Determine the necessary mass, volume, or concentration for preparing a solution.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
Basic Description
| Synonyms | CCRIS 7326 | DTXSID80184817 | THEANINE, L- | L-Theanine (Ngamma-ethyl-L-glutamine) | N-Ethyl L-glutamine | NSC 21308 | Glutamine, N-ethyl-, L- | H-Glu(NHEt)-OH | N?-Ethyl-L-glutamine | MFCD00059653 | CCG-38778 | DB12444 | s3852 | SPECTRUM1505254 | UNII-80 |
|---|---|
| Specifications & Purity | ≥99% |
| Biochemical and Physiological Mechanisms | Amino acid analog of glutamine, commonly found in green tea. Binds to AMPA, kainate, NMDA and group I mGlu receptors. Displays neuroprotective and cognitive enhancing effects. Also shown to modify self-renewal properties of cancer stem cells. |
| Shipped In | Normal |
| Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Associated Targets(Human)
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (0 Activities)
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Names and Identifiers
| Pubchem Sid | 488189744 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488189744 |
| IUPAC Name | (2S)-2-amino-5-(ethylamino)-5-oxopentanoic acid |
| INCHI | InChI=1S/C7H14N2O3/c1-2-9-6(10)4-3-5(8)7(11)12/h5H,2-4,8H2,1H3,(H,9,10)(H,11,12)/t5-/m0/s1 |
| InChi Key | DATAGRPVKZEWHA-YFKPBYRVSA-N |
| Canonical SMILES | CCNC(=O)CCC(C(=O)O)N |
| Isomeric SMILES | CCNC(=O)CC[C@@H](C(=O)O)N |
| WGK Germany | 3 |
| PubChem CID | 439378 |
| Molecular Weight | 174.2 |
| Reaxy-Rn | 1725586 |
Certificates
Certificate of Analysis(COA)
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 B2309504 | Certificate of Analysis | Jan 05, 2023 | T106217 |
| B2309505 | Certificate of Analysis | Jan 05, 2023 | T106217 |
| B2309506 | Certificate of Analysis | Jan 05, 2023 | T106217 |
| B2309508 | Certificate of Analysis | Jan 05, 2023 | T106217 |
| B2309509 | Certificate of Analysis | Jan 05, 2023 | T106217 |
| B2309510 | Certificate of Analysis | Jan 05, 2023 | T106217 |
| B2309511 | Certificate of Analysis | Jan 05, 2023 | T106217 |
| B2309514 | Certificate of Analysis | Jan 05, 2023 | T106217 |
| C2406048 | Certificate of Analysis | Jan 05, 2023 | T106217 |
| H2328048 | Certificate of Analysis | Jan 05, 2023 | T106217 |
| A1903058 | Certificate of Analysis | Oct 20, 2022 | T106217 |
| I2228177 | Certificate of Analysis | Oct 10, 2022 | T106217 |
| G2229161 | Certificate of Analysis | Aug 05, 2022 | T106217 |
| C1812116 | Certificate of Analysis | Jan 26, 2022 | T106217 |
Show more⌵
Chemical and Physical Properties
| Specific Rotation[α] | 8 ° (C=5, H2O) |
|---|---|
| Melt Point(°C) | 207°C |
Safety and Hazards(GHS)
| Pictogram(s) | GHS07 |
|---|---|
| Signal | Warning |
| Hazard Statements | H317:May cause an allergic skin reaction |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P501:Dispose of contents/container to ... P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. |
| WGK Germany | 3 |
| Reaxy-Rn | 1725586 |
Related Documents
Citations of This Product
| 1. Yuqing Zhong, Yongling Lu, Lishuang Lv. (2023) Theanine in Tea: An Effective Scavenger of Single or Multiple Reactive Carbonyl Species at the Same Time. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 71 (45): (17153–17162). [PMID:37906124] [10.1021/acs.jafc.3c05483] |
