Basic Description

Synonyms	H-Met-OH \| (35S)Methionine \| carbon-11 methionine \| L-2-Amino-4methylthiobutyric acid \| METHIONINE [II] \| L-Methionin \| L-Methionine-34S \| L-Methioninum \| 1pg2 \| Methionine [USAN:USP:INN:BAN] \| MFCD00063097 \| (2S)-2-amino-4-(methylsulfanyl)butanoic acid \|
Specifications & Purity	Moligand™, ≥99%
Biochemical and Physiological Mechanisms	Methionine is an essential amino acid which acts a precursor for transmethylation and transsulphuration. In proteins, L-methionine is the biologically active form.The adenosylation of methionine results in the formation of S-adenosyl-L-methionine (SAM), w
Storage Temp	Store at 2-8°C,Protected from light,Argon charged
Shipped In	Wet ice
Grade	Moligand™
Product Description	L-Methionine is an essential amino acid for human development, hepatoprotectant, acetominophen poisoning antidote, and urinary acidifier. An essential amino acid Application: L-Methionine is used as an essential amino acid for human development and therapeutically acts as an antidote for acetaminophen poisoning. It serves as a chelating agent for heavy metals, as a flavoring agent and nutritional supplement for foods. It acts as a feed additive, vegetable oil enrichment and as a single cell protein. In addition to this, it is used as a hepatoprotectant and also acts as a lipotropic agent and prevents excess fat buildup in the liver.

Associated Targets(Human)

F2 Tclin Thrombin (11687 Activities)

Discover Target: F2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ESR1 Tclin Estrogen receptor alpha (17718 Activities)

Discover Target: ESR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PGR Tclin Progesterone receptor (8562 Activities)

Discover Target: PGR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)

Discover Target: CHRM2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)

Discover Target: HTR1A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)

Discover Target: ADRA2A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AR Tclin Androgen Receptor (11781 Activities)

Discover Target: AR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)

Discover Target: CHRM1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GABRA1 Tclin GABA receptor alpha-1 subunit (399 Activities)

Discover Target: GABRA1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MAOA Tclin Monoamine oxidase A (11911 Activities)

Discover Target: MAOA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DRD1 Tclin Dopamine D1 receptor (9720 Activities)

Discover Target: DRD1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ACHE Tclin Acetylcholinesterase (18204 Activities)

Discover Target: ACHE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)

Discover Target: PTGS1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC6A2 Tclin Norepinephrine transporter (10102 Activities)

Discover Target: SLC6A2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ADORA1 Tclin Adenosine A1 receptor (17603 Activities)

Discover Target: ADORA1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC6A4 Tclin Serotonin transporter (12625 Activities)

Discover Target: SLC6A4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)

Discover Target: ADRA1A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

OPRM1 Tclin Mu opioid receptor (19785 Activities)

Discover Target: OPRM1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DRD3 Tclin Dopamine D3 receptor (14368 Activities)

Discover Target: DRD3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC6A3 Tclin Dopamine transporter (10535 Activities)

Discover Target: SLC6A3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PDE3A Tclin Phosphodiesterase 3A (3309 Activities)

Discover Target: PDE3A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 Activities)

Discover Target: HTR2B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TBXA2R Tclin Thromboxane A2 receptor (5717 Activities)

Discover Target: TBXA2R

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PDE4A Tclin Phosphodiesterase 4A (1943 Activities)

Discover Target: PDE4A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HRH3 Tclin Histamine H3 receptor (10389 Activities)

Discover Target: HRH3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

FASN Tchem Fatty acid synthase (3390 Activities)

Discover Target: FASN

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Homo sapiens (32628 Activities)

Discover Target:

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC7A5 Tchem L-type amino acid transporter 1 (388 Activities)

Discover Target: SLC7A5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Mat1a S-adenosylmethionine synthetase alpha and beta forms (31 Activities)

Discover Target: Mat1a

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mat2a S-adenosylmethionine synthetase gamma form (83 Activities)

