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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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S138616-25mg | 25mg | In stock | $18.90 | |
S138616-100mg | 100mg | In stock | $56.90 | |
S138616-500mg | 500mg | In stock | $252.90 |
Endogenous AhR agonist
Synonyms | L-kynurenine|2922-83-0|(S)-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid|Kynurenine, L-|3-Anthraniloyl-L-alanine|(2S)-2-amino-4-(2-aminophenyl)-4-oxobutanoic acid|CHEBI:16946|Kynurenin|02JW4J5R44|Benzenebutanoic acid, .alpha.,2-diamino-.gamma.-oxo-, (S)-|B |
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Specifications & Purity | ≥98%(T) |
Biochemical and Physiological Mechanisms | Endogenous AhR agonist. L-Tryptophan metabolite. Suppresses allogeneic T cell proliferation. Centrally active. |
Storage Temp | Store at -20°C,Argon charged |
Shipped In | Ice chest + Ice pads |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | L-Kynurenine is a key intermediate in the breakdown pathway of tryptophan. L-Kynurenine is a substrate of kynureninase, KMO, and KAT associated with the suppression of antitumor immune responses. It has been shown to inhibit allogeneic T-cell proliferation and to increase malignant U87 glioma cell invasion into a collagen matrix.
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Pubchem Sid | 488188330 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488188330 |
IUPAC Name | (2S)-2-amino-4-(2-aminophenyl)-4-oxobutanoic acid |
INCHI | InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1 |
InChi Key | YGPSJZOEDVAXAB-QMMMGPOBSA-N |
Canonical SMILES | C1=CC=C(C(=C1)C(=O)CC(C(=O)O)N)N |
Isomeric SMILES | C1=CC=C(C(=C1)C(=O)C[C@@H](C(=O)O)N)N |
RTECS | CY9049700 |
PubChem CID | 161166 |
Molecular Weight | 208.22(as Anhydrous) |
Beilstein | 14(4)1656 |
Reaxy-Rn | 2942333 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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B2215401 | Certificate of Analysis | Dec 21, 2023 | S138616 |
B2215620 | Certificate of Analysis | Dec 21, 2023 | S138616 |
A2205489 | Certificate of Analysis | Oct 08, 2023 | S138616 |
A2205485 | Certificate of Analysis | Oct 08, 2023 | S138616 |
E2413071 | Certificate of Analysis | Jul 08, 2023 | S138616 |
H2301931 | Certificate of Analysis | Jul 08, 2023 | S138616 |
H2301915 | Certificate of Analysis | Jul 08, 2023 | S138616 |
H2301914 | Certificate of Analysis | Jul 08, 2023 | S138616 |
C2314221 | Certificate of Analysis | Mar 08, 2023 | S138616 |
C2324222 | Certificate of Analysis | Mar 08, 2023 | S138616 |
C2314220 | Certificate of Analysis | Mar 08, 2023 | S138616 |
C2313922 | Certificate of Analysis | Mar 08, 2023 | S138616 |
A2304144 | Certificate of Analysis | Dec 02, 2022 | S138616 |
L2228025 | Certificate of Analysis | Dec 02, 2022 | S138616 |
L2228052 | Certificate of Analysis | Dec 02, 2022 | S138616 |
L2228056 | Certificate of Analysis | Dec 02, 2022 | S138616 |
L2228059 | Certificate of Analysis | Dec 02, 2022 | S138616 |
L2228063 | Certificate of Analysis | Dec 02, 2022 | S138616 |
I2002096 | Certificate of Analysis | Jul 11, 2022 | S138616 |
B2215402 | Certificate of Analysis | Dec 01, 2021 | S138616 |
Sensitivity | air sensitive |
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Refractive Index | -33° (C=0.4,H2O) |
Specific Rotation[α] | -33° (C=0.4,H2O) |
Melt Point(°C) | 219 °C |
RTECS | CY9049700 |
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Reaxy-Rn | 2942333 |
Merck Index | 5328 |
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