Basic Description

Synonyms	L-phenylalanine \| phenylalanine \| 63-91-2 \| 3-Phenyl-L-alanine \| (2S)-2-amino-3-phenylpropanoic acid \| (S)-2-Amino-3-phenylpropanoic acid \| (S)-Phenylalanine \| (L)-Phenylalanine \| 3-Phenylalanine \| (S)-2-Amino-3-phenylpropionic acid \| beta-Phenyl-L-alanine \| Antibiotic FN 1636
Specifications & Purity	Moligand™, Animal Free, USP, JP, Ph.Eur., for cell culture, ≥98.5%
Biochemical and Physiological Mechanisms	L-Phenylalanine is an essential amino acid. It is significantly involved in the synthesis of neurotransmitters such as dopamine, epinephrine, norepinephrine, l-DOPA (Dihydroxyphenylalanine), melanin and thyroxine. L-Phenylalanine metabolism also results i
Storage Temp	Protected from light,Desiccated
Shipped In	Normal
Grade	Animal Free, for cell culture, JP, Moligand™, Ph.Eur., USP

Associated Targets(Human)

GPR139 Tchem Probable G-protein coupled receptor 139 3 Activities

Discover Target: GPR139

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Thrombin 11687 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Carbonic anhydrase II 17698 Activities

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Estrogen receptor alpha 17718 Activities

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Glucocorticoid receptor 14987 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Progesterone receptor 8562 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Muscarinic acetylcholine receptor M2 10671 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Serotonin 1a (5-HT1a) receptor 14969 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Alpha-2a adrenergic receptor 9450 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Androgen Receptor 11781 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Muscarinic acetylcholine receptor M1 12690 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Tyrosinase 717 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GABA receptor alpha-1 subunit 399 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Monoamine oxidase A 11911 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Dopamine D1 receptor 9720 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Acetylcholinesterase 18204 Activities

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Cyclooxygenase-1 9233 Activities

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Norepinephrine transporter 10102 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Serotonin transporter 12625 Activities

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Alpha-1a adrenergic receptor 8359 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mu opioid receptor 19785 Activities

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Dopamine D3 receptor 14368 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Voltage-gated calcium channel alpha2/delta subunit 1 266 Activities

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Dopamine transporter 10535 Activities

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HERG 29587 Activities

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Phosphodiesterase 3A 3309 Activities

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Serotonin 2b (5-HT2b) receptor 10323 Activities

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Thromboxane A2 receptor 5717 Activities

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Thyroid hormone receptor beta-1 7926 Activities

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Phosphodiesterase 4A 1943 Activities

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Adenosine A3 receptor 15931 Activities

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Carbonic anhydrase III 753 Activities

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Carbonic anhydrase VI 993 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Carbonic anhydrase I 13240 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Histamine H3 receptor 10389 Activities

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Vascular endothelial growth factor receptor 2 20924 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Carbonic anhydrase VB 957 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Carbonic anhydrase VA 1168 Activities

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Carbonic anhydrase XIV 1305 Activities

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Cytochrome P450 2D6 33882 Activities

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Carbonic anhydrase XII 6231 Activities

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Cytochrome P450 1A2 26471 Activities

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Cytochrome P450 2C9 32119 Activities

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Cytochrome P450 2C19 29246 Activities

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Carbonic anhydrase IX 8255 Activities

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Cytochrome P450 3A4 53859 Activities

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Inhibitor of apoptosis protein 3 3673 Activities

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Homo sapiens 32628 Activities

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L-type amino acid transporter 1 388 Activities

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Alkaline phosphatase, tissue-nonspecific isozyme 1551 Activities

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Phospholipase A-2-activating protein 44 Activities

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Associated Targets(non-human)

Carbonic anhydrase VII 3 Activities

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Carbonic anhydrase XIII 322 Activities

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Carbonic anhydrase IV 1713 Activities

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Pyruvate kinase isozymes M1/M2 66 Activities

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Intestinal alkaline phosphatase 419 Activities

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Carbonic anhydrase 69 Activities

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Pseudomonas aeruginosa 123386 Activities

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Klebsiella pneumoniae 43867 Activities

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Staphylococcus aureus 210822 Activities

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Staphylococcus epidermidis 22802 Activities

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Escherichia coli 133304 Activities

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Bacillus subtilis 32866 Activities

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Oryza sativa 2923 Activities

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Aspergillus fumigatus 16427 Activities

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Plasmodium falciparum 966862 Activities

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Cryptococcus neoformans 21258 Activities

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Candida albicans 78123 Activities

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Candida parapsilosis 8521 Activities

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Caenorhabditis elegans 1055 Activities

