Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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N109573-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $39.90 | |
N109573-250mg | 250mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $85.90 | |
N109573-500mg | 500mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $166.90 | |
N109573-1g | 1g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $264.90 | |
N109573-5g | 5g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $1,188.90 |
Synonyms | (-)-Noradrec | Nor adrenalin | NOREPINEPHRINE [INN] | Sympathin E | NORADRENALINE [JAN] | NOREPINEPHRINE (USP IMPURITY) | Norepinephrine [INN:BAN:JAN] | A56046 | Benzyl alcohol, alpha-(aminomethyl)-3,4-dihydroxy-, (-)- | Levarterenolo | noradrAnaline | No |
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Specifications & Purity | Moligand™, ≥98% |
Storage Temp | Store at 2-8°C,Protected from light,Argon charged |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | AGONIST |
Mechanism of action | Agonist of α 1A-adrenoceptor;Agonist of α 1B-adrenoceptor;Agonist of α 1D-adrenoceptor;Agonist of α 2A-adrenoceptor;Agonist of α 2B-adrenoceptor;Agonist of α 2C-adrenoceptor;Agonist of β 1-adrenoceptor;Agonist of β 2-adrenoceptor;Agonist of β 3-adrenocept |
Product Description | Norepinephrine (Levophed) is an alkaloidal natural product, a neurotransmitter, an adrenergic receptor (AR) agonist, with activating activity on α1, α2, and β1 ARs. Norepinephrine has been used as a vasoactive agent in the treatment of antishock. |
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IUPAC Name | 4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol |
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INCHI | InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/t8-/m0/s1 |
InChi Key | SFLSHLFXELFNJZ-QMMMGPOBSA-N |
Canonical SMILES | C1=CC(=C(C=C1C(CN)O)O)O |
Isomeric SMILES | C1=CC(=C(C=C1[C@H](CN)O)O)O |
WGK Germany | 3 |
RTECS | DN5950000 |
PubChem CID | 439260 |
UN Number | 2811 |
Molecular Weight | 169.18 |
Beilstein | 2804840 |
PubChem CID | 439260 |
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ChEMBL Ligand | CHEMBL1437 |
BindingDB Ligand | 50030618 |
DrugBank Ligand | DB00368 |
CAS Registry No. | 51-41-2 |
Wikipedia | Norepinephrine |
RCSB PDB Ligand | LNR, LT4 |
PEP | noradrenaline |
DrugCentral Ligand | 1960 |
GPCRdb Ligand | (-)-noradrenaline |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
C2429656 | Certificate of Analysis | Mar 09, 2024 | N109573 |
C2429657 | Certificate of Analysis | Mar 09, 2024 | N109573 |
E2415071 | Certificate of Analysis | Sep 01, 2022 | N109573 |
K2229798 | Certificate of Analysis | Sep 01, 2022 | N109573 |
K2229799 | Certificate of Analysis | Sep 01, 2022 | N109573 |
C2411047 | Certificate of Analysis | May 28, 2022 | N109573 |
F2222435 | Certificate of Analysis | May 28, 2022 | N109573 |
J2317060 | Certificate of Analysis | May 28, 2022 | N109573 |
Solubility | 0.5 M HCl (50 mg/ml) |
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Sensitivity | Air & Light Sensitive |
Melt Point(°C) | 100-106°C |
Pictogram(s) | GHS06 |
---|---|
Signal | Danger |
Hazard Statements | H300:Fatal if swallowed H310:Fatal in contact with skin H330:Fatal if inhaled |
Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P284:[In case of inadequate ventilation] Wear respiratory protection. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P330:Rinse mouth. P262:Do not get in eyes, on skin, or on clothing. P320:Specific treatment is urgent (see ... on this label). P361+P364:Take off immediately all contaminated clothing and wash it before reuse. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P316:Get emergency medical help immediately. |
WGK Germany | 3 |
RTECS | DN5950000 |
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1. Jin Yuan Zhang, Ying Zhang, Yu Zou, Ze Li Bo Xu, Bo Zhang, Wang Ren. (2024) Physicochemically modulated fluorescence-scattering ratiometric sensor for selective and visual detection of levodopa. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 308 (123746). [PMID:38091648] |
