Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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L121090-25mg | 25mg | In stock | $35.90 | |
L121090-100mg | 100mg | In stock | $110.90 |
Synonyms | Allocor | NSC-7533 | Digilanogen C | Digilanide C | Lanocide-C | 5RR3JFZ771 | Cedilanid | NSC-119991 | Lanatosid C | DTXSID7023198 | Lanatigen C | Cetosanol | lanatoside C | Isolanid | Isolanide | Celanid | Desacetyllanatoside | Ceglunate | Celadigal |
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Specifications & Purity | ≥95% |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Action Type | INHIBITOR |
Mechanism of action | Sodium/potassium-transporting ATPase inhibitor |
Product Description | Lanatoside C is a cardiac glycoside, can be used in the treatment of congestive heart failure and cardiac arrhythmia.Lanatoside C has an IC50 of 0.19 μM for dengue virus infection in HuH-7 cells. Lanatoside C can effectively inhibit all four serotypes of dengue virus, flavivirus Kunjin, alphavirus Chikungunya, Sindbis virus and the human enterovirus 71 |
ALogP | 0.2 |
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IUPAC Name | [(2R,3R,4S,6S)-6-[(2R,3S,4S,6S)-6-[(2R,3S,4S,6R)-6-[[(3S,5R,8R,9S,10S,12R,13S,14S,17R)-12,14-dihydroxy-10,13-dimethyl-17-(5-oxo-2H-furan-3-yl)-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-yl]oxy]-4-hydroxy-2-methyloxan-3-yl]oxy-4-hydroxy-2-methyloxan-3-yl]oxy-2-methyl-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-4-yl] acetate |
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INCHI | InChI=1S/C49H76O20/c1-21-43(67-38-17-32(53)44(22(2)62-38)68-39-18-33(64-24(4)51)45(23(3)63-39)69-46-42(58)41(57)40(56)34(19-50)66-46)31(52)16-37(61-21)65-27-9-11-47(5)26(14-27)7-8-29-30(47)15-35(54)48(6)28(10-12-49(29,48)59)25-13-36(55)60-20-25/h13,21-23,26-35,37-46,50,52-54,56-59H,7-12,14-20H2,1-6H3/t21-,22-,23-,26-,27+,28-,29-,30+,31+,32+,33+,34-,35-,37+,38+,39+,40-,41+,42-,43-,44-,45-,46+,47+,48+,49+/m1/s1 |
InChi Key | JAYAGJDXJIDEKI-PTGWOZRBSA-N |
Canonical SMILES | C[C@H]1O[C@H](C[C@H](O)[C@@H]1O[C@H]2C[C@H](O)[C@H](O[C@H]3C[C@H](OC(C)=O)[C@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)[C@@H](C)O3)[C@@H](C)O2)O[C@H]5CC[C@@]6(C)[C@H](CC[C@@H]7[C@@H]6C[C@@H](O)[C@]8(C)[C@H](CC[C@]78O)C9=CC(=O)OC9)C5 |
Isomeric SMILES | C[C@@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2CC[C@]3([C@@H](C2)CC[C@@H]4[C@@H]3C[C@H]([C@]5([C@@]4(CC[C@@H]5C6=CC(=O)OC6)O)C)O)C)O)O[C@H]7C[C@@H]([C@@H]([C@H](O7)C)O[C@H]8C[C@@H]([C@@H]([C@H](O8)C)O[C@H]9[C@@H]([C@H]([C@@H]([C@H](O9)CO)O)O)O)OC(=O)C)O |
WGK Germany | 3 |
PubChem CID | 656630 |
Molecular Weight | 985.12 |
Enter Lot Number to search for COA:
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Lot Number | Certificate Type | Date | Item |
---|---|---|---|
G2429400 | Certificate of Analysis | Jul 05, 2024 | L121090 |
G2429401 | Certificate of Analysis | Jul 05, 2024 | L121090 |
B23211018 | Certificate of Analysis | Jan 04, 2023 | L121090 |
B23211110 | Certificate of Analysis | Jan 04, 2023 | L121090 |
Pictogram(s) | GHS06 |
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Signal | Danger |
Hazard Statements | H301:Toxic if swallowed H311:Toxic in contact with skin H331:Toxic if inhaled |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER/doctor/... P311:Call a POISON CENTER or doctor/... |
WGK Germany | 3 |
Starting at $241.90
1. P Sandouk,J M Scherrmann,M Galliot,R Bourdon. (1986-07-05) [Guidelines for prescription of the assay of digitalis glycosides by immunologic methods].. Presse medicale (Paris, France : 1983), 15 ((27)): (1273-1275). [PMID:2945182] |
2. P H Jiao,L Jin,Q Fang,L Xu,M Y Xie. (1986-06-01) [Clinical application of the determination of serum digoxin concentration].. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 8 ((3)): (214-217). [PMID:2946462] |
3. T F Huang,M L Wu. (1987-11-01) Electrophysiological study on hypertrophied and ischemic myocardial of rats.. Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association, 86 ((11)): (1156-1160). [PMID:2965213] |
