Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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N109573-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $39.90 | |
N109573-250mg | 250mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $85.90 | |
N109573-500mg | 500mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $166.90 | |
N109573-1g | 1g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $264.90 | |
N109573-5g | 5g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $1,188.90 |
Synonyms | (-)-Noradrec | Nor adrenalin | NOREPINEPHRINE [INN] | Sympathin E | NORADRENALINE [JAN] | NOREPINEPHRINE (USP IMPURITY) | Norepinephrine [INN:BAN:JAN] | A56046 | Benzyl alcohol, alpha-(aminomethyl)-3,4-dihydroxy-, (-)- | Levarterenolo | noradrAnaline | No |
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Specifications & Purity | Moligand™, ≥98% |
Storage Temp | Store at 2-8°C,Protected from light,Argon charged |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | AGONIST |
Mechanism of action | Agonist of α 1A-adrenoceptor;Agonist of α 1B-adrenoceptor;Agonist of α 1D-adrenoceptor;Agonist of α 2A-adrenoceptor;Agonist of α 2B-adrenoceptor;Agonist of α 2C-adrenoceptor;Agonist of β 1-adrenoceptor;Agonist of β 2-adrenoceptor;Agonist of β 3-adrenocept |
Product Description | Norepinephrine (Levophed) is an alkaloidal natural product, a neurotransmitter, an adrenergic receptor (AR) agonist, with activating activity on α1, α2, and β1 ARs. Norepinephrine has been used as a vasoactive agent in the treatment of antishock. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol |
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INCHI | InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/t8-/m0/s1 |
InChi Key | SFLSHLFXELFNJZ-QMMMGPOBSA-N |
Canonical SMILES | C1=CC(=C(C=C1C(CN)O)O)O |
Isomeric SMILES | C1=CC(=C(C=C1[C@H](CN)O)O)O |
WGK Germany | 3 |
RTECS | DN5950000 |
PubChem CID | 439260 |
UN Number | 2811 |
Molecular Weight | 169.18 |
Beilstein | 2804840 |
PubChem CID | 439260 |
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ChEMBL Ligand | CHEMBL1437 |
BindingDB Ligand | 50030618 |
DrugBank Ligand | DB00368 |
CAS Registry No. | 51-41-2 |
Wikipedia | Norepinephrine |
RCSB PDB Ligand | LNR, LT4 |
PEP | noradrenaline |
DrugCentral Ligand | 1960 |
GPCRdb Ligand | (-)-noradrenaline |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
J2428263 | Certificate of Analysis | Sep 11, 2024 | N109573 |
I2424533 | Certificate of Analysis | Sep 11, 2024 | N109573 |
I2424532 | Certificate of Analysis | Sep 11, 2024 | N109573 |
I2424531 | Certificate of Analysis | Sep 11, 2024 | N109573 |
I2424526 | Certificate of Analysis | Sep 11, 2024 | N109573 |
I2424527 | Certificate of Analysis | Sep 11, 2024 | N109573 |
I2424528 | Certificate of Analysis | Sep 11, 2024 | N109573 |
I2424529 | Certificate of Analysis | Sep 11, 2024 | N109573 |
I2424530 | Certificate of Analysis | Sep 11, 2024 | N109573 |
C2429656 | Certificate of Analysis | Mar 09, 2024 | N109573 |
C2429657 | Certificate of Analysis | Mar 09, 2024 | N109573 |
E2415071 | Certificate of Analysis | Sep 01, 2022 | N109573 |
K2229798 | Certificate of Analysis | Sep 01, 2022 | N109573 |
K2229799 | Certificate of Analysis | Sep 01, 2022 | N109573 |
F2222435 | Certificate of Analysis | May 28, 2022 | N109573 |
J2317060 | Certificate of Analysis | May 28, 2022 | N109573 |
C2411047 | Certificate of Analysis | May 28, 2022 | N109573 |
Solubility | 0.5 M HCl (50 mg/ml) |
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Sensitivity | Air & Light Sensitive |
Melt Point(°C) | 100-106°C |
Pictogram(s) | GHS06 |
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Signal | Danger |
Hazard Statements | H300:Fatal if swallowed H310:Fatal in contact with skin H330:Fatal if inhaled |
Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P284:[In case of inadequate ventilation] Wear respiratory protection. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P330:Rinse mouth. P262:Do not get in eyes, on skin, or on clothing. P320:Specific treatment is urgent (see ... on this label). P361+P364:Take off immediately all contaminated clothing and wash it before reuse. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P316:Get emergency medical help immediately. |
WGK Germany | 3 |
RTECS | DN5950000 |
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18. Yuanyuan Dong, Chenxing Xu, Lei Zhang. (2021) Construction of 3D Bi/ZnSnO3 hollow microspheres for label-free highly selective photoelectrochemical recognition of norepinephrine. Nanoscale, 13 (20): (9270-9279). [PMID:33982739] [10.1039/D1NR00792K] |
