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L(-)-Glutathione(oxidised form) - high purity Grade, high purity , CAS No.27025-41-8

25 Citations

high-purity

CAS#: 27025-41-8
Formula: C₂₀H₃₂N₆O₁₂S₂
Molecular Weight: 612.63
Beilstein Registry Number: 1718700
EC Number: 248-170-7
MDL number: MFCD00063106
PubChem CID: 65359

Item Number

L274260

Grouped product items
SKU	Size	Availability	Price
L274260-1g	1g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$99.90
L274260-5g	5g	In stock	$349.90
L274260-25g	25g	In stock	$1,199.90
L274260-100g	100g	In stock	$2,999.90

Basic Description

Synonyms	F20504 \| OXIGLUTATIONE [ORANGE BOOK] \| 4-{N-[(1R)-2-({(2R)-2-((4S)-4-Amino-4-carboxybutanoylamino)-2-[N-(carboxymethyl)carbamoyl]ethyl}disulfanyl)-1-[N-(carboxymethyl)carbamoyl]ethyl]carbamoyl}(2S)-2-aminobutanoic acid \| Oxiglutationum [INN-Latin] \| AS-14
Specifications & Purity	high-purity
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Grade	high-purity

Associated Targets(non-human)

Agtr2 Angiotensin II type 2 (AT-2) receptor (803 Activities)

Discover Target: Agtr2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mc4r Melanocortin receptor 4 (1205 Activities)

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Ltc4s Leukotriene C4 synthase (1 Activities)

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Sigmar1 Sigma opioid receptor (160 Activities)

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Npy1r Neuropeptide Y receptor type 1 (8 Activities)

Discover Target: Npy1r

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Cckar Cholecystokinin A receptor (90 Activities)

Discover Target: Cckar

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Abcc1 Multidrug resistance-associated protein 1 (42 Activities)

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Nos2 Nitric oxide synthase, inducible (3573 Activities)

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Mapk1 MAP kinase ERK2 (650 Activities)

Discover Target: Mapk1

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Mmp9 Matrix metalloproteinase 9 (38 Activities)

Discover Target: Mmp9

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Helicobacter pylori (3113 Activities)

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Mapt Microtubule-associated protein tau (6 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

fba Putative fructose-1,6-bisphosphate aldolase (15559 Activities)

Discover Target: fba

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)

Discover Target: ffp

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Glra2 Glycine receptor (1745 Activities)

Discover Target: Glra2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

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Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	(2S)-2-amino-5-[[(2R)-3-[[(2R)-2-[[(4S)-4-amino-4-carboxybutanoyl]amino]-3-(carboxymethylamino)-3-oxopropyl]disulfanyl]-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
INCHI	InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/t9-,10-,11-,12-/m0/s1
InChi Key	YPZRWBKMTBYPTK-BJDJZHNGSA-N
Canonical SMILES	N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(O)=O)C(=O)NCC(O)=O)C(=O)NCC(O)=O)C(O)=O
Isomeric SMILES	C(CC(=O)N[C@@H](CSSC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N)C(=O)NCC(=O)O)[C@@H](C(=O)O)N
WGK Germany	2
RTECS	MC0556500
PubChem CID	65359
Molecular Weight	612.63
Beilstein	1718700
Reaxy-Rn	8603291

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

6 results found

Lot Number	Certificate Type	Date	Item
F2412061	Certificate of Analysis	Apr 07, 2024	L274260
G2201008	Certificate of Analysis	Apr 07, 2024	L274260
G2201009	Certificate of Analysis	Apr 07, 2024	L274260
G2201010	Certificate of Analysis	Apr 07, 2024	L274260
G2201011	Certificate of Analysis	Apr 07, 2024	L274260
L2411171	Certificate of Analysis	Apr 07, 2024	L274260

Chemical and Physical Properties

Specific Rotation[α]	-105 ° (C=2, H2O)
Melt Point(°C)	178°C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	2
RTECS	MC0556500
Reaxy-Rn	8603291

FAQs and Articles

FAQ

Enzymes and dietary antioxidants

Categories: Technical articles

Tags:

ascorbic acid glutathione Lipoic acid α- tocopherol

Biological enzyme catalysis technology and application

Categories: Technical articles

Tags:

