Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
SKU | Size | Availability | Price | Qty |
---|---|---|---|---|
L288746-5mg | 5mg | In stock | $124.90 | |
L288746-10mg | 10mg | In stock | $190.90 | |
L288746-25mg | 25mg | In stock | $429.90 | |
L288746-50mg | 50mg | In stock | $801.90 | |
L288746-100mg | 100mg | In stock | $1,443.90 | |
L288746-200mg | 200mg | In stock | $2,597.90 |
Selective LAL inhibitor
Specifications & Purity | ≥95% |
---|---|
Biochemical and Physiological Mechanisms | Selective lysosomal acid lipase inhibitor (IC50= 152 nM). Exhibits no inhibition of human pancreatic lipase or bovine milk lipoprotein lipase (up to 10 μM).Lalistat-2 is a potent and specific competitive inhibitor of the lysosomal acid lipase (LAL/Lipa). |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Product Description | Application Lalistat 2 has been used as a lysosomal acid lipase (LAL) inhibitor to study its effects on hypoxia-inducible factor (HIF) in mice. It has also been used as a LAL inhibitor to study LAL activity on dried blood spot cards. |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
---|
Pubchem Sid | 488201389 |
---|---|
Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488201389 |
IUPAC Name | (4-piperidin-1-yl-1,2,5-thiadiazol-3-yl) piperidine-1-carboxylate |
INCHI | InChI=1S/C13H20N4O2S/c18-13(17-9-5-2-6-10-17)19-12-11(14-20-15-12)16-7-3-1-4-8-16/h1-10H2 |
InChi Key | PNYYVHOTXOEBEV-UHFFFAOYSA-N |
Canonical SMILES | C1CCN(CC1)C2=NSN=C2OC(=O)N3CCCCC3 |
Isomeric SMILES | C1CCN(CC1)C2=NSN=C2OC(=O)N3CCCCC3 |
PubChem CID | 46867138 |
Molecular Weight | 296.39 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
D23211127 | Certificate of Analysis | Mar 18, 2023 | L288746 |
D23211188 | Certificate of Analysis | Mar 18, 2023 | L288746 |
D23211293 | Certificate of Analysis | Mar 18, 2023 | L288746 |
D23211300 | Certificate of Analysis | Mar 18, 2023 | L288746 |
D23211306 | Certificate of Analysis | Mar 18, 2023 | L288746 |
D23211307 | Certificate of Analysis | Mar 18, 2023 | L288746 |
D23211309 | Certificate of Analysis | Mar 18, 2023 | L288746 |
D23211329 | Certificate of Analysis | Mar 18, 2023 | L288746 |
D23211343 | Certificate of Analysis | Mar 18, 2023 | L288746 |
D23211354 | Certificate of Analysis | Mar 18, 2023 | L288746 |
D23211370 | Certificate of Analysis | Mar 18, 2023 | L288746 |
D23211378 | Certificate of Analysis | Mar 18, 2023 | L288746 |
Solubility | Solvent:DMSO, Max Conc. mg/mL: 29.64, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 29.64, Max Conc. mM: 100 |
---|
RIDADR | NONHforallmodesoftransport |
---|