L-Kynurenine is a key intermediate in the breakdown pathway of tryptophan. L-Kynurenine is a substrate of kynureninase, KMO, and KAT associated with the suppression of antitumor immune responses. It has been shown to inhibit allogeneic T-cell proliferation and to increase malignant U87 glioma cell invasion into a collagen matrix.
1.Wu Hao, Bao Yuling, Yan Tongtong, Huang Hui, Jiang Ping, Zhang Zhan, Li Lei, Wu Qian. (2023) PAH-induced metabolic changes related to inflammation in childhood asthma. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 30 (5):(13739-13754). [PMID:36136199][10.1007/s11356-022-23091-9]
2.Lu Geng, Zhou Jiawei, Yang Ting, Li Jin, Jiang Xinrui, Zhang Wenjun, Gu Shuangshuang, Wang Jun. (2022) Landscape of Metabolic Fingerprinting for Diagnosis and Risk Stratification of Sepsis. Frontiers in Immunology, 13 [PMID:35663956][10.3389/fimmu.2022.883628]
3.Zhenyang Gu, Wenlong Pei, Yonghua Shen, Lijuan Wang, Jun Zhu, Yi Zhang, Shengxian Fan, Qian Wu, Lei Li, Zhan Zhang. (2021) Akkermansia muciniphila and its outer protein Amuc_1100 regulates tryptophan metabolism in colitis. Food & Function, 12 (20):(10184-10195). [PMID:34532729][10.1039/D1FO02172A]
4.Yun Chen, Hui Chen, Ganggang Shi, Min Yang, Fuchun Zheng, Zhijie Zheng, Shuyao Zhang, Shilong Zhong. (2019) Ultra-performance liquid chromatography-tandem mass spectrometry quantitative profiling of tryptophan metabolites in human plasma and its application to clinical study. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1128 (121745). [PMID:31586884][10.1016/j.jchromb.2019.121745]
5.Ning Wang, Jie Zhang, Qiao Li, Hui Xu, Geng Chen, Zhiyong Li, Difa Liu, Xin Yang. (2019) Discovery of potent indoleamine 2,3-dioxygenase (IDO) inhibitor from alkaloids in Picrasma quassioides by virtual screening and in vitro evaluation. FITOTERAPIA, 133 (137). [PMID:30654128][10.1016/j.fitote.2019.01.005]
References
1.Wu Hao, Bao Yuling, Yan Tongtong, Huang Hui, Jiang Ping, Zhang Zhan, Li Lei, Wu Qian. (2023) PAH-induced metabolic changes related to inflammation in childhood asthma. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 30 (5):(13739-13754). [PMID:36136199][10.1007/s11356-022-23091-9]
2.Lu Geng, Zhou Jiawei, Yang Ting, Li Jin, Jiang Xinrui, Zhang Wenjun, Gu Shuangshuang, Wang Jun. (2022) Landscape of Metabolic Fingerprinting for Diagnosis and Risk Stratification of Sepsis. Frontiers in Immunology, 13 [PMID:35663956][10.3389/fimmu.2022.883628]
3.Zhenyang Gu, Wenlong Pei, Yonghua Shen, Lijuan Wang, Jun Zhu, Yi Zhang, Shengxian Fan, Qian Wu, Lei Li, Zhan Zhang. (2021) Akkermansia muciniphila and its outer protein Amuc_1100 regulates tryptophan metabolism in colitis. Food & Function, 12 (20):(10184-10195). [PMID:34532729][10.1039/D1FO02172A]
4.Yun Chen, Hui Chen, Ganggang Shi, Min Yang, Fuchun Zheng, Zhijie Zheng, Shuyao Zhang, Shilong Zhong. (2019) Ultra-performance liquid chromatography-tandem mass spectrometry quantitative profiling of tryptophan metabolites in human plasma and its application to clinical study. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1128 (121745). [PMID:31586884][10.1016/j.jchromb.2019.121745]
5.Ning Wang, Jie Zhang, Qiao Li, Hui Xu, Geng Chen, Zhiyong Li, Difa Liu, Xin Yang. (2019) Discovery of potent indoleamine 2,3-dioxygenase (IDO) inhibitor from alkaloids in Picrasma quassioides by virtual screening and in vitro evaluation. FITOTERAPIA, 133 (137). [PMID:30654128][10.1016/j.fitote.2019.01.005]
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