive label-free colorimetric sensing of phenylalanine via cascaded signal amplifications. ANALYTICA CHIMICA ACTA, 1230 (340393). [PMID:36192064]
23. Peng Fangfang, Zhou Xin, Cheng Wanmin, Ma Jimei, Jiang Hong. (2022) A Carbon Dots Probe for Specific Determination of Cysteine based on Inner Filter Effect. JOURNAL OF ANALYTICAL CHEMISTRY, 77 (9): (1141-1146). [PMID:]
24. Yiyi Liu, Fangling Wu, Jiabin Wang, Ling Pu, Chuan-Fan Ding. (2022) Simultaneous chirality separation of amino acids and their derivative by natamycin based on mobility measurements. ANALYTICA CHIMICA ACTA, 1227 (340298). [PMID:36089312]
25. Wei Wang, Jiandan Chen, Zhenzeng Zhou, Shanshan Zhan, Zhiyuan Xing, Hongying Liu, Linan Zhang. (2022) Ultrasensitive and Selective Detection of Glutathione by Ammonium Carbamate–Gold Platinum Nanoparticles-Based Electrochemical Sensor. Life-Basel, 12 (8): (1142). [PMID:36013320]
26. Lei Cao, Mengyan Zhou, Jiaxi Wang, Qiang Zhu, Tingting Liu, Shushu Ding, Ding-Yi Fu. (2022) Gold–Silver Bimetallic Nanoclusters Protected by Glutathione S-Transferase for Colorimetric Sensing of Oxytetracycline. ACS Applied Nano Materials, 5 (8): (11176–11184). [PMID:]
27. Yingying Xiang, Yujiao Tu, Lei Jiang, Lin Yuan, Ze Liu, Qiang Xie, Xuequan Xiong, Fei Song. (2022) Orange fluorescent dual-mode nanoprobe for selective and sensitive detection of amaranth based on S,N-Doped carbon dots. DYES AND PIGMENTS, 205 (110533). [PMID:]
28. Jing Zhang, Jun-qing Yang, Ying Luo, Jian-sha Li, Tao Gong, Su-qiong Huang, Yan Xiong, Xin-hui Jiang. (2022) Determination of 23 related analytes in bone marrow fluid and hippocampus of C57BL/6 mice following cerebral ischemia–reperfusion injury by HPLC-FLD. BIOMEDICAL CHROMATOGRAPHY, 36 (10): (e5435). [PMID:35763335]
29. Wang Ying, Li ZhiRong, Chen RongXiang. (2022) Simultaneous Determination of Metabolites Related to Arginine Metabolism in Rat plasma by Hydrophilic Interaction Chromatography–Tandem Mass Spectrometry. JOURNAL OF CHROMATOGRAPHIC SCIENCE, 61 (3): (203-210). [PMID:35704851]
30. Meiying Yang, Xueqing Jin, Wenna Huang, Qi Shen, Chunyan Sun. (2022) Humic acid induced indirect photolysis of polybrominated diphenyl ethers under visible light irradiation. Journal of Environmental Chemical Engineering, 10 (108002). [PMID:]
31. Wenjing Wang, Yumin He, Yunling Gao, Hongrui Gao, Lei Deng, Qingwen Gui, Zhong Cao, Yulong Yin, Zemeng Feng. (2022) A peptide aptamer based electrochemical amperometric sensor for sensitive L-glutamate detection. BIOELECTROCHEMISTRY, 146 (108165). [PMID:35623273]
32. Jing Li, Yao Zhang, Zhichao Lou, Mingxi Li, Lin Cui, Zhenrong Yang, Lijuan Zhang, Yu Zhang, Ning Gu, Fang Yang. (2022) Magnetic Nanobubble Mechanical Stress Induces the Piezo1-Ca2+-BMP2/Smad Pathway to Modulate Neural Stem Cell Fate and MRI/Ultrasound Dual Imaging Surveillance for Ischemic Stroke. Small, 18 (23): (2201123). [PMID:35555970]
33. Cheng Yuan-Qiu, Yue Yu-Xin, Cao Hong-Mei, Geng Wen-Chao, Wang Lan-Xing, Hu Xin-Yue, Li Hua-Bin, Bian Qiang, Kong Xiang-Lei, Liu Jian-Feng, Kong De-Ling, Guo Dong-Sheng, Wang Yue-Bing. (2021) Coassembly of hypoxia-sensitive macrocyclic amphiphiles and extracellular vesicles for targeted kidney injury imaging and therapy. JOURNAL OF NANOBIOTECHNOLOGY, 19 (1): (1-21). [PMID:34961540]
