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L-Kynurenine Hydrate - 10mM in DMSO, high purity , CAS No.2922-83-0
Basic Description Synonyms L-kynurenine|2922-83-0|(S)-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid|Kynurenine, L-|3-Anthraniloyl-L-alanine|(2S)-2-amino-4-(2-aminophenyl)-4-oxobutanoic acid|CHEBI:16946|Kynurenin|02JW4J5R44|Benzenebutanoic acid, .alpha.,2-diamino-.gamma.-oxo-, (S)-|B Specifications & Purity 10mM in DMSO Biochemical and Physiological Mechanisms Endogenous AhR agonist. L-Tryptophan metabolite. Suppresses allogeneic T cell proliferation. Centrally active. Storage Temp Store at -80°C Shipped In Ice chest + Ice pads Product Description L-Kynurenine is a key intermediate in the breakdown pathway of tryptophan. L-Kynurenine is a substrate of kynureninase, KMO, and KAT associated with the suppression of antitumor immune responses. It has been shown to inhibit allogeneic T-cell proliferation and to increase malignant U87 glioma cell invasion into a collagen matrix.
Names and Identifiers IUPAC Name (2S)-2-amino-4-(2-aminophenyl)-4-oxobutanoic acid INCHI InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1 InChi Key YGPSJZOEDVAXAB-QMMMGPOBSA-N Canonical SMILES C1=CC=C(C(=C1)C(=O)CC(C(=O)O)N)N Isomeric SMILES C1=CC=C(C(=C1)C(=O)C[C@@H](C(=O)O)N)N RTECS CY9049700 PubChem CID 161166 Molecular Weight 208.22(as Anhydrous) Beilstein 14(4)1656 Reaxy-Rn 2942333
Chemical and Physical Properties Sensitivity air sensitive Refractive Index -33° (C=0.4,H2O) Specific Rotation[α] -33° (C=0.4,H2O) Melt Point(°C) 219 °C
Safety and Hazards(GHS) RTECS CY9049700 Reaxy-Rn 2942333 Merck Index 5328
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