L-Leucine - ≥99%, high purity , CAS No.61-90-5

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Item Number
L104898
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Chemical Biology Peptide chemistry

Basic Description

Synonyms(S)-2-Amino-4-methylpentanoic acid | NSC-46709 | .alpha.-Amino-.gamma.-methylvaleric acid | LEUCINE [HSDB] | 2-Amino-4-methylvaleric acid (L) | L-Leu | GMW67QNF9C | IS_LEUCINE-5,5,5-D3 | MFCD00002617 | (S)-2-Amino-4-methylpentanoate | L-LEUCINE [USP-RS] |
Specifications & PurityMoligand™, ≥99%
Biochemical and Physiological Mechanisms亮氨酸是一种非生糖必需氨基酸。它是一种支链氨基酸,是蛋白质的结构组分。亮氨酸对胰岛素的释放可产生积极影响,从而消除血液中的毒性糖。亮氨酸的降解会导致酮体的形成。
Storage TempDesiccated
Shipped InNormal
GradeMoligand™

Associated Targets(Human)

CYP1A2 Tchem Cytochrome P450 1A2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CYP2D6 Tclin Cytochrome P450 2D6 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CYP2C19 Tchem Cytochrome P450 2C19 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CYP3A4 Tclin Cytochrome P450 3A4 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CYP2C9 Tchem Cytochrome P450 2C9 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SLC36A1 Tchem Proton-coupled amino acid transporter 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
HDAC6 Tclin Histone deacetylase 6 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PLAA Tchem Phospholipase A-2-activating protein (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SLC16A2 Tbio Monocarboxylate transporter 8 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SLC16A10 Tbio Monocarboxylate transporter 10 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SLC7A5 Tchem Large neutral amino acids transporter small subunit 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ALPI Tchem Intestinal-type alkaline phosphatase (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ALPL Tchem Alkaline phosphatase, tissue-nonspecific isozyme (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Homo sapiens (32628 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC7A5 Tchem L-type amino acid transporter 1 (388 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALPL Tchem Alkaline phosphatase, tissue-nonspecific isozyme (1551 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Liver microsomes (16955 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PLAA Tchem Phospholipase A-2-activating protein (44 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC36A1 Tchem Proton-coupled amino acid transporter 1 (102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC16A10 SLC16A10 protein (28 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Iap Intestinal alkaline phosphatase (419 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pseudomonas aeruginosa (123386 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Klebsiella pneumoniae (43867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus epidermidis (22802 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Escherichia coli (133304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Bacillus subtilis (32866 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Aspergillus fumigatus (16427 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cryptococcus neoformans (21258 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Candida albicans (78123 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Candida parapsilosis (8521 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium berghei (192651 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Sporothrix schenckii (1580 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDCK (10148 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RAW264.7 (28094 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NIH3T3 (5395 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trichophyton mentagrophytes (4846 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Slc16a10 Monocarboxylate transporter 10 (73 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC16A2 Monocarboxylate transporter 8 (28 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Lipopolysaccharide (LPS) (376 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Slc7a5 Large neutral amino acids transporter small subunit 1 (4 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

Pubchem Sid488180007
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488180007
IUPAC Name (2S)-2-amino-4-methylpentanoic acid
INCHI InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1
InChi Key ROHFNLRQFUQHCH-YFKPBYRVSA-N
Canonical SMILES CC(C)CC(C(=O)O)N
Isomeric SMILES CC(C)C[C@@H](C(=O)O)N
WGK Germany 1
PubChem CID 6106
Molecular Weight 131.17
Beilstein 4437

Certificates

Certificate of Analysis(COA)

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33 results found

Lot NumberCertificate TypeDateItem
G2429104Certificate of AnalysisJul 05, 2024 L104898
G2429110Certificate of AnalysisJul 05, 2024 L104898
G2429109Certificate of AnalysisJul 05, 2024 L104898
G2429107Certificate of AnalysisJul 05, 2024 L104898
G2429106Certificate of AnalysisJul 05, 2024 L104898
E2411211Certificate of AnalysisMay 24, 2024 L104898
E2411213Certificate of AnalysisMay 24, 2024 L104898
E2411212Certificate of AnalysisMay 24, 2024 L104898
E2411214Certificate of AnalysisMay 24, 2024 L104898
E2411215Certificate of AnalysisMay 24, 2024 L104898
F2425209Certificate of AnalysisMay 17, 2024 L104898
F2417232Certificate of AnalysisMay 17, 2024 L104898
J2226560Certificate of AnalysisJul 21, 2022 L104898
J2226563Certificate of AnalysisJul 21, 2022 L104898
J2226564Certificate of AnalysisJul 21, 2022 L104898
J2226603Certificate of AnalysisJul 21, 2022 L104898
A2410070Certificate of AnalysisJul 21, 2022 L104898
J2226604Certificate of AnalysisJul 21, 2022 L104898
B2321929Certificate of AnalysisJul 21, 2022 L104898
B2321928Certificate of AnalysisJul 21, 2022 L104898
B2321895Certificate of AnalysisJul 21, 2022 L104898
B2321894Certificate of AnalysisJul 21, 2022 L104898
B2321893Certificate of AnalysisJul 21, 2022 L104898
B23211082Certificate of AnalysisJul 21, 2022 L104898
B23211077Certificate of AnalysisJul 21, 2022 L104898
B23211033Certificate of AnalysisJul 21, 2022 L104898
A2416064Certificate of AnalysisJul 21, 2022 L104898
A2410079Certificate of AnalysisJul 21, 2022 L104898
C2210528Certificate of AnalysisDec 16, 2021 L104898
C2210523Certificate of AnalysisDec 16, 2021 L104898
C2210522Certificate of AnalysisDec 16, 2021 L104898
C2210518Certificate of AnalysisDec 16, 2021 L104898
C2210407Certificate of AnalysisDec 16, 2021 L104898

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Chemical and Physical Properties

SolubilitySoluble in water, alcohol, acetic acid and hydrochloric acid. Insoluble in ether.
SensitivityLight sensitive;Moisture sensitive
Specific Rotation[α][α]20/D +15.5±0.5°, c = 5% in 5 M HCl
Boil Point(°C)122-134 °C
Melt Point(°C)>300°C

Safety and Hazards(GHS)

WGK Germany 1
Merck Index 5451

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