34. Zhiwei Qiu, Jinzhao He, Guangying Shao, Jiaqi Hu, Xiaowei Li, Hong Zhou, Min Li, Baoxue Yang. (2022) Obacunone Retards Renal Cyst Development in Autosomal Dominant Polycystic Kidney Disease by Activating NRF2. Antioxidants, 11 (1): (38). [PMID:35052542]
35. Mengyu Chen, Jingdan Zhang, Jianyu Chang, Huiya Li, Yongqing Zhai, Zhenguang Wang. (2022) Ultrasensitive detection of butyrylcholinesterase activity based on self-polymerization modulated fluorescence of sulfur quantum dots. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 269 (120756). [PMID:34952437]
36. You Dou, Ran Yang, Yue Xiao, Jiao Wu, Lingbo Qu, Yuanqiang Sun, Zhaohui Li. (2022) Teaching a fluorophore new tricks: Exploiting the light-driven organic oxidase nanozyme properties of thiazolothiazole for highly sensitive biomedical detection. SENSORS AND ACTUATORS B-CHEMICAL, 354 (131226). [PMID:]
37. Shuang Yu, Wentao Shi, Shadi Houshyar, Xin Wang, Pibo Ma. (2021) Preparation and performances of coated polypropylene hernia mesh with natural biomaterials. Colloid and Interface Science Communications, 45 (100535). [PMID:]
38. Ma Jinzhu, Ma Lili, Cao Lili, Miao Yuming, Dong Jiangxue, Shi Yu-e, Wang Zhenguang. (2021) Point-of-care testing of butyrylcholinesterase activity through modulating the photothermal effect of cuprous oxide nanoparticles. MICROCHIMICA ACTA, 188 (11): (1-8). [PMID:34697648]
39. Li-Xin Ma, Xu-Hui Huang, Jie Zheng, Liu Dong, Jia-Nan Chen, Xiu-Ping Dong, Da-Yong Zhou, Bei-Wei Zhu, Lei Qin. (2022) Free amino acid, 5′-Nucleotide, and lipid distribution in different tissues of blue mussel (Mytilis edulis L.) determined by mass spectrometry based metabolomics. FOOD CHEMISTRY, 373 (131435). [PMID:34741971]
40. Huiyi Yang, Qiyi He, Junkang Pan, Mingxia Lin, Zhiting Lao, Qinglan Li, Xiping Cui, Suqing Zhao. (2022) PtCu nanocages with superior tetra-enzyme mimics for colorimetric sensing and fluorescent sensing dehydroepiandrosterone. SENSORS AND ACTUATORS B-CHEMICAL, 351 (130905). [PMID:]
41. Yu-Cai He,Dan-Ping Zhang,Zhi-Cheng Tao,Yun Lu,Yun Ding,Feng Liu,Zheng-Zhong Zhu,Huan Rui,Gao-Wei Zheng,Xian Zhang. (2015-02-16) Improved biosynthesis of ethyl (S)-4-chloro-3-hydroxybutanoate by adding L-glutamine plus glycine instead of NAD+ in β-cyclodextrin-water system.. Bioresource technology, 182 (98-102). [PMID:25682229]
42. Wanshu Qi,Qing Guan,Tuanqi Sun,Yanjing Cao,Li Zhang,Yinlong Guo. (2015-03-31) Improving detection sensitivity of amino acids in thyroid tissues by using phthalic acid as a mobile phase additive in hydrophilic interaction chromatography-electrospray ionization-tandem mass spectrometry.. Analytica chimica acta, 870 (75-82). [PMID:25819789]

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SKU	Size	Availability	Price
L432948-25g	25g	In stock	$35.90
L432948-100g	100g	In stock	$109.90
L432948-500g	500g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$459.90

L-Glutamine - meets USP testing specifications, suitable for cell culture, 99.0-101.0%, from non-animal source, high purity , CAS No.56-85-9