2. Kai Hu, Tiantian Pang, Cheng Yang, Pengzhao Han, Lixin Li, Pan Wang, Zhenqiang Zhang, Wenjie Zhao, Shusheng Zhang. (2023) Simultaneous extraction of hydroxylated polycyclic aromatic hydrocarbons and catecholamines with magnetic boronic acid hypercrosslinked polymers. JOURNAL OF CHROMATOGRAPHY A, 1712 (464491). [PMID:37931428] |
3. Qiang Chen, Lili Zheng, Xiaoqin Deng, Menghan Zhang, Wendi Han, Zhengjun Huang, Chenfang Miao, Shaohuang Weng. (2023) A fluorescence biosensor for tyrosinase activity analysis based on silicon-doped carbon quantum dots. CHEMICAL & PHARMACEUTICAL BULLETIN, (4): [PMID:37704432] |
4. Wenting Lin, Kan Li, Yingjun Qin, Xing Han, Xiaohui Chen, Yuan Ren. (2023) Flunitrazepam induces neurotoxicity in zebrafish through microbiota-gut-brain axis. SCIENCE OF THE TOTAL ENVIRONMENT, 901 (165974). [PMID:37532048] |
5. Huang Liyuan, Su Ruobing, Xi Fengna. (2023) Sensitive detection of noradrenaline in human whole blood based on Au nanoparticles embedded vertically-ordered silica nanochannels modified pre-activated glassy carbon electrodes. Frontiers in Chemistry, 11 [PMID:36874060] |
6. Xin Huang, Rui Wang, Yikai Wang, Changbao Chen, Shuying Liu. (2023) Investigation on property differences of ginseng and American ginseng by spatial metabolomics of neurochemicals with desorption electrospray ionization mass spectrometry imaging. JOURNAL OF ETHNOPHARMACOLOGY, 303 (116006). [PMID:36516905] |
7. Shanshan Zhan, Caihong Xu, Jiandan Chen, Qi Xiao, Zhenzeng Zhou, Zhiyuan Xing, Chunchuan Gu, Zhengzhi Yin, Hongying Liu. (2023) A novel epinephrine biosensor based on gold nanoparticles coordinated polydopamine-functionalized acupuncture needle microelectrode. ELECTROCHIMICA ACTA, 437 (141468). [PMID:] |
8. Bin Liu, Chunmiao Bo, Yan Li, Xiaohua Ma, Bolin Gong, Shengwei Guo. (2022) Preparation of reversed-phase/boronate affinity mixed-mode restricted access materials with zwitterionic polymer outer layers and its extraction properties. JOURNAL OF CHROMATOGRAPHY A, 1679 (463398). [PMID:35964461] |
9. Biying Jiang, Baolong Cao, Zhichun Zhou, Zejiao Li, Can Lv, Jiannan Zhang, Heyuan Zhang, Yajun Wang, Juan Li. (2022) Characterization of Chicken α2A-Adrenoceptor: Molecular Cloning, Functional Analysis, and Its Involvement in Ovarian Follicular Development. Genes, 13 (7): (1113). [PMID:35885896] |
10. Zhu Anni, Wang Tiansheng, Jiang Yuning, Hu Sen, Tang Wanxin, Liu Xinling, Guo Xiaoyu, Ying Ye, Wu Yiping, Wen Ying, Yang Haifeng. (2022) SERS determination of dopamine using metal–organic frameworks decorated with Ag/Au noble metal nanoparticle composite after azo derivatization with p-aminothiophenol. MICROCHIMICA ACTA, 189 (5): (1-9). [PMID:35501414] |
11. Yu-Fei Zhong, Guang-Ming Bao, Mei Qiu, Yi-Fan Xia, Wei Li, Ying-Qing Tao, Si-Yi Liu, Si-Han Li, Wei Xiao, Yongfan Zhang, Hou-Qun Yuan. (2022) Highly selective and sensitive fluorescent biosensor for the detection of serotonin and its metabolite by Eu3+-Doped Metal-Organic framework. CHEMICAL ENGINEERING JOURNAL, 442 (136272). [PMID:] |
12. Lu Yan, Yang Mei-ling, Shen A-ling, Lin Shan, Peng Mei-zhong, Wang Tian-yi, Lu Zhu-qing, Wang Yi-lian, Peng Jun, Chu Jian-feng. (2022) Pharmacodynamic Mechanism of Kuanxiong Aerosol for Vasodilation and Improvement of Myocardial Ischemia. Chinese Journal of Integrative Medicine, 28 (4): (319-329). [PMID:34897591] |
13. Wang Tingting, Yang Li, Cheng Yuhuan, Zhang Yulian, Ye Jiannong, Chu Qingcui, Cheng Guifang. (2021) Evaluation of homochiral zeolitic imidazolate framework-8 supported open-tubular column by miniaturized capillary electrochromatography with amperometric detection. MICROCHIMICA ACTA, 188 (11): (1-7). [PMID:34635945] |
14. Yun Lei,Guanhong Xu,Fangdi Wei,Jing Yang,Qin Hu. (2014-02-25) Preparation of a stir bar coated with molecularly imprinted polymer and its application in analysis of dopamine in urine.. Journal of pharmaceutical and biomedical analysis, 94 (118-124). [PMID:24561337] |