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Rattus norvegicus 775804 Activities

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Sporothrix schenckii 1580 Activities

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MDCK 10148 Activities

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RAW264.7 28094 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NIH3T3 5395 Activities

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Luciferin 4-monooxygenase 66902 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Carbonic anhydrase 15 173 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Trichophyton mentagrophytes 4846 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Nuclear factor erythroid 2-related factor 2 214 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Carbonic anhydrase 2 140 Activities

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Monocarboxylate transporter 10 73 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Monocarboxylate transporter 8 28 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

General amino-acid permease GAP1 481 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Lipopolysaccharide (LPS) 376 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Carbonic anhydrase-like protein, putative 25 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 38078 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	(2S)-2-amino-3-phenylpropanoic acid
INCHI	InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1
InChi Key	COLNVLDHVKWLRT-QMMMGPOBSA-N
Canonical SMILES	C1=CC=C(C=C1)CC(C(=O)O)N
Isomeric SMILES	C1=CC=C(C=C1)C[C@@H](C(=O)O)N
WGK Germany	1
RTECS	AY7535000
PubChem CID	6140
Molecular Weight	165.2
Beilstein	1910408

Certificates

Certificate of Analysis(COA)

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7 results found

Lot Number	Certificate Type	Date	Item
F2425356	Certificate of Analysis	Jun 06, 2024	P110425
G2214321	Certificate of Analysis	Jun 15, 2022	P110425
G2214322	Certificate of Analysis	Jun 15, 2022	P110425
G2214635	Certificate of Analysis	Jun 15, 2022	P110425
B2303907	Certificate of Analysis	May 09, 2022	P110425
D2230002	Certificate of Analysis	May 09, 2022	P110425
B2303908	Certificate of Analysis	Nov 12, 2021	P110425

Chemical and Physical Properties

Solubility	Soluble in water. Slightly soluble in methanol and ethanol. Insoluble in ethyl ether and benzene.
Sensitivity	Light sensitive.
Specific Rotation[α]	-34 ° (C=2, H2O)
Melt Point(°C)	275 °C(dec.)

Safety and Hazards(GHS)

WGK Germany	1
RTECS	AY7535000
Merck Index	7271

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37. Liyun Yang, Yuanping Liao, Zhiqiang Zhou. (2023) An “off-on” fluorescent probe for selective detection of glutathione based on 11-mercaptoundecanoic acid capped gold nanoclusters. OPTICAL MATERIALS, 140 (113867). [PMID:]
38. Lei He, Qian Hu, Liyang Wei, Xuliyang Ge, Ning Yu, Ying Chen. (2023) Unravelling dynamic changes in non-volatile and volatile metabolites of pulses during soaking: An integrated metabolomics approach. FOOD CHEMISTRY, 422 (136231). [PMID:37141754]
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47. Lin Si, Quanbin Fu, Zekun Shi, Tingting Zhang, Qin Hou, Zhixiang Xu, Shiyun Ai. (2023) The fluorescent detection of biothiols and antimicrobial study based on copper(I) iodide coordination polymer. DYES AND PIGMENTS, 215 (111228). [PMID:]
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52. Sun Mengyao, Zhong Zhihua, Wang Yajie, Yu Bohao, Zhang Lei, Zhang Weibing. (2023) Dual-functional lanthanide-MOF probe nanocomposite based on hydroxyapatite nanowires as fluorescent sensor for ascorbic acid. MICROCHIMICA ACTA, 190 (3): (1-9). [PMID:36781571]
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56. Chengxiang Chu, Xianfeng Wang, Yuanyi Deng, Yi Ma, Chengyue Zou, Mei Yang, Huibo Luo, Danqun Huo, Changjun Hou. (2023) Discrimination of Chinese green tea according to tea polyphenols using fluorescence sensor array based on Tb (III) and Eu (III) doped Zr (IV) metal–organic frameworks. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 292 (122380). [PMID:36736046]
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62. Yu Fan, Xin Wang, He Huang, Yumeng Yang, Jinlin Guo, Shajie Luo, Meilian Zhao, Yang Li. (2023) A visual ratiometric fluorescence sensor for glutathione response based on MnO2 nanowires as an oxidant, quencher and recognition unit. Analytical Methods, 15 (4): (419-429). [PMID:36606523]
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66. Songtao Liu, Qi Li, Jiaxin Wang, Xingyu Wang, Nyv Mondele Mbola, Zihui Meng, Min Xue. (2023) Double-Network Hydrogel-Based Photonic Crystal Sensor for Mechanical Force Naked Eye Sensing and Its Application in Medical Compressive or Stretchy Instruments. ACS Applied Materials & Interfaces, 15 (1): (2192–2203). [PMID:36575052]
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70. Yuyang Bei, Kamile Arkin, Yuxin Zheng, Xuesong Ma, Jie Zhao, Huimin Jin, Qingkun Shang. (2023) Construction of a ratiometric fluorescent probe for visual detection of urea in human urine based on carbon dots prepared from Toona sinensis leaves and 5-carboxyfluorescein. ANALYTICA CHIMICA ACTA, 1240 (340733). [PMID:36641152]
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73. Xin Huang, Rui Wang, Yikai Wang, Changbao Chen, Shuying Liu. (2023) Investigation on property differences of ginseng and American ginseng by spatial metabolomics of neurochemicals with desorption electrospray ionization mass spectrometry imaging. JOURNAL OF ETHNOPHARMACOLOGY, 303 (116006). [PMID:36516905]
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76. Tingting Li, Yuxue Ning, Jingyu Pang, Lihua Chen, Fang Zhang, Fang Chai. (2022) Green and facile synthesis of silicon-doped carbon dots and their use in detection of Hg2+ and visualization of latent fingerprints. NEW JOURNAL OF CHEMISTRY, 47 (1): (147-155). [PMID:]
77. Baole Zhang, Wanglong Xu, Chuanlong Yin, Yangming Tang. (2023) Characterization of low-level D-amino acid isomeric impurities of Semaglutide using liquid chromatography-high resolution tandem mass spectrometry. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 224 (115164). [PMID:36462248]
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80. Haoyuan Li, Hongxiang Zhu, Zongyan Quan, Zhiping Chen, Lei Wang, Hui He. (2023) Tailoring of a bionic bifunctional cellulose nanocrystal-based gold nanocluster probe for the detection of intracellular pathological biomarkers. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 224 (1079). [PMID:36309238]
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82. Meijuan Zhang, Jian Cao, Cuiping Huang, Mingming Liu, Yanan Li, Chuanxiao Wang, Yajing Tu. (2023) A fluorescent molecular sensor based on 1,8-naphthalimide for sensitive and rapid detection of human serum albumin. DYES AND PIGMENTS, 208 (110867). [PMID:]
83. Wenping Peng, Nan Wang, Shunmin Wang, Junzhen Wang, Zixiu Bian. (2022) Effect of co-treatment of microwave and exogenous l-phenylalanine on the enrichment of flavonoids in Tartary buckwheat sprouts. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 103 (4): (2014-2022). [PMID:36221181]
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90. Peng Fangfang, Zhou Xin, Cheng Wanmin, Ma Jimei, Jiang Hong. (2022) A Carbon Dots Probe for Specific Determination of Cysteine based on Inner Filter Effect. JOURNAL OF ANALYTICAL CHEMISTRY, 77 (9): (1141-1146). [PMID:]
91. Yuan Yuni, liu Wei, Liu Qi, He Qing, Hu Yuyang, Jiang Xinyu, Chen Xiaoqing. (2022) A dual-channel probe based on copper ion-mediated metal organic framework composite for colorimetric and ratiometric fluorescence monitoring of glyphosate degradation in soil and water. MICROCHIMICA ACTA, 189 (10): (1-10). [PMID:36066687]
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95. Xiuzhen Qiu, Yangyang Li, Yongbiao hua, Dongmei Liu, Kailian Zhou, Yulin Wang, Huishi Guo. (2022) A molecularly imprinted gel photonic crystal sensor for recognition of chiral amino acids. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 283 (121719). [PMID:35952590]