Discover Target: Mat2a

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Pkm Pyruvate kinase isozymes M1/M2 (66 Activities)

Discover Target: Pkm

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Ggt1 Gamma-glutamyltranspeptidase 1 (36 Activities)

Discover Target: Ggt1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Pyricularia grisea (1253 Activities)

Discover Target:

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Oryza sativa (2923 Activities)

Discover Target:

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

luxS S-ribosylhomocysteine lyase (12 Activities)

Discover Target: luxS

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Slc16a10 Monocarboxylate transporter 10 (73 Activities)

Discover Target: Slc16a10

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mat1a S-adenosylmethionine synthetase (MAT 1 and MAT 2) (155 Activities)

Discover Target: Mat1a

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Slc1a5 Amino acid transporter (271 Activities)

Discover Target: Slc1a5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Discover Target:

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

Pubchem Sid	488180013
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488180013
IUPAC Name	(2S)-2-amino-4-methylsulfanylbutanoic acid
INCHI	InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1
InChi Key	FFEARJCKVFRZRR-BYPYZUCNSA-N
Canonical SMILES	CSCC[C@H](N)C(O)=O
Isomeric SMILES	CSCC[C@@H](C(=O)O)N
WGK Germany	1
RTECS	PD0457000
Molecular Weight	149.21
Beilstein	1722294
Reaxy-Rn	1722294

Database links

PubChem SID	488180013

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

30 results found

Lot Number	Certificate Type	Date	Item
E2420305	Certificate of Analysis	Apr 19, 2024	M101130
E2420306	Certificate of Analysis	Apr 19, 2024	M101130
E2420307	Certificate of Analysis	Apr 19, 2024	M101130
D2411296	Certificate of Analysis	Apr 17, 2024	M101130
D2411297	Certificate of Analysis	Apr 17, 2024	M101130
D2411298	Certificate of Analysis	Apr 17, 2024	M101130
J2331554	Certificate of Analysis	Oct 18, 2023	M101130
J2331553	Certificate of Analysis	Oct 18, 2023	M101130
J2331552	Certificate of Analysis	Oct 18, 2023	M101130
J2331551	Certificate of Analysis	Oct 18, 2023	M101130
D2409045	Certificate of Analysis	Oct 18, 2023	M101130
F2310317	Certificate of Analysis	Jul 04, 2023	M101130
F2310318	Certificate of Analysis	Jul 04, 2023	M101130
F2310314	Certificate of Analysis	Jul 04, 2023	M101130
G2315296	Certificate of Analysis	Jun 29, 2023	M101130
G2315300	Certificate of Analysis	Jun 29, 2023	M101130
G2315924	Certificate of Analysis	Jun 29, 2023	M101130
G2315931	Certificate of Analysis	Jun 29, 2023	M101130
G2315932	Certificate of Analysis	Jun 29, 2023	M101130
D2419030	Certificate of Analysis	Dec 08, 2022	M101130
B2309423	Certificate of Analysis	Dec 08, 2022	M101130
B2309463	Certificate of Analysis	Dec 08, 2022	M101130
B2309460	Certificate of Analysis	Dec 08, 2022	M101130
B2309458	Certificate of Analysis	Dec 08, 2022	M101130
B2309455	Certificate of Analysis	Dec 08, 2022	M101130
B2309430	Certificate of Analysis	Dec 08, 2022	M101130
H2217415	Certificate of Analysis	Jul 04, 2022	M101130
H2217416	Certificate of Analysis	Jul 04, 2022	M101130
H2217438	Certificate of Analysis	Jul 04, 2022	M101130
H2217440	Certificate of Analysis	Jul 04, 2022	M101130

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Chemical and Physical Properties

Solubility	Soluble in 1M HCl (50 mg/ml), and water (56.6 mg/ml at 25 °C). Insoluble in ethanol, acetone, and ether.
Sensitivity	Light & Air sensitive.
Specific Rotation[α]	24° (C=8,HCl (1+1))
Melt Point(°C)	280-282°C