1. Jin Yuan Zhang, Ying Zhang, Yu Zou, Ze Li Bo Xu, Bo Zhang, Wang Ren. (2024) Physicochemically modulated fluorescence-scattering ratiometric sensor for selective and visual detection of levodopa. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 308 (123746). [PMID:38091648] |
2. Kai Hu, Tiantian Pang, Cheng Yang, Pengzhao Han, Lixin Li, Pan Wang, Zhenqiang Zhang, Wenjie Zhao, Shusheng Zhang. (2023) Simultaneous extraction of hydroxylated polycyclic aromatic hydrocarbons and catecholamines with magnetic boronic acid hypercrosslinked polymers. JOURNAL OF CHROMATOGRAPHY A, 1712 (464491). [PMID:37931428] |
3. Qiang Chen, Lili Zheng, Xiaoqin Deng, Menghan Zhang, Wendi Han, Zhengjun Huang, Chenfang Miao, Shaohuang Weng. (2023) A fluorescence biosensor for tyrosinase activity analysis based on silicon-doped carbon quantum dots. CHEMICAL & PHARMACEUTICAL BULLETIN, (4): [PMID:37704432] |
4. Wenting Lin, Kan Li, Yingjun Qin, Xing Han, Xiaohui Chen, Yuan Ren. (2023) Flunitrazepam induces neurotoxicity in zebrafish through microbiota-gut-brain axis. SCIENCE OF THE TOTAL ENVIRONMENT, 901 (165974). [PMID:37532048] |
5. Huang Liyuan, Su Ruobing, Xi Fengna. (2023) Sensitive detection of noradrenaline in human whole blood based on Au nanoparticles embedded vertically-ordered silica nanochannels modified pre-activated glassy carbon electrodes. Frontiers in Chemistry, 11 [PMID:36874060] |
6. Xin Huang, Rui Wang, Yikai Wang, Changbao Chen, Shuying Liu. (2023) Investigation on property differences of ginseng and American ginseng by spatial metabolomics of neurochemicals with desorption electrospray ionization mass spectrometry imaging. JOURNAL OF ETHNOPHARMACOLOGY, 303 (116006). [PMID:36516905] |
7. Shanshan Zhan, Caihong Xu, Jiandan Chen, Qi Xiao, Zhenzeng Zhou, Zhiyuan Xing, Chunchuan Gu, Zhengzhi Yin, Hongying Liu. (2023) A novel epinephrine biosensor based on gold nanoparticles coordinated polydopamine-functionalized acupuncture needle microelectrode. ELECTROCHIMICA ACTA, 437 (141468). [PMID:] |
8. Bin Liu, Chunmiao Bo, Yan Li, Xiaohua Ma, Bolin Gong, Shengwei Guo. (2022) Preparation of reversed-phase/boronate affinity mixed-mode restricted access materials with zwitterionic polymer outer layers and its extraction properties. JOURNAL OF CHROMATOGRAPHY A, 1679 (463398). [PMID:35964461] |
9. Biying Jiang, Baolong Cao, Zhichun Zhou, Zejiao Li, Can Lv, Jiannan Zhang, Heyuan Zhang, Yajun Wang, Juan Li. (2022) Characterization of Chicken α2A-Adrenoceptor: Molecular Cloning, Functional Analysis, and Its Involvement in Ovarian Follicular Development. Genes, 13 (7): (1113). [PMID:35885896] |
10. Zhu Anni, Wang Tiansheng, Jiang Yuning, Hu Sen, Tang Wanxin, Liu Xinling, Guo Xiaoyu, Ying Ye, Wu Yiping, Wen Ying, Yang Haifeng. (2022) SERS determination of dopamine using metal–organic frameworks decorated with Ag/Au noble metal nanoparticle composite after azo derivatization with p-aminothiophenol. MICROCHIMICA ACTA, 189 (5): (1-9). [PMID:35501414] |
11. Yu-Fei Zhong, Guang-Ming Bao, Mei Qiu, Yi-Fan Xia, Wei Li, Ying-Qing Tao, Si-Yi Liu, Si-Han Li, Wei Xiao, Yongfan Zhang, Hou-Qun Yuan. (2022) Highly selective and sensitive fluorescent biosensor for the detection of serotonin and its metabolite by Eu3+-Doped Metal-Organic framework. CHEMICAL ENGINEERING JOURNAL, 442 (136272). [PMID:] |
12. Lu Yan, Yang Mei-ling, Shen A-ling, Lin Shan, Peng Mei-zhong, Wang Tian-yi, Lu Zhu-qing, Wang Yi-lian, Peng Jun, Chu Jian-feng. (2022) Pharmacodynamic Mechanism of Kuanxiong Aerosol for Vasodilation and Improvement of Myocardial Ischemia. Chinese Journal of Integrative Medicine, 28 (4): (319-329). [PMID:34897591] |
13. Wang Tingting, Yang Li, Cheng Yuhuan, Zhang Yulian, Ye Jiannong, Chu Qingcui, Cheng Guifang. (2021) Evaluation of homochiral zeolitic imidazolate framework-8 supported open-tubular column by miniaturized capillary electrochromatography with amperometric detection. MICROCHIMICA ACTA, 188 (11): (1-7). [PMID:34635945] |
14. Yun Lei,Guanhong Xu,Fangdi Wei,Jing Yang,Qin Hu. (2014-02-25) Preparation of a stir bar coated with molecularly imprinted polymer and its application in analysis of dopamine in urine.. Journal of pharmaceutical and biomedical analysis, 94 (118-124). [PMID:24561337] |