L189 - 10mM in DMSO, high purity , CAS No.64232-83-3

Item Number

L425256

Grouped product items
SKU	Size	Availability	Price	Qty
L425256-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$69.90

DNA ligase I, III and IV inhibitor

Basic Description

Synonyms	L189 \| 64232-83-3 \| 6-amino-5-(benzylideneamino)-2-sulfanyl-4-pyrimidinol \| (E)-6-amino-5-(benzylideneamino)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one \| L-189 \| CHEMBL4458668 \| 6-amino-5-(benzylideneamino)-2-sulfanylidene-1H-pyrimidin-4-one \| L 189 \| 6-Amino-5-(benzylidene
Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	DNA ligase I, III and IV inhibitor (IC50values are 5, 9 and 5μM respectively) that blocks DNA binding (Ki= 5μM for DNA ligase I). Preferentially inhibits step 2 of the ligation reaction, and inhibits base excision repair (BER) and non-homologous end joini
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads

Associated Targets(Human)

HCT-116 (91556 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

LIG1 Tchem DNA ligase 1 (262 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

LIG3 Tbio DNA ligase 3 (3 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	6-amino-5-(benzylideneamino)-2-sulfanylidene-1H-pyrimidin-4-one
INCHI	InChI=1S/C11H10N4OS/c12-9-8(10(16)15-11(17)14-9)13-6-7-4-2-1-3-5-7/h1-6H,(H4,12,14,15,16,17)
InChi Key	SAKOXVNKDMWWLF-UHFFFAOYSA-N
Canonical SMILES	C1=CC=C(C=C1)C=NC2=C(NC(=S)NC2=O)N
Isomeric SMILES	C1=CC=C(C=C1)C=NC2=C(NC(=S)NC2=O)N
PubChem CID	824710
Molecular Weight	246.29

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Basic Description