| 2. Guorong Ma, Pengzheng Luo, Ruiqiang Xu, Rui Ma, Lei Qiu, Chenran Xu, Rang Yang, Yating Li, Zhihao Zhao, Ling Huang, Yanhui Yang, Pei Wang. (2023) Improving the profile and reliability of cytoplasmic proteins from M. tuberculosis using biomimetic affinity chromatography coupled with LC-MS/MS analysis. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1225 (123756). [PMID:37236071] [10.1016/j.jchromb.2023.123756] |
| 3. Anqi Peng, Keke Yu, Shuwei Yu, Yingying Li, Hao Zuo, Ping Li, Juan Li, Jianan Huang, Zhonghua Liu, Jian Zhao. (2023) Aluminum and Fluoride Stresses Altered Organic Acid and Secondary Metabolism in Tea (Camellia sinensis) Plants: Influences on Plant Tolerance, Tea Quality and Safety. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (5): (4640). [PMID:36902071] [10.3390/ijms24054640] |
| 4. Jingna Yan, Anxia Lu, Jirui Kun, Bei Wang, Yiwen Miao, Yingjuan Chen, Chi-Tang Ho, Qing Meng, Huarong Tong. (2023) Characterization of triterpenoids as possible bitter-tasting compounds in teas infected with bird’s eye spot disease. FOOD RESEARCH INTERNATIONAL, 167 (112643). [PMID:37087235] [10.1016/j.foodres.2023.112643] |
| 5. Dingding Liu, Kang Wei, Chenyu Zhang, Haoran Liu, Yang Gong, Yuanyuan Ye, Jiedan Chen, Mingzhe Yao, Liang Chen, Chunlei Ma. (2023) The potential effects of chlorophyll-deficient mutation and tree_age on the accumulation of amino acid components in tea plants. FOOD CHEMISTRY, 411 (135527). [PMID:36701915] [10.1016/j.foodchem.2023.135527] |
| 6. Chengxiang Chu, Xianfeng Wang, Yuanyi Deng, Yi Ma, Chengyue Zou, Mei Yang, Huibo Luo, Danqun Huo, Changjun Hou. (2023) Discrimination of Chinese green tea according to tea polyphenols using fluorescence sensor array based on Tb (III) and Eu (III) doped Zr (IV) metal–organic frameworks. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 292 (122380). [PMID:36736046] [10.1016/j.saa.2023.122380] |
| 7. Yao Fan, Siying Che, Lei Zhang, Chunsong Zhou, Haiyan Fu, Yuanbin She. (2022) Dual channel sensor array based on ZnCdSe QDs – KMnO4: An effective tool for analysis of catechins and green teas. FOOD RESEARCH INTERNATIONAL, 160 (111734). [PMID:36076421] [10.1016/j.foodres.2022.111734] |
| 8. Wang Zixi, Tang Yanfang, Long Lina, Zhang Huihua. (2022) Effects of Dietary L-Theanine on Growth Performance, Antioxidation, Meat Quality, and Intestinal Microflora in White Feather Broilers With Acute Oxidative Stress. Frontiers in Veterinary Science, 9 [PMID:35812843] [10.3389/fvets.2022.889485] |
| 9. Wang Ying, Li ZhiRong, Chen RongXiang. (2022) Simultaneous Determination of Metabolites Related to Arginine Metabolism in Rat plasma by Hydrophilic Interaction Chromatography–Tandem Mass Spectrometry. JOURNAL OF CHROMATOGRAPHIC SCIENCE, 61 (3): (203-210). [PMID:35704851] [10.1093/chromsci/bmac047] |
| 10. Hui-Wen Gu, Xiao-Li Yin, Tian-Qin Peng, Yuan Pan, Hui-Na Cui, Zhi-Quan Li, Weiqing Sun, Baomiao Ding, Xian-Chun Hu, Zi-Hong Zhang, Zhi Liu. (2022) Geographical origin identification and chemical markers screening of Chinese green tea using two-dimensional fingerprints technique coupled with multivariate chemometric methods. FOOD CONTROL, 135 (108795). [PMID:] [10.1016/j.foodcont.2021.108795] |
| 11. Yan Huang, Dandan Pu, Zhilin Hao, Xiao Yang, Yuyu Zhang. (2021) The Effect of Prickly Ash (Zanthoxylum bungeanum Maxim) on the Taste Perception of Stewed Sheep Tail Fat by LC-QTOF-MS/MS and a Chemometrics Analysis. Foods, 10 (11): (2709). [PMID:34828990] [10.3390/foods10112709] |
| 12. Xiuheng Xue, Haiyong He, Cunjun Liu, Li Wang, Lu Wang, Yueji Wang, Luping Wang, Chen Yang, Juhua Wang, Ruyan Hou. (2022) l-Theanine improves emulsification stability and antioxidant capacity of diacylglycerol by hydrophobic binding β-lactoglobulin as emulsion surface stabilizer. FOOD CHEMISTRY, 366 (130557). [PMID:34284195] [10.1016/j.foodchem.2021.130557] |
| 13. Tian-Qin Peng, Xiao-Li Yin, Hui-Wen Gu, Weiqing Sun, Baomiao Ding, Xian-Chun Hu, Li-An Ma, Shu-Dong Wei, Zhi Liu, Shi-Yi Ye. (2021) HPLC-DAD fingerprints combined with chemometric techniques for the authentication of plucking seasons of Laoshan green tea. FOOD CHEMISTRY, 347 (128959). [PMID:33465688] [10.1016/j.foodchem.2020.128959] |
| 14. Yanqin Yang, Jinjie Hua, Yuliang Deng, Yongwen Jiang, Michael C. Qian, Jinjin Wang, Jia Li, Mingming Zhang, Chunwang Dong, Haibo Yuan. (2020) Aroma dynamic characteristics during the process of variable-temperature final firing of Congou black tea by electronic nose and comprehensive two-dimensional gas chromatography coupled to time-of-flight mass spectrometry. FOOD RESEARCH INTERNATIONAL, 137 (109656). [PMID:33233235] [10.1016/j.foodres.2020.109656] |
| 15. Penghui Li, Yujie Xu, Yanrui Zhang, Jiamin Fu, Shuwei Yu, Huimin Guo, Zhihui Chen, Changsong Chen, Xiaogen Yang, Shucai Wang, Jian Zhao. (2020) Metabolite Profiling and Transcriptome Analysis Revealed the Chemical Contributions of Tea Trichomes to Tea Flavors and Tea Plant Defenses. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 68 (41): (11389–11401). [PMID:32852206] [10.1021/acs.jafc.0c04075] |
| 16. Qingyi Wei, Ting Liu, Hongbin Pu, Da-Wen Sun. (2020) Development of a fluorescent microwave-assisted synthesized carbon dots/Cu2+ probe for rapid detection of tea polyphenols. JOURNAL OF FOOD PROCESS ENGINEERING, 43 (7): (e13419). [PMID:] [10.1111/jfpe.13419] |
| 17. Yating Zhang, Lingbiao Gu, Fei Wang, Lingjun Kong, Huili Pang, Guangyong Qin. (2017) Highly Selective and Considerable Subcritical Butane Extraction to Separate Abamectin in Green Tea. Journal of Oleo Science, [PMID:28515380] [10.5650/jos.ess16230] |
| 18. Yating Zhang, Lingbiao Gu, Fei Wang, Lingjun Kong, Guangyong Qin. (2017) Effective Subcritical Butane Extraction of Bifenthrin Residue in Black Tea. MOLECULES, 22 (4): (560). [PMID:28358319] [10.3390/molecules22040560] |
| 19. Yan-Qing Fu,Jie-Qiong Wang,Jian-Xin Chen,Fang Wang,Jun-Feng Yin,Liang Zeng,John Shi,Yong-Quan Xu. (2020-06-17) Effect of baking on the flavor stability of green tea beverages.. Food chemistry, 331 (127258-127258). [PMID:32544652] |
References
| 1. Dias TR et al.. (2019) L-Theanine promotes cultured human Sertoli cells proliferation and modulates glucose metabolism.. Eur J Nutr, 58 (7): (2961-2970). [PMID:31183510] |
| 2. Yuqing Zhong, Yongling Lu, Lishuang Lv. (2023) Theanine in Tea: An Effective Scavenger of Single or Multiple Reactive Carbonyl Species at the Same Time. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 71 (45): (17153–17162). [PMID:37906124] [10.1021/acs.jafc.3c05483] |
| 3. Guorong Ma, Pengzheng Luo, Ruiqiang Xu, Rui Ma, Lei Qiu, Chenran Xu, Rang Yang, Yating Li, Zhihao Zhao, Ling Huang, Yanhui Yang, Pei Wang. (2023) Improving the profile and reliability of cytoplasmic proteins from M. tuberculosis using biomimetic affinity chromatography coupled with LC-MS/MS analysis. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1225 (123756). [PMID:37236071] [10.1016/j.jchromb.2023.123756] |
| 4. Anqi Peng, Keke Yu, Shuwei Yu, Yingying Li, Hao Zuo, Ping Li, Juan Li, Jianan Huang, Zhonghua Liu, Jian Zhao. (2023) Aluminum and Fluoride Stresses Altered Organic Acid and Secondary Metabolism in Tea (Camellia sinensis) Plants: Influences on Plant Tolerance, Tea Quality and Safety. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (5): (4640). [PMID:36902071] [10.3390/ijms24054640] |
| 5. Jingna Yan, Anxia Lu, Jirui Kun, Bei Wang, Yiwen Miao, Yingjuan Chen, Chi-Tang Ho, Qing Meng, Huarong Tong. (2023) Characterization of triterpenoids as possible bitter-tasting compounds in teas infected with bird’s eye spot disease. FOOD RESEARCH INTERNATIONAL, 167 (112643). [PMID:37087235] [10.1016/j.foodres.2023.112643] |
| 6. Dingding Liu, Kang Wei, Chenyu Zhang, Haoran Liu, Yang Gong, Yuanyuan Ye, Jiedan Chen, Mingzhe Yao, Liang Chen, Chunlei Ma. (2023) The potential effects of chlorophyll-deficient mutation and tree_age on the accumulation of amino acid components in tea plants. FOOD CHEMISTRY, 411 (135527). [PMID:36701915] [10.1016/j.foodchem.2023.135527] |
| 7. Chengxiang Chu, Xianfeng Wang, Yuanyi Deng, Yi Ma, Chengyue Zou, Mei Yang, Huibo Luo, Danqun Huo, Changjun Hou. (2023) Discrimination of Chinese green tea according to tea polyphenols using fluorescence sensor array based on Tb (III) and Eu (III) doped Zr (IV) metal–organic frameworks. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 292 (122380). [PMID:36736046] [10.1016/j.saa.2023.122380] |
| 8. Yao Fan, Siying Che, Lei Zhang, Chunsong Zhou, Haiyan Fu, Yuanbin She. (2022) Dual channel sensor array based on ZnCdSe QDs – KMnO4: An effective tool for analysis of catechins and green teas. FOOD RESEARCH INTERNATIONAL, 160 (111734). [PMID:36076421] [10.1016/j.foodres.2022.111734] |
| 9. Wang Zixi, Tang Yanfang, Long Lina, Zhang Huihua. (2022) Effects of Dietary L-Theanine on Growth Performance, Antioxidation, Meat Quality, and Intestinal Microflora in White Feather Broilers With Acute Oxidative Stress. Frontiers in Veterinary Science, 9 [PMID:35812843] [10.3389/fvets.2022.889485] |
| 10. Wang Ying, Li ZhiRong, Chen RongXiang. (2022) Simultaneous Determination of Metabolites Related to Arginine Metabolism in Rat plasma by Hydrophilic Interaction Chromatography–Tandem Mass Spectrometry. JOURNAL OF CHROMATOGRAPHIC SCIENCE, 61 (3): (203-210). [PMID:35704851] [10.1093/chromsci/bmac047] |
| 11. Hui-Wen Gu, Xiao-Li Yin, Tian-Qin Peng, Yuan Pan, Hui-Na Cui, Zhi-Quan Li, Weiqing Sun, Baomiao Ding, Xian-Chun Hu, Zi-Hong Zhang, Zhi Liu. (2022) Geographical origin identification and chemical markers screening of Chinese green tea using two-dimensional fingerprints technique coupled with multivariate chemometric methods. FOOD CONTROL, 135 (108795). [PMID:] [10.1016/j.foodcont.2021.108795] |
| 12. Yan Huang, Dandan Pu, Zhilin Hao, Xiao Yang, Yuyu Zhang. (2021) The Effect of Prickly Ash (Zanthoxylum bungeanum Maxim) on the Taste Perception of Stewed Sheep Tail Fat by LC-QTOF-MS/MS and a Chemometrics Analysis. Foods, 10 (11): (2709). [PMID:34828990] [10.3390/foods10112709] |
| 13. Xiuheng Xue, Haiyong He, Cunjun Liu, Li Wang, Lu Wang, Yueji Wang, Luping Wang, Chen Yang, Juhua Wang, Ruyan Hou. (2022) l-Theanine improves emulsification stability and antioxidant capacity of diacylglycerol by hydrophobic binding β-lactoglobulin as emulsion surface stabilizer. FOOD CHEMISTRY, 366 (130557). [PMID:34284195] [10.1016/j.foodchem.2021.130557] |
| 14. Tian-Qin Peng, Xiao-Li Yin, Hui-Wen Gu, Weiqing Sun, Baomiao Ding, Xian-Chun Hu, Li-An Ma, Shu-Dong Wei, Zhi Liu, Shi-Yi Ye. (2021) HPLC-DAD fingerprints combined with chemometric techniques for the authentication of plucking seasons of Laoshan green tea. FOOD CHEMISTRY, 347 (128959). [PMID:33465688] [10.1016/j.foodchem.2020.128959] |
| 15. Yanqin Yang, Jinjie Hua, Yuliang Deng, Yongwen Jiang, Michael C. Qian, Jinjin Wang, Jia Li, Mingming Zhang, Chunwang Dong, Haibo Yuan. (2020) Aroma dynamic characteristics during the process of variable-temperature final firing of Congou black tea by electronic nose and comprehensive two-dimensional gas chromatography coupled to time-of-flight mass spectrometry. FOOD RESEARCH INTERNATIONAL, 137 (109656). [PMID:33233235] [10.1016/j.foodres.2020.109656] |
| 16. Penghui Li, Yujie Xu, Yanrui Zhang, Jiamin Fu, Shuwei Yu, Huimin Guo, Zhihui Chen, Changsong Chen, Xiaogen Yang, Shucai Wang, Jian Zhao. (2020) Metabolite Profiling and Transcriptome Analysis Revealed the Chemical Contributions of Tea Trichomes to Tea Flavors and Tea Plant Defenses. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 68 (41): (11389–11401). [PMID:32852206] [10.1021/acs.jafc.0c04075] |
| 17. Qingyi Wei, Ting Liu, Hongbin Pu, Da-Wen Sun. (2020) Development of a fluorescent microwave-assisted synthesized carbon dots/Cu2+ probe for rapid detection of tea polyphenols. JOURNAL OF FOOD PROCESS ENGINEERING, 43 (7): (e13419). [PMID:] [10.1111/jfpe.13419] |
| 18. Yating Zhang, Lingbiao Gu, Fei Wang, Lingjun Kong, Huili Pang, Guangyong Qin. (2017) Highly Selective and Considerable Subcritical Butane Extraction to Separate Abamectin in Green Tea. Journal of Oleo Science, [PMID:28515380] [10.5650/jos.ess16230] |
| 19. Yating Zhang, Lingbiao Gu, Fei Wang, Lingjun Kong, Guangyong Qin. (2017) Effective Subcritical Butane Extraction of Bifenthrin Residue in Black Tea. MOLECULES, 22 (4): (560). [PMID:28358319] [10.3390/molecules22040560] |
| 20. Yan-Qing Fu,Jie-Qiong Wang,Jian-Xin Chen,Fang Wang,Jun-Feng Yin,Liang Zeng,John Shi,Yong-Quan Xu. (2020-06-17) Effect of baking on the flavor stability of green tea beverages.. Food chemistry, 331 (127258-127258). [PMID:32544652] |