Enzyme Catalyzer Biocatalytic technology

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Jia Lin, Guoqing Yue, Kang Xiao, Deqing Yang, Xuxing Hao, Minlin Zheng, Pumo Cai, Qing'e Ji. (2023) Effects of low-concentration spinetoram wax-based bait stations on Bactrocera dorsalis (Diptera: Tephritidae). PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 197 (21): (105705). [PMID:38072558]
2. Chen Na, Du Na, Shen Ruichen, He Tianpei, Xi Jing, Tan Jie, Bian Guangkai, Yang Yanbing, Liu Tiangang, Tan Weihong, Yu Lilei, Yuan Quan. (2023) Redox signaling-driven modulation of microbial biosynthesis and biocatalysis. Nature Communications, 14 (1): (1-13). [PMID:37884498]
3. Xiaofang Wang, Huiming Wang, Meining Zhang. (2023) A multi-stimuli-responsive nanochannel inspired by biological disulfide bond. TALANTA, 265 (124785). [PMID:37348351]
4. Luo Gu, Qiuyu Zhu, Xiaoyu Zou, Ru Song. (2023) Antibacterial Effect of Shrimp By-Products Hydrolysate on Specific Spoilage Organisms of Squid. MOLECULES, 28 (10): (4105). [PMID:37241846]
5. Jia Kong, Jinyao Hu, Jia Li, Jiaxing Zhang, Yuhe Shen, Tianli Yue, Xihui Shen, Yuefei Wang, Zhonghong Li, Yinqiang Xia. (2023) Rethreading Design of Ratiometric roGFP2 Mimetic Peptide for Hydrogen Peroxide Sensing. ANALYTICAL CHEMISTRY, 95 (21): (8284–8290). [PMID:37161261]
6. Yuwei Du, Lei Cao, Xinlu Li, Tongtong Zhu, Ruhong Yan, Wen-Fei Dong, Li Li. (2023) Preparation and application of high-brightness red carbon quantum dots for pH and oxidized L-glutathione dual response. ANALYST, 148 (10): (2375-2386). [PMID:37129055]
7. Mengfei Liu, Hong Mo, Qingyu Gao, Ling Yuan. (2022) The pH dependence of emulsifying properties for glutathione disulfide at oil-water interfaces. BIOPHYSICAL CHEMISTRY, 282 (106748). [PMID:34959125]
8. Xiang-Rong Cheng, Piao-Han Tu, Wen-Le Dong, Bu-Tao Yu, Shu-Fang Xia, Mitchell N. Muskat, Bin Guan. (2022) Electrophilic thymol isobutyrate from Inula nervosa Wall. (Xiaoheiyao) ameliorates steatosis in HepG2 cells via Nrf2 activation. Journal of Functional Foods, 88 (104895). [PMID:]
9. Qianqian Zhang, Junhua Wang, Zhao Meng, Rui Ling, Hang Ren, Weidong Qin, Zhenglong Wu, Na Shao. (2021) Glutathione Disulfide as a Reducing, Capping, and Mass-Separating Agent for the Synthesis and Enrichment of Gold Nanoclusters. Nanomaterials, 11 (9): (2258). [PMID:34578574]
10. Yufen Lai, Mengyan Li, Xiaofei Liao, Li Zou. (2021) Smartphone-Assisted Colorimetric Detection of Glutathione and Glutathione Reductase Activity in Human Serum and Mouse Liver Using Hemin/G-Quadruplex DNAzyme. MOLECULES, 26 (16): (5016). [PMID:34443603]
11. Songlin Liu, Hao Ma, Jinyu Zhu, Xiao Xia Han, Bing Zhao. (2020) Ferrous cytochrome c-nitric oxide oxidation for quantification of protein S-nitrosylation probed by resonance Raman spectroscopy. SENSORS AND ACTUATORS B-CHEMICAL, 308 (127706). [PMID:]
12. Fengjiao Mao, Kai Yu, Jing He, Qi Zhou, Guangming Zhang, Wenxin Wang, Na Li, Hong Zhang, Jie Jiang. (2019) Real-time monitoring of electroreduction and labelling of disulfide-bonded peptides and proteins by mass spectrometry. ANALYST, 144 (23): (6898-6904). [PMID:31638109]
13. Wang Xiaoqing, Sun Qian, Zhao Liming, Gong Shuwen, Xu Li. (2019) Visualization of hydrogen polysulfides in living cells and in vivo via a near-infrared fluorescent probe. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 24 (7): (1077-1085). [PMID:31515622]
