Lalistat 2 - 95%, high purity , CAS No.1234569-09-5

  • ≥95%
Item Number
L288746
Grouped product items
SKUSizeAvailabilityPrice Qty
L288746-5mg
5mg
In stock
$124.90
L288746-10mg
10mg
In stock
$190.90
L288746-25mg
25mg
In stock
$429.90
L288746-50mg
50mg
In stock
$801.90
L288746-100mg
100mg
In stock
$1,443.90
L288746-200mg
200mg
In stock
$2,597.90

Selective LAL inhibitor

Basic Description

Specifications & Purity≥95%
Biochemical and Physiological MechanismsSelective lysosomal acid lipase inhibitor (IC50= 152 nM). Exhibits no inhibition of human pancreatic lipase or bovine milk lipoprotein lipase (up to 10 μM).Lalistat-2 is a potent and specific competitive inhibitor of the lysosomal acid lipase (LAL/Lipa).
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
Product Description

Application

Lalistat 2 has been used as a lysosomal acid lipase (LAL) inhibitor to study its effects on hypoxia-inducible factor (HIF) in mice. It has also been used as a LAL inhibitor to study LAL activity on dried blood spot cards.

Associated Targets(Human)

LIPA Tchem Lysosomal acid lipase/cholesteryl ester hydrolase (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
LIPA Tchem Lysosomal acid lipase/cholesteryl ester hydrolase (63 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

lipO Probable esterase LipO (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
lipN Probable lipase/esterase LipN (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
lipI Probable lipase LipH (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
lipM Probable esterase LipM (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
lipR Putative acetyl-hydrolase LipR (2 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
lipT Carboxylic ester hydrolase (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

Pubchem Sid488201389
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488201389
IUPAC Name (4-piperidin-1-yl-1,2,5-thiadiazol-3-yl) piperidine-1-carboxylate
INCHI InChI=1S/C13H20N4O2S/c18-13(17-9-5-2-6-10-17)19-12-11(14-20-15-12)16-7-3-1-4-8-16/h1-10H2
InChi Key PNYYVHOTXOEBEV-UHFFFAOYSA-N
Canonical SMILES C1CCN(CC1)C2=NSN=C2OC(=O)N3CCCCC3
Isomeric SMILES C1CCN(CC1)C2=NSN=C2OC(=O)N3CCCCC3
PubChem CID 46867138
Molecular Weight 296.39

Certificates

Certificate of Analysis(COA)

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12 results found

Lot NumberCertificate TypeDateItem
D23211127Certificate of AnalysisMar 18, 2023 L288746
D23211188Certificate of AnalysisMar 18, 2023 L288746
D23211293Certificate of AnalysisMar 18, 2023 L288746
D23211300Certificate of AnalysisMar 18, 2023 L288746
D23211306Certificate of AnalysisMar 18, 2023 L288746
D23211307Certificate of AnalysisMar 18, 2023 L288746
D23211309Certificate of AnalysisMar 18, 2023 L288746
D23211329Certificate of AnalysisMar 18, 2023 L288746
D23211343Certificate of AnalysisMar 18, 2023 L288746
D23211354Certificate of AnalysisMar 18, 2023 L288746
D23211370Certificate of AnalysisMar 18, 2023 L288746
D23211378Certificate of AnalysisMar 18, 2023 L288746

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Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 29.64, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 29.64, Max Conc. mM: 100

Safety and Hazards(GHS)

RIDADR NONHforallmodesoftransport

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Solution Calculators