Safety and Hazards(GHS)

Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
WGK Germany	1
RTECS	PD0457000
Reaxy-Rn	1722294
Merck Index	5975

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Citations of This Product

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2. Ningxiang Yu, Zeyi Wu, Yijue Wang, Abel Wend-Soo Zongo, Xiaohua Nie, Yuanchao Lu, Qin Ye, Xianghe Meng. (2024) Formation of adducts during digestion triggered dietary protein for alleviating cytotoxicity of 2-tert-butyl-1,4-benzoquinone. FOOD AND CHEMICAL TOXICOLOGY, 183 (25): (114200). [PMID:38029872]
3. Zhiyang Xu, Yinzhou Yan, Xingyuan Wang, Xiaolei Wang, Zhixiang Zhou, Xi Yang, Tianrui Zhai. (2023) Determination of Enantiomeric Excess by Optofluidic Microlaser near Exceptional Point. Advanced Science, (2308362). [PMID:38072636]
4. Zhen Lin, Chuangui Cai, Wei Chen, Qian Deng, Jialin Yang, Kaiyuan Huang, Haohua Deng, Xinhua Lin, Wei Chen, Wensong Yao. (2024) Micelle-mediated chemiluminescence of 6-aza-2-thiothymine-protected gold nanoclusters for carbazochrome sodium sulfonate detection. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 308 (123738). [PMID:38086230]
5. Huan Wang, Wencheng Mu, Siying Wang, Lin Shi, Tianfeng Ma, Yongchang Lu. (2024) Facile synthesis of NS-doped carbon dots as sensitive “ON-OFF-ON” fluorescent sensor for Cu2+ and GSH detection. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 305 (123460). [PMID:37778177]
6. Wenjing Wang, Yumin He, Lei Deng, Hui Wang, Xiaoying Liu, Qing-wen Gui, Zhong Cao, Zemeng Feng, Benhai Xiong, Yulong Yin. (2023) Peptide aptamer-based polyaniline-modified amperometric biosensor for L-lysine detection in real serum samples. MEASUREMENT, 221 (113468). [PMID:]
7. Jing Hu, Effiong Kokoette, Caicai Xu, Shitao Huang, Tao Tang, Yiyi Zhang, Muyuan Liu, Yuzhou Huang, Shumiao Yu, Jie Zhu, Marianne Holmer, Xi Xiao. (2023) Natural Algaecide Sphingosines Identified in Hybrid Straw Decomposition Driven by White-Rot Fungi. Advanced Science, 10 (25): (2300569). [PMID:37400420]
8. Lei Jiang, Lin Yuan, Shan Gao, Yingying Xiang, Fei Song, Wensi Ma, Jing Wan, Xiuling Ji, Yujiao Tu. (2023) Facile hydrothermal synthesis of N-doped fluorescent carbon dots for selective detection of insecticide parathion. Analytical Methods, 15 (19): (2376-2381). [PMID:37132329]
9. Jiayin Du, Fengfeng Xie, Chunlan Liu, Baian Ji, Weili Wei, Min Wang, Zhining Xia. (2023) Chiral zinc oxide functionalized quartz crystal microbalance sensor for enantioselective recognition of amino acids. TALANTA, 259 (124496). [PMID:37031543]
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24. Ming Nie, Lu Wang, Shengmin Lu, Yangguang Wang, Meiyu Zheng, Zhongxiang Fang. (2022) Protective effect of amino acids on the stability of bayberry anthocyanins and the interaction mechanism between l-methionine and cyanidin-3-O-glycoside. FOOD CHEMISTRY, 396 (133689). [PMID:35849982]
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SKU	Size	Availability	Price
M101130-25g	25g	In stock	$19.90
M101130-100g	100g	In stock	$45.90
M101130-500g	500g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$142.90

L-Methionine - 99%, high purity , CAS No.63-68-3

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References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator