Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
SKU | Size | Availability | Price | Qty |
---|---|---|---|---|
P105976-1g | 1g | In stock | $10.90 | |
P105976-5g | 5g | In stock | $29.90 | |
P105976-25g | 25g | In stock | $109.90 | |
P105976-100g | 100g | In stock | $279.90 | |
P105976-500g | 500g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $899.90 |
Synonyms | MFCD00005253 | (S)-proline amide | (2S)-pyrrolidine-2-carboxamide | L-proline amide | (S)-Prolinamide | L-prolinamide | C5H10N2O | h-pro-nh2 | (S)-Pyrrolidine-2-carboxamide | l-Prolineamide | Prolinamide | proline amide | (S)-2-Pyrrolidinecarboxamide |
---|---|
Specifications & Purity | ≥98% |
Shipped In | Normal |
Note | 1g售完停产 |
Product Description | Application It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff. Also it is a efficient organocatalysts for aldol reactions on water. |
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Pubchem Sid | 488187467 |
---|---|
Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488187467 |
IUPAC Name | (2S)-pyrrolidine-2-carboxamide |
INCHI | InChI=1S/C5H10N2O/c6-5(8)4-2-1-3-7-4/h4,7H,1-3H2,(H2,6,8)/t4-/m0/s1 |
InChi Key | VLJNHYLEOZPXFW-BYPYZUCNSA-N |
Canonical SMILES | C1CC(NC1)C(=O)N |
Isomeric SMILES | C1C[C@H](NC1)C(=O)N |
WGK Germany | 3 |
PubChem CID | 111306 |
Molecular Weight | 114.15 |
Beilstein | 80807 |
Reaxy-Rn | 80807 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
H2401406 | Certificate of Analysis | Jul 18, 2024 | P105976 |
H2401407 | Certificate of Analysis | Jul 18, 2024 | P105976 |
H2401408 | Certificate of Analysis | Jul 18, 2024 | P105976 |
D2412291 | Certificate of Analysis | Mar 21, 2024 | P105976 |
D2412295 | Certificate of Analysis | Mar 21, 2024 | P105976 |
D2412300 | Certificate of Analysis | Mar 21, 2024 | P105976 |
J2324050 | Certificate of Analysis | Oct 27, 2023 | P105976 |
B2317274 | Certificate of Analysis | Feb 28, 2023 | P105976 |
C1802043 | Certificate of Analysis | Jan 24, 2022 | P105976 |
C1802044 | Certificate of Analysis | Jan 24, 2022 | P105976 |
D2324716 | Certificate of Analysis | Nov 05, 2021 | P105976 |
Solubility | Insoluble in water, soluble in benzene, ether, soluble in methanol, slightly soluble in ethanol. |
---|---|
Specific Rotation[α] | -106° (C=2,EtOH) |
Boil Point(°C) | 307℃ |
Melt Point(°C) | 123℃ |
Pictogram(s) | GHS07 |
---|---|
Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
Reaxy-Rn | 80807 |
1. Goto Y, Arai-Otsuki S, Tachibana Y, Ichikawa D, Ozaki S, Takahashi H, Iwasawa Y, Okamoto O, Okuda S, Ohta H et al.. (2006) Identification of a novel spiropiperidine opioid receptor-like 1 antagonist class by a focused library approach featuring 3D-pharmacophore similarity.. J Med Chem, 49 (3): (847-9). [PMID:16451050] |
2. Z Chen,T Hobo. (2001-10-09) Chemically L-prolinamide-modified monolithic silica column for enantiomeric separation of dansyl amino acids and hydroxy acids by capillary electrochromatography and mu-high performance liquid chromatography.. Electrophoresis, 22 ((15)): (3339-3346). [PMID:11589299] |
3. Jozef Kozísek,Marek Fronc,Pavol Skubák,Alexander Popkov,Martin Breza,Hartmut Fuess,Carsten Paulmann. (2004-10-13) Electronic structure of the nickel(II) complex of the Schiff base of (S)-N-(2-benzoylphenyl)-1-benzylprolinamide and glycine.. Acta crystallographica. Section A, Foundations of crystallography, 60 ((Pt 5)): (510-516). [PMID:15477692] |
4. Hizuru Nakajima,Katsuhiko Kawata,Hui Shen,Tatsuro Nakagama,Katsumi Uchiyama. (2005-01-29) Chiral separation of NBD-amino acids by ligand-exchange micro-channel electrophoresis.. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 21 ((1)): (67-71). [PMID:15675519] |
5. Sampak Samanta,Jinyun Liu,Rajasekhar Dodda,Cong-Gui Zhao. (2005-11-05) C2-symmetric bisprolinamide as a highly efficient catalyst for direct aldol reaction.. Organic letters, 7 ((23)): (5321-5323). [PMID:16268568] |
6. Rajasekhar Dodda,Cong-Gui Zhao. (2006-10-06) Organocatalytic highly enantioselective synthesis of secondary alpha-hydroxyphosphonates.. Organic letters, 8 ((21)): (4911-4914). [PMID:17020334] |
7. Takashi Kondo,Takahiro Nekado,Isamu Sugimoto,Kenya Ochi,Shigeyuki Takai,Atsushi Kinoshita,Akira Hatayama,Susumu Yamamoto,Kazuhito Kawabata,Hisao Nakai,Masaaki Toda. (2007-10-27) Discovery of long-acting N-(cyanomethyl)-N-alkyl-L-prolinamide inhibitors of dipeptidyl peptidase IV.. Bioorganic & medicinal chemistry, 16 ((1)): (190-208). [PMID:17962025] |
8. Griet Van Zeebroeck,Beatriz Monge Bonini,Matthias Versele,Johan M Thevelein. (2008-12-09) Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor.. Nature chemical biology, 5 ((1)): (45-52). [PMID:19060912] |
9. Tsonko Kolev,Rüdiger W Seidel,Heike Mayer-Figge,Michael Spiteller,William S Sheldrick,Bojidarka B Koleva. (2008-12-23) Crystal structures and spectroscopic properties of ester amide and diamide of squaric acid with prolinamide.. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 72 ((3)): (502-509). [PMID:19101193] |
10. Kazuhiko Mitsui,Sarah A Hyatt,Daniel A Turner,Christopher M Hadad,Jon R Parquette. (2009-07-10) Direct aldol reactions catalyzed by intramolecularly folded prolinamide dendrons: dendrimer effects on stereoselectivity.. Chemical communications (Cambridge, England), ((22)(22)): (3261-3263). [PMID:19587933] |
11. Christopher J Winrow,Keith Q Tanis,Duane R Reiss,Alison M Rigby,Jason M Uslaner,Victor N Uebele,Scott M Doran,Steven V Fox,Susan L Garson,Anthony L Gotter,David M Levine,Anthony J Roecker,Paul J Coleman,Kenneth S Koblan,John J Renger. (2009-07-15) Orexin receptor antagonism prevents transcriptional and behavioral plasticity resulting from stimulant exposure.. Neuropharmacology, 58 ((1)): (185-194). [PMID:19596018] |
12. Patrycja Puchalska,Elfriede Pittler,Marek Trojanowicz,Gerald Gübitz,Martin G Schmid. (2010-04-28) Enantioseparation of amino acids and alpha-hydroxy acids on ligand-exchange continuous beds by capillary electrochromatography.. Electrophoresis, 31 ((9)): (1517-1520). [PMID:20422630] |
13. Jinsuo Gao,Jian Liu,Jianting Tang,Dongmei Jiang,Bo Li,Qihua Yang. (2010-05-29) Chirally functionalized hollow nanospheres containing L-prolinamide: synthesis and asymmetric catalysis.. Chemistry (Weinheim an der Bergstrasse, Germany), 16 ((26)): (7852-7858). [PMID:20509127] |
14. Zhijin Lu,Haibo Mei,Jianlin Han,Yi Pan. (2010-06-25) The mimic of type II aldolases chemistry: asymmetric synthesis of beta-hydroxy ketones by direct aldol reaction.. Chemical biology & drug design, 76 ((2)): (181-186). [PMID:20572810] |
15. Haizhi Zhang,Li Qi,Juan Qiao,Lanqun Mao. (2011-04-05) Determination of sodium benzoate by chiral ligand exchange CE based on its inhibitory activity in D-amino acid oxidase mediated oxidation of D-serine.. Analytica chimica acta, 691 ((1-2)): (103-109). [PMID:21458638] |
16. Hayriye Nevin Naziroglu,Mustafa Durmaz,Selahattin Bozkurt,Abdulkadir Sirit. (2011-04-08) Application of L-proline derivatives as chiral shift reagents for enantiomeric recognition of carboxylic acids.. Chirality, 23 ((6)): (463-471). [PMID:21472784] |
17. Mauro De Nisco,Silvana Pedatella,Semiha Bektaş,Ada Nucci,Romualdo Caputo. (2012-05-12) D-Glucosamine in a chimeric prolinamide organocatalyst for direct asymmetric aldol addition.. Carbohydrate research, 356 (273-277). [PMID:22575747] |
18. Anaëlle Tilborg,Steve Lanners,Bernadette Norberg,Johan Wouters. (2014-02-20) Solid-state-trapped reactive ammonium carbamate self-derivative salts of prolinamide.. ChemistryOpen, 2 ((5-6)): (194-199). [PMID:24551566] |
19. Raita Araki,Ryosei Nishimura,Rie Kuroda,Toshihiro Fujiki,Shintaro Mase,Kazuhiro Noguchi,Yasuhiro Ikawa,Hideaki Maeba,Akihiro Yachie. (2018-04-18) A characteristic flow cytometric pattern with broad forward scatter and narrowed side scatter helps diagnose immune thrombocytopenia (ITP).. International journal of hematology, 108 ((2)): (151-160). [PMID:29663189] |
20. Hidenobu Komeda,Hiroyuki Harada,Shingo Washika,Takeshi Sakamoto,Makoto Ueda,Yasuhisa Asano. (2004-04-07) S-stereoselective piperazine-2-tert-butylcarboxamide hydrolase from Pseudomonas azotoformans IAM 1603 is a novel L-amino acid amidase.. European journal of biochemistry, 271 ((8)): (1465-1475). [PMID:15066172] |
21. Jian Wang,Hao Li,Yujiang Mei,Bihshow Lou,Dingguo Xu,Daiqian Xie,Hua Guo,Wei Wang. (2005-07-02) Direct, facile aldehyde and ketone alpha-selenenylation reactions promoted by L-prolinamide and pyrrolidine sulfonamide organocatalysts.. The Journal of organic chemistry, 70 ((14)): (5678-5687). [PMID:15989353] |
22. Jia-Rong Chen,Hai-Hua Lu,Xin-Yong Li,Lin Cheng,Jian Wan,Wen-Jing Xiao. (2005-09-24) Readily tunable and bifunctional L-prolinamide derivatives: design and application in the direct enantioselective Aldol reactions.. Organic letters, 7 ((20)): (4543-4545). [PMID:16178579] |
23. Zongrui Hou,Jun Wang,Xiaohua Liu,Xiaoming Feng. (2008-04-11) Highly enantioselective strecker reaction of ketoimines catalyzed by an organocatalyst from (S)-BINOL and L-prolinamide.. Chemistry (Weinheim an der Bergstrasse, Germany), 14 ((15)): (4484-4486). [PMID:18399513] |
24. Tor E Kristensen,Kristian Vestli,Kim A Fredriksen,Finn K Hansen,Tore Hansen. (2009-06-16) Synthesis of acrylic polymer beads for solid-supported proline-derived organocatalysts.. Organic letters, 11 ((14)): (2968-2971). [PMID:19522533] |
25. Robert J Young,Wendy Alderton,Anthony D R Angell,Paul J Beswick,David Brown,C Lynn Chambers,Miriam C Crowe,John Dawson,Christopher C F Hamlett,Simon T Hodgson,Savvas Kleanthous,Richard G Knowles,Linda J Russell,Richard Stocker,James M Woolven. (2011-04-13) Heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase; the identification of (2R)-2-pyrrolidinecarboxamidine as a potent and selective haem-co-ordinating inhibitor.. Bioorganic & medicinal chemistry letters, 21 ((10)): (3037-3040). [PMID:21482467] |
26. Stamatis Fotaras,Christoforos G Kokotos,George Kokotos. (2012-06-22) A tripeptide-like prolinamide-thiourea as an aldol reaction catalyst.. Organic & biomolecular chemistry, 10 ((29)): (5613-5619). [PMID:22717593] |
27. Carlos R Baiz,Bartosz Błasiak,Jens Bredenbeck,Minhaeng Cho,Jun-Ho Choi,Steven A Corcelli,Arend G Dijkstra,Chi-Jui Feng,Sean Garrett-Roe,Nien-Hui Ge,Magnus W D Hanson-Heine,Jonathan D Hirst,Thomas L C Jansen,Kijeong Kwac,Kevin J Kubarych,Casey H Londergan,Hiroaki Maekawa,Mike Reppert,Shinji Saito,Santanu Roy,James L Skinner,Gerhard Stock,John E Straub,Megan C Thielges,Keisuke Tominaga,Andrei Tokmakoff,Hajime Torii,Lu Wang,Lauren J Webb,Martin T Zanni. (2020-07-01) Vibrational Spectroscopic Map, Vibrational Spectroscopy, and Intermolecular Interaction.. Chemical reviews, 120 ((15)): (7152-7218). [PMID:32598850] |