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97. Nan Zhao, Feng Ju, Quanwei Song, Zhiwen Qi, Hao Ling. (2022) Quantitative assessment of the contribution of soil organic matter functional groups and heteroatoms to PAHs adsorption based on the COSMO-RS model. SCIENCE OF THE TOTAL ENVIRONMENT, 846 (157415). [PMID:35850341]
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103. Yingying Xiang, Yujiao Tu, Lei Jiang, Lin Yuan, Ze Liu, Qiang Xie, Xuequan Xiong, Fei Song. (2022) Orange fluorescent dual-mode nanoprobe for selective and sensitive detection of amaranth based on S,N-Doped carbon dots. DYES AND PIGMENTS, 205 (110533). [PMID:]
104. Jing Zhang, Jun-qing Yang, Ying Luo, Jian-sha Li, Tao Gong, Su-qiong Huang, Yan Xiong, Xin-hui Jiang. (2022) Determination of 23 related analytes in bone marrow fluid and hippocampus of C57BL/6 mice following cerebral ischemia–reperfusion injury by HPLC-FLD. BIOMEDICAL CHROMATOGRAPHY, 36 (10): (e5435). [PMID:35763335]
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109. Zhiqiang Zhou, Yuanping Liao, Huiyan Wu, Qi Xiao, Yi Liu, Liyun Yang. (2022) Zeolitic imidazolate framework-8 capped gold nanoclusters as an “on-off-on” fluorescent nanoprobe for sensitive detection of MnO4− and ascorbic acid. MICROPOROUS AND MESOPOROUS MATERIALS, 338 (111971). [PMID:]
110. Baowen Zhang, Lianfang Chen, Maosen Zhang, Caixia Deng, Xiupei Yang. (2022) A gold-silver bimetallic nanocluster-based fluorescent probe for cysteine detection in milk and apple. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 278 (121345). [PMID:35561443]
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118. Shengnan Yin, Changlun Tong. (2022) Lanthanide coordination polymer nanoparticles as a ratiometric fluorescence sensor for real-time and visual detection of tetracycline by a smartphone and test paper based on the analyte-triggered antenna effect and inner filter effect. ANALYTICA CHIMICA ACTA, 1206 (339809). [PMID:35473868]
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152. Meijuan Zhang, Jian Cao, Cuiping Huang, Mingming Liu, Yanan Li, Chuanxiao Wang, Yajing Tu. (2023) A fluorescent molecular sensor based on 1,8-naphthalimide for sensitive and rapid detection of human serum albumin. DYES AND PIGMENTS, 208 (110867). [PMID:]
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165. Xiuzhen Qiu, Yangyang Li, Yongbiao hua, Dongmei Liu, Kailian Zhou, Yulin Wang, Huishi Guo. (2022) A molecularly imprinted gel photonic crystal sensor for recognition of chiral amino acids. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 283 (121719). [PMID:35952590]
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174. Jing Zhang, Jun-qing Yang, Ying Luo, Jian-sha Li, Tao Gong, Su-qiong Huang, Yan Xiong, Xin-hui Jiang. (2022) Determination of 23 related analytes in bone marrow fluid and hippocampus of C57BL/6 mice following cerebral ischemia–reperfusion injury by HPLC-FLD. BIOMEDICAL CHROMATOGRAPHY, 36 (10): (e5435). [PMID:35763335]
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180. Baowen Zhang, Lianfang Chen, Maosen Zhang, Caixia Deng, Xiupei Yang. (2022) A gold-silver bimetallic nanocluster-based fluorescent probe for cysteine detection in milk and apple. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 278 (121345). [PMID:35561443]
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185. Haining Song, Haifeng Zhou, Qianqian Zhuang, Zexin Li, Fenglei Sun, Zhenlei Yuan, Youxin Lou, Guangjun Zhou, Yujun Zhao. (2023) IFE based nanosensor composed of UCNPs and Fe(II)-phenanthroline for detection of hypochlorous acid and periodic acid. JOURNAL OF RARE EARTHS, 41 (200). [PMID:]
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188. Shengnan Yin, Changlun Tong. (2022) Lanthanide coordination polymer nanoparticles as a ratiometric fluorescence sensor for real-time and visual detection of tetracycline by a smartphone and test paper based on the analyte-triggered antenna effect and inner filter effect. ANALYTICA CHIMICA ACTA, 1206 (339809). [PMID:35473868]
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197. Chuanling Mu, Xue Wang, Zhiyuan Ma, Xiaohuan Liu, Wen Li. (2022) Redox and conductive underwater adhesive: an innovative electrode material for convenient construction of flexible and stretchable supercapacitors. Journal of Materials Chemistry A, 10 (13): (7207-7217). [PMID:]
198. Shuting Wang, Laiben Gao, Nan Su, Li Yang, Fengli Gao, Xiaoqiu Dou, Chuanliang Feng. (2022) Inversion of Supramolecular Chirality by In Situ Hydrolyzation of Achiral Diethylene Glycol Motifs. JOURNAL OF PHYSICAL CHEMISTRY B, 126 (6): (1325–1333). [PMID:35113541]
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205. Huang Hui, Xie Shuqian, Deng Lu, Yuan Jie, Yue Ruirui, Xu Jingkun. (2022) Fabrication of rGO/MXene-Pd/rGO hierarchical framework as high-performance electrochemical sensing platform for luteolin detection. MICROCHIMICA ACTA, 189 (2): (1-10). [PMID:35015150]
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SKU	Size	Availability	Price
P110425-25g	25g	In stock	$38.90
P110425-100g	100g	In stock	$125.90
P110425-500g	500g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$564.90

L-Phenylalanine - from non-animal source,EP,JP,USP ；for cell culture,98.5 to 101.0%, high purity , CAS No.63-91-2