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23. Xiaoxia Liu, Miaomiao Tian, Wenmei Gao, Jinzhong Zhao. (2019) A Simple, Rapid, Fluorometric Assay for Dopamine by In Situ Reaction of Boronic Acids and cis-Diol. Journal of Analytical Methods in Chemistry, 2019 (6540397). [PMID:31032140] [10.1155/2019/6540397] |
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31. Xueyan Shi, Yuan Wang, Cong Peng, Zhenqin Zhang, Jin Chen, Xuemin Zhou, Huijun Jiang. (2017) Enantiorecognition of Tyrosine Based on a Novel Magnetic Electrochemical Chiral Sensor. ELECTROCHIMICA ACTA, 241 (386). [PMID:] [10.1016/j.electacta.2017.04.155] |
32. Dong Yuhao, Liu Jin, Pang Maoda, Du Hechao, Wang Nannan, Awan Furqan, Lu Chengping, Liu Yongjie. (2016) Catecholamine-Stimulated Growth of Aeromonas hydrophila Requires the TonB2 Energy Transduction System but Is Independent of the Amonabactin Siderophore. Frontiers in Cellular and Infection Microbiology, 6 [PMID:28018865] [10.3389/fcimb.2016.00183] |
33. Ling Zhu, Guanhong Xu, Quan Song, Tang Tang, Xu Wang, Fangdi Wei, Qin Hu. (2016) Highly sensitive determination of dopamine by a turn-on fluorescent biosensor based on aptamer labeled carbon dots and nano-graphite. SENSORS AND ACTUATORS B-CHEMICAL, 231 (506). [PMID:] [10.1016/j.snb.2016.03.084] |
34. Nian-Gui Xu, Zhi-Jie Xiao, Ting Zou, Zhi-Ling Huang. (2015) Ameliorative effects of physcion 8-O-β-glucopyranoside isolated from Polygonum cuspidatum on learning and memory in dementia rats induced by Aβ1–40. PHARMACEUTICAL BIOLOGY, 53 (11): (1632-1638). [PMID:25856718] [10.3109/13880209.2014.997251] |
35. Zhengpeng Yang, Xuan Liu, Yumin Wu, Chunjing Zhang. (2015) Modification of carbon aerogel electrode with molecularly imprinted polypyrrole for electrochemical determination of dopamine. SENSORS AND ACTUATORS B-CHEMICAL, 212 (457). [PMID:] [10.1016/j.snb.2015.02.057] |
36. Xi Zhou, Peipei Ma, Anqi Wang, Chenfei Yu, Tao Qian, Shishan Wu, Jian Shen. (2015) Dopamine fluorescent sensors based on polypyrrole/graphene quantum dots core/shell hybrids. BIOSENSORS & BIOELECTRONICS, 64 (404). [PMID:25278481] [10.1016/j.bios.2014.09.038] |
37. Zhiyong Wang, Yanyan Bai, Wenchao Wei, Ning Xia, Yuhui Du. (2013) Magnetic Fe3O4-Based Sandwich-Type Biosensor Using Modified Gold Nanoparticles as Colorimetric Probes for the Detection of Dopamine. Materials, 6 (12): (5690-5699). [PMID:28788417] [10.3390/ma6125690] |
38. Yun Lei,Guanhong Xu,Fangdi Wei,Jing Yang,Qin Hu. (2014-02-25) Preparation of a stir bar coated with molecularly imprinted polymer and its application in analysis of dopamine in urine.. Journal of pharmaceutical and biomedical analysis, 94 (118-124). [PMID:24561337] |
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32. Dong Yuhao, Liu Jin, Pang Maoda, Du Hechao, Wang Nannan, Awan Furqan, Lu Chengping, Liu Yongjie. (2016) Catecholamine-Stimulated Growth of Aeromonas hydrophila Requires the TonB2 Energy Transduction System but Is Independent of the Amonabactin Siderophore. Frontiers in Cellular and Infection Microbiology, 6 [PMID:28018865] [10.3389/fcimb.2016.00183] |
33. Ling Zhu, Guanhong Xu, Quan Song, Tang Tang, Xu Wang, Fangdi Wei, Qin Hu. (2016) Highly sensitive determination of dopamine by a turn-on fluorescent biosensor based on aptamer labeled carbon dots and nano-graphite. SENSORS AND ACTUATORS B-CHEMICAL, 231 (506). [PMID:] [10.1016/j.snb.2016.03.084] |
34. Nian-Gui Xu, Zhi-Jie Xiao, Ting Zou, Zhi-Ling Huang. (2015) Ameliorative effects of physcion 8-O-β-glucopyranoside isolated from Polygonum cuspidatum on learning and memory in dementia rats induced by Aβ1–40. PHARMACEUTICAL BIOLOGY, 53 (11): (1632-1638). [PMID:25856718] [10.3109/13880209.2014.997251] |
35. Zhengpeng Yang, Xuan Liu, Yumin Wu, Chunjing Zhang. (2015) Modification of carbon aerogel electrode with molecularly imprinted polypyrrole for electrochemical determination of dopamine. SENSORS AND ACTUATORS B-CHEMICAL, 212 (457). [PMID:] [10.1016/j.snb.2015.02.057] |
36. Xi Zhou, Peipei Ma, Anqi Wang, Chenfei Yu, Tao Qian, Shishan Wu, Jian Shen. (2015) Dopamine fluorescent sensors based on polypyrrole/graphene quantum dots core/shell hybrids. BIOSENSORS & BIOELECTRONICS, 64 (404). [PMID:25278481] [10.1016/j.bios.2014.09.038] |
37. Zhiyong Wang, Yanyan Bai, Wenchao Wei, Ning Xia, Yuhui Du. (2013) Magnetic Fe3O4-Based Sandwich-Type Biosensor Using Modified Gold Nanoparticles as Colorimetric Probes for the Detection of Dopamine. Materials, 6 (12): (5690-5699). [PMID:28788417] [10.3390/ma6125690] |
38. Yun Lei,Guanhong Xu,Fangdi Wei,Jing Yang,Qin Hu. (2014-02-25) Preparation of a stir bar coated with molecularly imprinted polymer and its application in analysis of dopamine in urine.. Journal of pharmaceutical and biomedical analysis, 94 (118-124). [PMID:24561337] |