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L425728-1ml

1ml

Available within 4-8 weeks(?)

$36.90

Basic Description

Synonyms	l-isoleucine \| Isoleucine \| 73-32-5 \| (2S,3S)-2-Amino-3-methylpentanoic acid \| 2S,3S-Isoleucine \| (S)-Isoleucine \| H-Ile-OH \| (S,S)-Isoleucine \| 2-Amino-3-methylvaleric acid \| L-(+)-Isoleucine \| erythro-L-Isoleucine \| L-Ile \| ISOLEUCINE, L- \| alpha-Amino-beta-methylvaleric acid \| Is
Specifications & Purity	Moligand™, 10mM in Water
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™

Associated Targets(Human)

SLC36A1 Tchem Proton-coupled amino acid transporter 1 (0 Activities)

Discover Target: SLC36A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PKM Tchem Pyruvate kinase PKM (0 Activities)

Discover Target: PKM

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC16A10 Tbio Monocarboxylate transporter 10 (0 Activities)

Discover Target: SLC16A10

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC7A5 Tchem Large neutral amino acids transporter small subunit 1 (0 Activities)

Discover Target: SLC7A5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC7A5 Tchem L-type amino acid transporter 1 (388 Activities)

Discover Target: SLC7A5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC36A1 Tchem Proton-coupled amino acid transporter 1 (102 Activities)

Discover Target: SLC36A1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Pkm Pyruvate kinase isozymes M1/M2 (66 Activities)

Discover Target: Pkm

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Slc16a10 Monocarboxylate transporter 10 (73 Activities)

Discover Target: Slc16a10

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	(2S,3S)-2-amino-3-methylpentanoic acid
INCHI	InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1
InChi Key	AGPKZVBTJJNPAG-WHFBIAKZSA-N
Canonical SMILES	CCC(C)C(C(=O)O)N
Isomeric SMILES	CC[C@H](C)[C@@H](C(=O)O)N
RTECS	NR4705000
PubChem CID	6306
Molecular Weight	131.18
Beilstein	4454
Reaxy-Rn	1721792

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Specific Rotation[α]	40.5 ° (C=4, 6mol/L HCl)
Melt Point(°C)	288 °C

Safety and Hazards(GHS)