14. Jian-Yu Yang, Ting Yang, Xiao-Yan Wang, Yi-Ting Wang, Meng-Xian Liu, Ming-Li Chen, Yong-Liang Yu, Jian-Hua Wang. (2019) A Novel Three-Dimensional Nanosensing Array for the Discrimination of Sulfur-Containing Species and Sulfur Bacteria. ANALYTICAL CHEMISTRY, 91 (9): (6012–6018). [PMID:30964645]
15. Chengfei Zhao, Xuewen Wang, Lina Wu, Wen Wu, Yanjie Zheng, Liqing Lin, Shaohuang Weng, Xinhua Lin. (2019) Nitrogen-doped carbon quantum dots as an antimicrobial agent against Staphylococcus for the treatment of infected wounds. COLLOIDS AND SURFACES B-BIOINTERFACES, 179 (17). [PMID:30928801]
16. Xingqi Wang, Yong Zhang, Jie Huang, Mengqiu Xia, Liu Liu, Chunling Tian, Rongfeng Hu, Shuangying Gui, Xiaoqin Chu. (2019) Self-assembled hexagonal liquid crystalline gels as novel ocular formulation with enhanced topical delivery of pilocarpine nitrate. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 562 (31). [PMID:30878587]
17. Wang Xingqi, Zhang Yong, Huang Jie, Tian Chunling, Xia Mengqiu, Liu Liu, Li Zhengguang, Cao Jiaojiao, Gui Shuangying, Chu Xiaoqin. (2019) A Novel Phytantriol-Based Lyotropic Liquid Crystalline Gel for Efficient Ophthalmic Delivery of Pilocarpine Nitrate. AAPS PHARMSCITECH, 20 (1): (1-14). [PMID:30603986]
18. Shanshan Wang, Xu Hun, Xiliang Luo. (2018) Photoelectrochemical endocrine-disrupting chemicals aptasenor based on resonance energy transfer between SnSe/GR and AuNPs along with GSSG for signal amplification. SENSORS AND ACTUATORS B-CHEMICAL, 260 (388). [PMID:]
19. Huili Ye, Hao Wang, Faqiong Zhao, Baizhao Zeng. (2017) A one-pot hydrothermal synthesis of graphene/CdS:Mn photocatalyst for photoelectrochemical sensing of glutathione. RSC Advances, 7 (72): (45792-45798). [PMID:]
20. Zihao Zhang, Yongjing Li, Jiaxun Wan, Peihua Long, Jia Guo, Guosong Chen, Changchun Wang. (2017) Preparation of Pt(IV)-crosslinked polymer nanoparticles with an anti-detoxifying effect for enhanced anticancer therapy. Polymer Chemistry, 8 (15): (2410-2422). [PMID:]
21. Lingzhi Zhao, Zhao Li, Liu Zhao, Chenxiao Zhang. (2017) In Vivo Determination of Reduced Thiols in Rat Cerebellum Paraflocculus Following Salicylate-Induced Tinnitus by Fluorescence. ANALYTICAL LETTERS, [PMID:]
22. Yinghan Yan, Cuiling Zhang, Wei Gu, Caiping Ding, Xinchang Li, Yuezhong Xian. (2016) Facile Synthesis of Water-Soluble WS2 Quantum Dots for Turn-On Fluorescent Measurement of Lipoic Acid. Journal of Physical Chemistry C, 120 (22): (12170–12177). [PMID:]
23. Shaohua Guo, Grzegorz Maria Popowicz, Daoming Li, Dongjuan Yuan, Yonghua Wang. (2016) Lid mobility in lipase SMG1 validated using a thiol/disulfide redox potential probe. FEBS Open Bio, 6 (5): (477-483). [PMID:27419053]
24. Jingjing Zhao, Kun Zhang, Ji Ji, Baohong Liu. (2016) Sensitive and label-free quantification of cellular biothiols by competitive surface-enhanced Raman spectroscopy. TALANTA, 152 (196). [PMID:26992511]
25. Lei Ouyang, Lihua Zhu, Jizhou Jiang, Heqing Tang. (2014) A surface-enhanced Raman scattering method for detection of trace glutathione on the basis of immobilized silver nanoparticles and crystal violet probe. ANALYTICA CHIMICA ACTA, 816 (41). [PMID:24580853]

