Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
L-Kynurenine is a key intermediate in the breakdown pathway of tryptophan. L-Kynurenine is a substrate of kynureninase, KMO, and KAT associated with the suppression of antitumor immune responses. It has been shown to inhibit allogeneic T-cell proliferation and to increase malignant U87 glioma cell invasion into a collagen matrix.
1.Wu Hao, Bao Yuling, Yan Tongtong, Huang Hui, Jiang Ping, Zhang Zhan, Li Lei, Wu Qian. (2023) PAH-induced metabolic changes related to inflammation in childhood asthma. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 30 (5):(13739-13754). [PMID:36136199][10.1007/s11356-022-23091-9]
2.Lu Geng, Zhou Jiawei, Yang Ting, Li Jin, Jiang Xinrui, Zhang Wenjun, Gu Shuangshuang, Wang Jun. (2022) Landscape of Metabolic Fingerprinting for Diagnosis and Risk Stratification of Sepsis. Frontiers in Immunology, 13 [PMID:35663956][10.3389/fimmu.2022.883628]
3.Zhenyang Gu, Wenlong Pei, Yonghua Shen, Lijuan Wang, Jun Zhu, Yi Zhang, Shengxian Fan, Qian Wu, Lei Li, Zhan Zhang. (2021) Akkermansia muciniphila and its outer protein Amuc_1100 regulates tryptophan metabolism in colitis. Food & Function, 12 (20):(10184-10195). [PMID:34532729][10.1039/D1FO02172A]
4.Yun Chen, Hui Chen, Ganggang Shi, Min Yang, Fuchun Zheng, Zhijie Zheng, Shuyao Zhang, Shilong Zhong. (2019) Ultra-performance liquid chromatography-tandem mass spectrometry quantitative profiling of tryptophan metabolites in human plasma and its application to clinical study. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1128 (121745). [PMID:31586884][10.1016/j.jchromb.2019.121745]
5.Ning Wang, Jie Zhang, Qiao Li, Hui Xu, Geng Chen, Zhiyong Li, Difa Liu, Xin Yang. (2019) Discovery of potent indoleamine 2,3-dioxygenase (IDO) inhibitor from alkaloids in Picrasma quassioides by virtual screening and in vitro evaluation. FITOTERAPIA, 133 (137). [PMID:30654128][10.1016/j.fitote.2019.01.005]
References
1.Wu Hao, Bao Yuling, Yan Tongtong, Huang Hui, Jiang Ping, Zhang Zhan, Li Lei, Wu Qian. (2023) PAH-induced metabolic changes related to inflammation in childhood asthma. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 30 (5):(13739-13754). [PMID:36136199][10.1007/s11356-022-23091-9]
2.Lu Geng, Zhou Jiawei, Yang Ting, Li Jin, Jiang Xinrui, Zhang Wenjun, Gu Shuangshuang, Wang Jun. (2022) Landscape of Metabolic Fingerprinting for Diagnosis and Risk Stratification of Sepsis. Frontiers in Immunology, 13 [PMID:35663956][10.3389/fimmu.2022.883628]
3.Zhenyang Gu, Wenlong Pei, Yonghua Shen, Lijuan Wang, Jun Zhu, Yi Zhang, Shengxian Fan, Qian Wu, Lei Li, Zhan Zhang. (2021) Akkermansia muciniphila and its outer protein Amuc_1100 regulates tryptophan metabolism in colitis. Food & Function, 12 (20):(10184-10195). [PMID:34532729][10.1039/D1FO02172A]
4.Yun Chen, Hui Chen, Ganggang Shi, Min Yang, Fuchun Zheng, Zhijie Zheng, Shuyao Zhang, Shilong Zhong. (2019) Ultra-performance liquid chromatography-tandem mass spectrometry quantitative profiling of tryptophan metabolites in human plasma and its application to clinical study. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1128 (121745). [PMID:31586884][10.1016/j.jchromb.2019.121745]
5.Ning Wang, Jie Zhang, Qiao Li, Hui Xu, Geng Chen, Zhiyong Li, Difa Liu, Xin Yang. (2019) Discovery of potent indoleamine 2,3-dioxygenase (IDO) inhibitor from alkaloids in Picrasma quassioides by virtual screening and in vitro evaluation. FITOTERAPIA, 133 (137). [PMID:30654128][10.1016/j.fitote.2019.01.005]
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