RTECS	NR4705000
Reaxy-Rn	1721792
Merck Index	5179

Citations of This Product

1. Zhiyang Xu, Yinzhou Yan, Xingyuan Wang, Xiaolei Wang, Zhixiang Zhou, Xi Yang, Tianrui Zhai. (2023) Determination of Enantiomeric Excess by Optofluidic Microlaser near Exceptional Point. Advanced Science, (2308362). [PMID:38072636]
2. Zhen Lin, Chuangui Cai, Wei Chen, Qian Deng, Jialin Yang, Kaiyuan Huang, Haohua Deng, Xinhua Lin, Wei Chen, Wensong Yao. (2024) Micelle-mediated chemiluminescence of 6-aza-2-thiothymine-protected gold nanoclusters for carbazochrome sodium sulfonate detection. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 308 (123738). [PMID:38086230]
3. Wei Jia, Jiying Zhu. (2023) Molecular Mechanism of ε-Polylysine Treatment of Animal-Derived Foods: Glycine Amidinotransferase Activity Implicates Upregulation of l-Arginine and Creatine. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 71 (41): (15106–15120). [PMID:37793042]
4. Jierui Yang, Benqi Chen, Huiting Qiu, Shuang Meng, Yunhui Yang. (2023) Ni3V2O8 nanoflower mimetic enzyme constructs a dual-signal system for ascorbic acid detection. RSC Advances, 13 (37): (26102-26110). [PMID:37664210]
5. Wenjing Wang, Yumin He, Lei Deng, Hui Wang, Xiaoying Liu, Qing-wen Gui, Zhong Cao, Zemeng Feng, Benhai Xiong, Yulong Yin. (2023) Peptide aptamer-based polyaniline-modified amperometric biosensor for L-lysine detection in real serum samples. MEASUREMENT, 221 (113468). [PMID:]
6. Wei Jia, Xin Wang. (2023) 3-Chloropropane-1,2-diol exposure adversely influenced the bio-accessibility signatures of digested infant foods by suppressing the destabilization of α-lactalbumin and d-aspartate oxidase in a dose-dependent manner. FOOD CHEMISTRY, 427 (136729). [PMID:37385056]
7. Yichen Wang, Renjin Zheng, Pingping Wu, Youjia Wu, Lingyi Huang, Liying Huang. (2023) Determination of Multiple Neurotransmitters through LC-MS/MS to Confirm the Therapeutic Effects of Althaea rosea Flower on TTX-Intoxicated Rats. MOLECULES, 28 (10): (4158). [PMID:37241898]
8. Chonghui Wei, Xuan Xie, Yue Mou, Shiqi Cheng, Jin Yang, Kaixin Xue, Kewei Yu, Xinru Lin, Chunfen Zhang, Yujie Zhao, Xingyu Luo, Yilin Wang. (2023) Controllable synthesis of MoS2@TiO2 nanocomposites for visual detection of dopamine secretion with highly-efficient enzymatic activity. ANALYST, 148 (8): (1732-1742). [PMID:36938870]
9. Yankui Xing, Zhengda Zhou, Fangfang Li, Shuangping Tian, Yuxi Liang, Sixian Li, Yanan Zhou, Yun Gao. (2023) Solid-liquid equilibrium and dissolution thermodynamic properties of L-isoleucine in binary solvent mixtures. JOURNAL OF CHEMICAL THERMODYNAMICS, 182 (107035). [PMID:]
10. Chengxiang Chu, Xianfeng Wang, Yuanyi Deng, Yi Ma, Chengyue Zou, Mei Yang, Huibo Luo, Danqun Huo, Changjun Hou. (2023) Discrimination of Chinese green tea according to tea polyphenols using fluorescence sensor array based on Tb (III) and Eu (III) doped Zr (IV) metal–organic frameworks. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 292 (122380). [PMID:36736046]
11. Zhang Jing, Yang Junqing, Luo Ying, Li Jiansha, Gong Tao, Huang Suqiong, Xiong Yan, Jiang Xinhui. (2022) Determination of 23 Amino Acids and Amines in Plasma and Cortex of C57BL/6 Mice with HPLC–FLD. JOURNAL OF CHROMATOGRAPHIC SCIENCE, [PMID:36572394]