References

1. 张长波. (2022) 单激发双发射氮掺杂碳量子点的制备及其在生物成像和荧光油墨中的应用. 贵州师范大学学报( 自然科学版), 40 (4): (7-14). [PMID:]
2. Jia Lin, Guoqing Yue, Kang Xiao, Deqing Yang, Xuxing Hao, Minlin Zheng, Pumo Cai, Qing'e Ji. (2023) Effects of low-concentration spinetoram wax-based bait stations on Bactrocera dorsalis (Diptera: Tephritidae). PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 197 (21): (105705). [PMID:38072558]
3. Chen Na, Du Na, Shen Ruichen, He Tianpei, Xi Jing, Tan Jie, Bian Guangkai, Yang Yanbing, Liu Tiangang, Tan Weihong, Yu Lilei, Yuan Quan. (2023) Redox signaling-driven modulation of microbial biosynthesis and biocatalysis. Nature Communications, 14 (1): (1-13). [PMID:37884498]
4. Xiaofang Wang, Huiming Wang, Meining Zhang. (2023) A multi-stimuli-responsive nanochannel inspired by biological disulfide bond. TALANTA, 265 (124785). [PMID:37348351]
5. Luo Gu, Qiuyu Zhu, Xiaoyu Zou, Ru Song. (2023) Antibacterial Effect of Shrimp By-Products Hydrolysate on Specific Spoilage Organisms of Squid. MOLECULES, 28 (10): (4105). [PMID:37241846]
6. Jia Kong, Jinyao Hu, Jia Li, Jiaxing Zhang, Yuhe Shen, Tianli Yue, Xihui Shen, Yuefei Wang, Zhonghong Li, Yinqiang Xia. (2023) Rethreading Design of Ratiometric roGFP2 Mimetic Peptide for Hydrogen Peroxide Sensing. ANALYTICAL CHEMISTRY, 95 (21): (8284–8290). [PMID:37161261]
7. Yuwei Du, Lei Cao, Xinlu Li, Tongtong Zhu, Ruhong Yan, Wen-Fei Dong, Li Li. (2023) Preparation and application of high-brightness red carbon quantum dots for pH and oxidized L-glutathione dual response. ANALYST, 148 (10): (2375-2386). [PMID:37129055]
8. Mengfei Liu, Hong Mo, Qingyu Gao, Ling Yuan. (2022) The pH dependence of emulsifying properties for glutathione disulfide at oil-water interfaces. BIOPHYSICAL CHEMISTRY, 282 (106748). [PMID:34959125]
9. Xiang-Rong Cheng, Piao-Han Tu, Wen-Le Dong, Bu-Tao Yu, Shu-Fang Xia, Mitchell N. Muskat, Bin Guan. (2022) Electrophilic thymol isobutyrate from Inula nervosa Wall. (Xiaoheiyao) ameliorates steatosis in HepG2 cells via Nrf2 activation. Journal of Functional Foods, 88 (104895). [PMID:]
10. Qianqian Zhang, Junhua Wang, Zhao Meng, Rui Ling, Hang Ren, Weidong Qin, Zhenglong Wu, Na Shao. (2021) Glutathione Disulfide as a Reducing, Capping, and Mass-Separating Agent for the Synthesis and Enrichment of Gold Nanoclusters. Nanomaterials, 11 (9): (2258). [PMID:34578574]
11. Yufen Lai, Mengyan Li, Xiaofei Liao, Li Zou. (2021) Smartphone-Assisted Colorimetric Detection of Glutathione and Glutathione Reductase Activity in Human Serum and Mouse Liver Using Hemin/G-Quadruplex DNAzyme. MOLECULES, 26 (16): (5016). [PMID:34443603]
12. Songlin Liu, Hao Ma, Jinyu Zhu, Xiao Xia Han, Bing Zhao. (2020) Ferrous cytochrome c-nitric oxide oxidation for quantification of protein S-nitrosylation probed by resonance Raman spectroscopy. SENSORS AND ACTUATORS B-CHEMICAL, 308 (127706). [PMID:]
13. Fengjiao Mao, Kai Yu, Jing He, Qi Zhou, Guangming Zhang, Wenxin Wang, Na Li, Hong Zhang, Jie Jiang. (2019) Real-time monitoring of electroreduction and labelling of disulfide-bonded peptides and proteins by mass spectrometry. ANALYST, 144 (23): (6898-6904). [PMID:31638109]
14. Wang Xiaoqing, Sun Qian, Zhao Liming, Gong Shuwen, Xu Li. (2019) Visualization of hydrogen polysulfides in living cells and in vivo via a near-infrared fluorescent probe. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 24 (7): (1077-1085). [PMID:31515622]
