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L-Kynurenine sulfate salt - crystalline, high purity , CAS No.16055-80-4

crystalline

CAS#: 16055-80-4
Formula: C₁₀H₁₂N₂O₃ · H₂SO₄
Molecular Weight: 306.29
MDL number: MFCD00039104
PubChem CID: 161165

Item Number

L477448

Grouped product items
SKU	Size	Availability	Price
L477448-500mg	500mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$546.90
L477448-1g	1g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$910.90
L477448-5g	5g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$4,095.90

Basic Description

Synonyms	L-KYNURENINE SULFATE\|Kynurenine sulfate\|16055-80-4\|L-Kynurenine sulfate salt\|13535-93-8\|L-Kynurenine (sulfate)\|O9Y8MI1F7U\|(S)-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid compound with sulfuric acid (1:1)\|16055-30-4\|17268-44-9\|B-ANTHRAANILOYL-L-ALANINE SU
Specifications & Purity	crystalline
Biochemical and Physiological Mechanisms	L-Kynurenine is a key intermediate in the breakdown of L-tryptophan and the formation of nicotinamide adenine dinucleotide (NAD+) via the kynurenine pathway. L-kynurenine is involved in a variety of neurological processes and diseases. L-kynurenine is a
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	Description L-Kynurenine sulfate salt has been used as a substrate to study the enzyme activity of kynurenine aminotransferase. It has also been used in the synthesis of Kyn adducts of certain amino acids .

Associated Targets

GMNN Tbio Geminin 0 Activities

Discover Target: GMNN

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTH1R Tclin Parathyroid hormone/parathyroid hormone-related peptide receptor 0 Activities

Discover Target: PTH1R

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KDM4A Tchem Lysine-specific demethylase 4A 0 Activities

Discover Target: KDM4A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(2S)-2-amino-4-(2-aminophenyl)-4-oxobutanoic acid;sulfuric acid
INCHI	InChI=1S/C10H12N2O3.H2O4S/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15;1-5(2,3)4/h1-4,8H,5,11-12H2,(H,14,15);(H2,1,2,3,4)/t8-;/m0./s1
InChi Key	KAXRWMOLNJZCEW-QRPNPIFTSA-N
Canonical SMILES	C1=CC=C(C(=C1)C(=O)CC(C(=O)O)N)N.OS(=O)(=O)O
Isomeric SMILES	C1=CC=C(C(=C1)C(=O)C[C@@H](C(=O)O)N)N.OS(=O)(=O)O
PubChem CID	161165
Molecular Weight	306.29

References

1. Song Guo,L Vecsei,Messoud Ashina. (2011-05-20) The L-kynurenine signalling pathway in trigeminal pain processing: a potential therapeutic target in migraine?. Cephalalgia : an international journal of headache, 31 ((9)): (1029-1038). [PMID:21593189]
2. Joyce A Ibana,Robert J Belland,Arnold H Zea,Danny J Schust,Takeshi Nagamatsu,Yasser M AbdelRahman,David J Tate,Wandy L Beatty,Ashok A Aiyar,Alison J Quayle. (2011-09-14) Inhibition of indoleamine 2,3-dioxygenase activity by levo-1-methyl tryptophan blocks gamma interferon-induced Chlamydia trachomatis persistence in human epithelial cells.. Infection and immunity, 79 ((11)): (4425-4437). [PMID:21911470]
3. Claire A Knoten,L Lynn Hudson,James P Coleman,John M Farrow,Everett C Pesci. (2011-10-04) KynR, a Lrp/AsnC-type transcriptional regulator, directly controls the kynurenine pathway in Pseudomonas aeruginosa.. Journal of bacteriology, 193 ((23)): (6567-6575). [PMID:21965577]
4. K Nagy,I Plangár,B Tuka,L Gellért,D Varga,I Demeter,T Farkas,Zs Kis,M Marosi,D Zádori,P Klivényi,F Fülöp,I Szatmári,L Vécsei,J Toldi. (2011-11-15) Synthesis and biological effects of some kynurenic acid analogs.. Bioorganic & medicinal chemistry, 19 ((24)): (7590-7596). [PMID:22079867]
5. Klas Linderholm,Susan Powell,Elin Olsson,Maria Holtze,Ralph Snodgrass,Sophie Erhardt. (2010-01-01) Role of the NMDA-receptor in Prepulse Inhibition in the Rat.. International journal of tryptophan research : IJTR, 3 (1-12). [PMID:22084584]
6. Airi Sekine,Misaki Okamoto,Yuka Kanatani,Mitsue Sano,Katsumi Shibata,Tsutomu Fukuwatari. (2015-02-13) Amino acids inhibit kynurenic acid formation via suppression of kynurenine uptake or kynurenic acid synthesis in rat brain in vitro.. SpringerPlus, 4 (48-48). [PMID:25674503]
7. Naoko Arashida,Rumi Nishimoto,Masashi Harada,Kazutaka Shimbo,Naoyuki Yamada. (2017-01-14) Highly sensitive quantification for human plasma-targeted metabolomics using an amine derivatization reagent.. Analytica chimica acta, 954 (77-87). [PMID:28081817]
8. Qian Wang,Guochen Qin,Min Cao,Rong Chen,Yuming He,Liyuan Yang,Zhejun Zeng,Yongqiang Yu,Yangtao Gu,Weiman Xing,W Andy Tao,Tongda Xu. (2020-02-06) A phosphorylation-based switch controls TAA1-mediated auxin biosynthesis in plants.. Nature communications, 11 ((1)): (679-679). [PMID:32015349]
9. Linnéa Asp,Anne-Sofie Johansson,Amandeep Mann,Björn Owe-Larsson,Ewa M Urbanska,Tomasz Kocki,Magdalena Kegel,Göran Engberg,Gabriella Bs Lundkvist,Håkan Karlsson. (2011-10-11) Effects of pro-inflammatory cytokines on expression of kynurenine pathway enzymes in human dermal fibroblasts.. Journal of inflammation (London, England), 8 (25-25). [PMID:21982155]
10. Jing Shi,Chen Chen,Rui Ju,Qingzhu Wang,Juan Li,Lei Guo,Caiying Ye,Dechang Zhang. (2019-09-13) Carboxyamidotriazole combined with IDO1-Kyn-AhR pathway inhibitors profoundly enhances cancer immunotherapy.. Journal for immunotherapy of cancer, 7 ((1)): (246-246). [PMID:31511064]

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