12. Fangning Liu, Zhe Li, Ge Kang, Zhai Liu, Shicheng Zhu, Ruxue He, Chenghui Zhang, Chuanxia Chen, Yizhong Lu. (2023) Ratiometric sensing of α-glucosidase and its inhibitor based on MnO2 nanosheets promoted in-situ fluorescent reactions. MICROCHEMICAL JOURNAL, 186 (108352). [PMID:]
13. Yujiao Tu, Ze Liu, Lei Jiang, Yingying Xiang, Fei Song, Lifen Meng, Xiuling Ji, Lin Yuan. (2023) Green ratiometric fluorescent dual-mode nanosensor for highly selective and sensitive detection of new coccine in food. DYES AND PIGMENTS, 210 (111024). [PMID:]
14. Lei Di, Shengyu Cheng, Yan Zhu, Yueying Jin, Chao Qi, Lingli Zhang, Minghui Zhang, Xin Wang, Yu Han, Xi-Ling Li, Jun Zhe Min. (2023) Development of a diphenyl sulfide structure derivatization reagent for amino acid enantiomers analysis: Application of dynamic monitoring in human urine after drinking wine. JOURNAL OF CHROMATOGRAPHY A, 1688 (463698). [PMID:36528900]
15. Lin Yuan, Lei Jiang, Ze Liu, Yingying Xiang, Fei Song, Yujiao Tu. (2023) Selective and sensitive simultaneous detection of tartrazine and Hg2+ based on N-doped yellow-green fluorescent carbon dots. DYES AND PIGMENTS, 209 (110893). [PMID:]
16. Hui Yuan, Yu Chen, Ruikang Lin, Dan Tan, Jiaojiao Zhang, Yongmei Wang, Ehud Gazit, Wei Ji, Rusen Yang. (2022) Modified Stranski–Krastanov Growth of Amino Acid Arrays toward Piezoelectric Energy Harvesting. ACS Applied Materials & Interfaces, 14 (41): (46304–46312). [PMID:36196653]
17. Hang Zhang, Jun Jiang Luo, Zhe Sun, Hao Lin Zou, Hong Qun Luo, Nian Bing Li, Bang Lin Li. (2022) Hydrogels allow the precise growth tracking of plasmonic gold nanoparticles for mercury analysis. Journal of Materials Chemistry C, 10 (39): (14508-14516). [PMID:]
18. Hai-Bin Qin, Jun-Ping Zhou, Bo Zhang, Zhi-Qiang Liu, Yu-Guo Zheng. (2022) Combing with redox regulation via quorum-sensing system and fermentation strategies for improving D-pantothenic acid production. PROCESS BIOCHEMISTRY, 121 (681). [PMID:]
19. Yingying Xiang, Yujiao Tu, Lei Jiang, Lin Yuan, Ze Liu, Qiang Xie, Xuequan Xiong, Fei Song. (2022) Orange fluorescent dual-mode nanoprobe for selective and sensitive detection of amaranth based on S,N-Doped carbon dots. DYES AND PIGMENTS, 205 (110533). [PMID:]
20. Wenjing Wang, Yumin He, Yunling Gao, Hongrui Gao, Lei Deng, Qingwen Gui, Zhong Cao, Yulong Yin, Zemeng Feng. (2022) A peptide aptamer based electrochemical amperometric sensor for sensitive L-glutamate detection. BIOELECTROCHEMISTRY, 146 (108165). [PMID:35623273]
21. Bixia Huang,Xuewen Hu,Jiancheng Wang,Ping Li,Jun Chen. (2019-04-29) Study on chemical constituents of herbal formula Er Miao Wan and GC-MS based metabolomics approach to evaluate its therapeutic effects on hyperuricemic rats.. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1118-1119 (101-108). [PMID:31030102]
22. Zhang E, Bai PY, Cui DY, Chu WC, Hua YG, Liu Q, Yin HY, Zhang YJ, Qin S, Liu HM.. (2018) Synthesis and bioactivities study of new antibacterial peptide mimics: The dialkyl cationic amphiphiles.. Eur J Med Chem, 143 (1489-1509). [PMID:29126736]