15. Jian-Yu Yang, Ting Yang, Xiao-Yan Wang, Yi-Ting Wang, Meng-Xian Liu, Ming-Li Chen, Yong-Liang Yu, Jian-Hua Wang. (2019) A Novel Three-Dimensional Nanosensing Array for the Discrimination of Sulfur-Containing Species and Sulfur Bacteria. ANALYTICAL CHEMISTRY, 91 (9): (6012–6018). [PMID:30964645]
16. Chengfei Zhao, Xuewen Wang, Lina Wu, Wen Wu, Yanjie Zheng, Liqing Lin, Shaohuang Weng, Xinhua Lin. (2019) Nitrogen-doped carbon quantum dots as an antimicrobial agent against Staphylococcus for the treatment of infected wounds. COLLOIDS AND SURFACES B-BIOINTERFACES, 179 (17). [PMID:30928801]
17. Xingqi Wang, Yong Zhang, Jie Huang, Mengqiu Xia, Liu Liu, Chunling Tian, Rongfeng Hu, Shuangying Gui, Xiaoqin Chu. (2019) Self-assembled hexagonal liquid crystalline gels as novel ocular formulation with enhanced topical delivery of pilocarpine nitrate. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 562 (31). [PMID:30878587]
18. Wang Xingqi, Zhang Yong, Huang Jie, Tian Chunling, Xia Mengqiu, Liu Liu, Li Zhengguang, Cao Jiaojiao, Gui Shuangying, Chu Xiaoqin. (2019) A Novel Phytantriol-Based Lyotropic Liquid Crystalline Gel for Efficient Ophthalmic Delivery of Pilocarpine Nitrate. AAPS PHARMSCITECH, 20 (1): (1-14). [PMID:30603986]
19. Shanshan Wang, Xu Hun, Xiliang Luo. (2018) Photoelectrochemical endocrine-disrupting chemicals aptasenor based on resonance energy transfer between SnSe/GR and AuNPs along with GSSG for signal amplification. SENSORS AND ACTUATORS B-CHEMICAL, 260 (388). [PMID:]
20. Huili Ye, Hao Wang, Faqiong Zhao, Baizhao Zeng. (2017) A one-pot hydrothermal synthesis of graphene/CdS:Mn photocatalyst for photoelectrochemical sensing of glutathione. RSC Advances, 7 (72): (45792-45798). [PMID:]
21. Zihao Zhang, Yongjing Li, Jiaxun Wan, Peihua Long, Jia Guo, Guosong Chen, Changchun Wang. (2017) Preparation of Pt(IV)-crosslinked polymer nanoparticles with an anti-detoxifying effect for enhanced anticancer therapy. Polymer Chemistry, 8 (15): (2410-2422). [PMID:]
22. Lingzhi Zhao, Zhao Li, Liu Zhao, Chenxiao Zhang. (2017) In Vivo Determination of Reduced Thiols in Rat Cerebellum Paraflocculus Following Salicylate-Induced Tinnitus by Fluorescence. ANALYTICAL LETTERS, [PMID:]
23. Yinghan Yan, Cuiling Zhang, Wei Gu, Caiping Ding, Xinchang Li, Yuezhong Xian. (2016) Facile Synthesis of Water-Soluble WS2 Quantum Dots for Turn-On Fluorescent Measurement of Lipoic Acid. Journal of Physical Chemistry C, 120 (22): (12170–12177). [PMID:]
24. Shaohua Guo, Grzegorz Maria Popowicz, Daoming Li, Dongjuan Yuan, Yonghua Wang. (2016) Lid mobility in lipase SMG1 validated using a thiol/disulfide redox potential probe. FEBS Open Bio, 6 (5): (477-483). [PMID:27419053]
25. Jingjing Zhao, Kun Zhang, Ji Ji, Baohong Liu. (2016) Sensitive and label-free quantification of cellular biothiols by competitive surface-enhanced Raman spectroscopy. TALANTA, 152 (196). [PMID:26992511]
26. Lei Ouyang, Lihua Zhu, Jizhou Jiang, Heqing Tang. (2014) A surface-enhanced Raman scattering method for detection of trace glutathione on the basis of immobilized silver nanoparticles and crystal violet probe. ANALYTICA CHIMICA ACTA, 816 (41). [PMID:24580853]

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