L-Leucine - from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 98.5-101.0%, high purity , CAS No.61-90-5

72 Citations
  • CAS#:  61-90-5
  • Formula:   C6H13NO2
  • Molecular Weight:  131.17
  • Beilstein Registry Number:   4437
  • PubChem CID:   6106
Item Number
L433130
Grouped product items
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L433130-25g
25g
In stock
$47.90
L433130-100g
100g
In stock
$153.90
L433130-500g
500g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$599.90

Basic Description

Synonyms(S)-2-Amino-4-methylpentanoic acid | NSC-46709 | .alpha.-Amino-.gamma.-methylvaleric acid | LEUCINE [HSDB] | 2-Amino-4-methylvaleric acid (L) | L-Leu | GMW67QNF9C | IS_LEUCINE-5,5,5-D3 | MFCD00002617 | (S)-2-Amino-4-methylpentanoate | L-LEUCINE [USP-RS] |
Specifications & PurityMoligand™, Animal Free, USP, JP, Ph.Eur., for cell culture, ≥98.5%
Biochemical and Physiological MechanismsLeucine is a non-glucogenic, essential amino acid. It is a branched-chain amino acid that is a structural component of proteins. Leucine positively influences insulin release to eliminate toxic sugars out of the blood. The degradation of leucine leads to
Storage TempProtected from light
Shipped InNormal
GradeAnimal Free, for cell culture, JP, Moligand™, Ph.Eur., USP
Product Description

Application

L-leucine has been used as a hypertrophic agent to monitor its effects on myotubes. It has also been used as a component of PMG media for culturing yeast.

Associated Targets(Human)

CYP1A2 Tchem Cytochrome P450 1A2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CYP2D6 Tclin Cytochrome P450 2D6 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CYP2C19 Tchem Cytochrome P450 2C19 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CYP3A4 Tclin Cytochrome P450 3A4 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CYP2C9 Tchem Cytochrome P450 2C9 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SLC36A1 Tchem Proton-coupled amino acid transporter 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
HDAC6 Tclin Histone deacetylase 6 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PLAA Tchem Phospholipase A-2-activating protein (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SLC16A2 Tbio Monocarboxylate transporter 8 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SLC16A10 Tbio Monocarboxylate transporter 10 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SLC7A5 Tchem Large neutral amino acids transporter small subunit 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ALPI Tchem Intestinal-type alkaline phosphatase (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ALPL Tchem Alkaline phosphatase, tissue-nonspecific isozyme (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Homo sapiens (32628 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC7A5 Tchem L-type amino acid transporter 1 (388 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALPL Tchem Alkaline phosphatase, tissue-nonspecific isozyme (1551 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Liver microsomes (16955 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PLAA Tchem Phospholipase A-2-activating protein (44 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC36A1 Tchem Proton-coupled amino acid transporter 1 (102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC16A10 SLC16A10 protein (28 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Iap Intestinal alkaline phosphatase (419 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pseudomonas aeruginosa (123386 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Klebsiella pneumoniae (43867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus epidermidis (22802 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Escherichia coli (133304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Bacillus subtilis (32866 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Aspergillus fumigatus (16427 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cryptococcus neoformans (21258 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Candida albicans (78123 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Candida parapsilosis (8521 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium berghei (192651 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Sporothrix schenckii (1580 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDCK (10148 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RAW264.7 (28094 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NIH3T3 (5395 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trichophyton mentagrophytes (4846 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Slc16a10 Monocarboxylate transporter 10 (73 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC16A2 Monocarboxylate transporter 8 (28 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Lipopolysaccharide (LPS) (376 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Slc7a5 Large neutral amino acids transporter small subunit 1 (4 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name (2S)-2-amino-4-methylpentanoic acid
INCHI InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1
InChi Key ROHFNLRQFUQHCH-YFKPBYRVSA-N
Canonical SMILES CC(C)CC(C(=O)O)N
Isomeric SMILES CC(C)C[C@@H](C(=O)O)N
WGK Germany 1
PubChem CID 6106
Molecular Weight 131.17
Beilstein 4437

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

6 results found

Lot NumberCertificate TypeDateItem
E2326855Certificate of AnalysisMay 12, 2023 L433130
E2326859Certificate of AnalysisMay 12, 2023 L433130
E2326860Certificate of AnalysisMay 12, 2023 L433130
E2326861Certificate of AnalysisMay 12, 2023 L433130
E2326862Certificate of AnalysisMay 12, 2023 L433130
E2327315Certificate of AnalysisMay 12, 2023 L433130

Chemical and Physical Properties

Solubility1 M HCl: 50mg/mL
SensitivitySensitive to light; Sensitivity to humidity
Specific Rotation[α][α]20/D +15.5±0.5°, c = 5% in 5 M HCl
Boil Point(°C)122-134 °C
Melt Point(°C)>300°C

Safety and Hazards(GHS)

WGK Germany 1
Merck Index 5451

Related Documents

Citations of This Product

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4. Yan Li, Zhenyuan Yin, Hongfeng Lu, Chenlu Xu, Xuejian Liu, Hailin Huang, Daoyi Chen, Praveen Linga.  (2023)  Evaluation of amino acid L-leucine as a kinetic promoter for CO2 sequestration as hydrate: A kinetic and morphological study.  Journal of Environmental Chemical Engineering,  11  (22): (111363).  [PMID:9298994]
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Solution Calculators