References

1. Zhiyang Xu, Yinzhou Yan, Xingyuan Wang, Xiaolei Wang, Zhixiang Zhou, Xi Yang, Tianrui Zhai. (2023) Determination of Enantiomeric Excess by Optofluidic Microlaser near Exceptional Point. Advanced Science, (2308362). [PMID:38072636]
2. Zhen Lin, Chuangui Cai, Wei Chen, Qian Deng, Jialin Yang, Kaiyuan Huang, Haohua Deng, Xinhua Lin, Wei Chen, Wensong Yao. (2024) Micelle-mediated chemiluminescence of 6-aza-2-thiothymine-protected gold nanoclusters for carbazochrome sodium sulfonate detection. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 308 (123738). [PMID:38086230]
3. Wei Jia, Jiying Zhu. (2023) Molecular Mechanism of ε-Polylysine Treatment of Animal-Derived Foods: Glycine Amidinotransferase Activity Implicates Upregulation of l-Arginine and Creatine. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 71 (41): (15106–15120). [PMID:37793042]
4. Jierui Yang, Benqi Chen, Huiting Qiu, Shuang Meng, Yunhui Yang. (2023) Ni3V2O8 nanoflower mimetic enzyme constructs a dual-signal system for ascorbic acid detection. RSC Advances, 13 (37): (26102-26110). [PMID:37664210]
5. Wenjing Wang, Yumin He, Lei Deng, Hui Wang, Xiaoying Liu, Qing-wen Gui, Zhong Cao, Zemeng Feng, Benhai Xiong, Yulong Yin. (2023) Peptide aptamer-based polyaniline-modified amperometric biosensor for L-lysine detection in real serum samples. MEASUREMENT, 221 (113468). [PMID:]
6. Wei Jia, Xin Wang. (2023) 3-Chloropropane-1,2-diol exposure adversely influenced the bio-accessibility signatures of digested infant foods by suppressing the destabilization of α-lactalbumin and d-aspartate oxidase in a dose-dependent manner. FOOD CHEMISTRY, 427 (136729). [PMID:37385056]
7. Yichen Wang, Renjin Zheng, Pingping Wu, Youjia Wu, Lingyi Huang, Liying Huang. (2023) Determination of Multiple Neurotransmitters through LC-MS/MS to Confirm the Therapeutic Effects of Althaea rosea Flower on TTX-Intoxicated Rats. MOLECULES, 28 (10): (4158). [PMID:37241898]
8. Chonghui Wei, Xuan Xie, Yue Mou, Shiqi Cheng, Jin Yang, Kaixin Xue, Kewei Yu, Xinru Lin, Chunfen Zhang, Yujie Zhao, Xingyu Luo, Yilin Wang. (2023) Controllable synthesis of MoS2@TiO2 nanocomposites for visual detection of dopamine secretion with highly-efficient enzymatic activity. ANALYST, 148 (8): (1732-1742). [PMID:36938870]
9. Yankui Xing, Zhengda Zhou, Fangfang Li, Shuangping Tian, Yuxi Liang, Sixian Li, Yanan Zhou, Yun Gao. (2023) Solid-liquid equilibrium and dissolution thermodynamic properties of L-isoleucine in binary solvent mixtures. JOURNAL OF CHEMICAL THERMODYNAMICS, 182 (107035). [PMID:]
10. Chengxiang Chu, Xianfeng Wang, Yuanyi Deng, Yi Ma, Chengyue Zou, Mei Yang, Huibo Luo, Danqun Huo, Changjun Hou. (2023) Discrimination of Chinese green tea according to tea polyphenols using fluorescence sensor array based on Tb (III) and Eu (III) doped Zr (IV) metal–organic frameworks. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 292 (122380). [PMID:36736046]
11. Zhang Jing, Yang Junqing, Luo Ying, Li Jiansha, Gong Tao, Huang Suqiong, Xiong Yan, Jiang Xinhui. (2022) Determination of 23 Amino Acids and Amines in Plasma and Cortex of C57BL/6 Mice with HPLC–FLD. JOURNAL OF CHROMATOGRAPHIC SCIENCE, [PMID:36572394]
12. Fangning Liu, Zhe Li, Ge Kang, Zhai Liu, Shicheng Zhu, Ruxue He, Chenghui Zhang, Chuanxia Chen, Yizhong Lu. (2023) Ratiometric sensing of α-glucosidase and its inhibitor based on MnO2 nanosheets promoted in-situ fluorescent reactions. MICROCHEMICAL JOURNAL, 186 (108352). [PMID:]
13. Yujiao Tu, Ze Liu, Lei Jiang, Yingying Xiang, Fei Song, Lifen Meng, Xiuling Ji, Lin Yuan. (2023) Green ratiometric fluorescent dual-mode nanosensor for highly selective and sensitive detection of new coccine in food. DYES AND PIGMENTS, 210 (111024). [PMID:]
14. Lei Di, Shengyu Cheng, Yan Zhu, Yueying Jin, Chao Qi, Lingli Zhang, Minghui Zhang, Xin Wang, Yu Han, Xi-Ling Li, Jun Zhe Min. (2023) Development of a diphenyl sulfide structure derivatization reagent for amino acid enantiomers analysis: Application of dynamic monitoring in human urine after drinking wine. JOURNAL OF CHROMATOGRAPHY A, 1688 (463698). [PMID:36528900]
15. Lin Yuan, Lei Jiang, Ze Liu, Yingying Xiang, Fei Song, Yujiao Tu. (2023) Selective and sensitive simultaneous detection of tartrazine and Hg2+ based on N-doped yellow-green fluorescent carbon dots. DYES AND PIGMENTS, 209 (110893). [PMID:]
16. Hui Yuan, Yu Chen, Ruikang Lin, Dan Tan, Jiaojiao Zhang, Yongmei Wang, Ehud Gazit, Wei Ji, Rusen Yang. (2022) Modified Stranski–Krastanov Growth of Amino Acid Arrays toward Piezoelectric Energy Harvesting. ACS Applied Materials & Interfaces, 14 (41): (46304–46312). [PMID:36196653]
17. Hang Zhang, Jun Jiang Luo, Zhe Sun, Hao Lin Zou, Hong Qun Luo, Nian Bing Li, Bang Lin Li. (2022) Hydrogels allow the precise growth tracking of plasmonic gold nanoparticles for mercury analysis. Journal of Materials Chemistry C, 10 (39): (14508-14516). [PMID:]
18. Hai-Bin Qin, Jun-Ping Zhou, Bo Zhang, Zhi-Qiang Liu, Yu-Guo Zheng. (2022) Combing with redox regulation via quorum-sensing system and fermentation strategies for improving D-pantothenic acid production. PROCESS BIOCHEMISTRY, 121 (681). [PMID:]
19. Yingying Xiang, Yujiao Tu, Lei Jiang, Lin Yuan, Ze Liu, Qiang Xie, Xuequan Xiong, Fei Song. (2022) Orange fluorescent dual-mode nanoprobe for selective and sensitive detection of amaranth based on S,N-Doped carbon dots. DYES AND PIGMENTS, 205 (110533). [PMID:]
20. Wenjing Wang, Yumin He, Yunling Gao, Hongrui Gao, Lei Deng, Qingwen Gui, Zhong Cao, Yulong Yin, Zemeng Feng. (2022) A peptide aptamer based electrochemical amperometric sensor for sensitive L-glutamate detection. BIOELECTROCHEMISTRY, 146 (108165). [PMID:35623273]
21. Bixia Huang,Xuewen Hu,Jiancheng Wang,Ping Li,Jun Chen. (2019-04-29) Study on chemical constituents of herbal formula Er Miao Wan and GC-MS based metabolomics approach to evaluate its therapeutic effects on hyperuricemic rats.. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1118-1119 (101-108). [PMID:31030102]
22. Zhang E, Bai PY, Cui DY, Chu WC, Hua YG, Liu Q, Yin HY, Zhang YJ, Qin S, Liu HM.. (2018) Synthesis and bioactivities study of new antibacterial peptide mimics: The dialkyl cationic amphiphiles.. Eur J Med Chem, 143 (1489-1509). [PMID:29126736]

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L-Isoleucine - 10mM in Water, high purity , CAS No.73-32-5