4. T Bogdanik,M Warmus,W Geraga,J Zambrzycki. (1986-08-01) [Practical use of computer technics and nomograms in controlling treatment using digitalis preparations].. Polskie Archiwum Medycyny Wewnetrznej, 76 ((2)): (80-88). [PMID:3575140] |
5. T Imamura,A Takeshita,T Ashihara,K Yamamoto,S Hoka,M Nakamura. (1985-01-01) Digitalis-induced augmentation of cardiopulmonary baroreflex control of forearm vascular resistance.. Circulation, 71 ((1)): (11-16). [PMID:3964711] |
6. L M Vlasenko,E G Nikolaeva,A N Lavreshin. (1985-04-01) [Determination of isolanid in cadaveric material].. Sudebno-meditsinskaia ekspertiza, 28 ((2)): (51-51). [PMID:4024201] |
7. G Lembo,V Rendina,G Iaccarino,N De Luca,B Ricciardelli,M Volpe,B Trimarco. (1993-12-01) Digitalis restores the forearm sympathetic response to cardiopulmonary receptor unloading in hypertensive patients with left ventricular hypertrophy.. Journal of hypertension, 11 ((12)): (1395-1402). [PMID:8133021] |
8. D R Qiao. (1993-04-01) [A study on the hemodynamic effect of cedilanid in the treatment of acute myocardial infarction].. Zhonghua xin xue guan bing za zhi, 21 ((2)): (83-84). [PMID:8223168] |
9. Y Kesim,C Marangoz,M Ayyildiz,N Tasçi,E Agar,H Sahinoglu. (1994-04-01) The effects of the purinergic system on digitalis-induced epileptiform activity.. Journal of basic and clinical physiology and pharmacology, 5 ((2)): (167-178). [PMID:8736047] |
10. H Saito,W Kawaguchi,M Iwata,K Maekawa,T Tanimoto,S Okada. (2000-08-12) [Lanatoside C Reference Standard (Control 981) of National Institute of Health Sciences].. Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences, ((117)(117)): (192-194). [PMID:10939857] |
11. Davy Guillarme,Elia Grata,Gaetan Glauser,Jean-Luc Wolfender,Jean-Luc Veuthey,Serge Rudaz. (2009-03-03) Some solutions to obtain very efficient separations in isocratic and gradient modes using small particles size and ultra-high pressure.. Journal of chromatography. A, 1216 ((15)): (3232-3243). [PMID:19251260] |
12. Christian E Badr,Thomas Wurdinger,Jonas Nilsson,Johanna M Niers,Michael Whalen,Alexei Degterev,Bakhos A Tannous. (2011-07-16) Lanatoside C sensitizes glioblastoma cells to tumor necrosis factor-related apoptosis-inducing ligand and induces an alternative cell death pathway.. Neuro-oncology, 13 ((11)): (1213-1224). [PMID:21757445] |
13. Yoshihiro Ueda,Kenji Mishiro,Keisuke Yoshida,Takumi Furuta,Takeo Kawabata. (2012-08-09) Regioselective diversification of a cardiac glycoside, lanatoside C, by organocatalysis.. The Journal of organic chemistry, 77 ((18)): (7850-7857). [PMID:22870937] |
14. Vasudevan Aparna,Kesavan Dineshkumar,Narasumani Mohanalakshmi,Devadasan Velmurugan,Waheeta Hopper. (2014-07-16) Identification of natural compound inhibitors for multidrug efflux pumps of Escherichia coli and Pseudomonas aeruginosa using in silico high-throughput virtual screening and in vitro validation.. PloS one, 9 ((7)): (e101840-e101840). [PMID:25025665] |
15. Min-Wu Chao,Tzu-Hsuan Chen,Han-Li Huang,Yu-Wei Chang,Wei-Chun HuangFu,Yu-Ching Lee,Che-Ming Teng,Shiow-Lin Pan. (2017-04-08) Lanatoside C, a cardiac glycoside, acts through protein kinase Cδ to cause apoptosis of human hepatocellular carcinoma cells.. Scientific reports, 7 (46134-46134). [PMID:28387249] |
16. Vahap Murat Kutluay,Toshiaki Makino,Makoto Inoue,Iclal Saracoglu. (2019-02-09) New knowledge about old drugs; a cardenolide type glycoside with cytotoxic effect and unusual secondary metabolites from Digitalis grandiflora Miller.. Fitoterapia, 134 (73-80). [PMID:30735707] |
17. Doris L LaRock,Jenna S Sands,Ethan Ettouati,Marine Richard,Paul J Bushway,Eric D Adler,Victor Nizet,Christopher N LaRock. (2019-07-14) Inflammasome inhibition blocks cardiac glycoside cell toxicity.. The Journal of biological chemistry, 294 ((34)): (12846-12854). [PMID:31300552] |
18. Baradwaj Gopal Ravi,Mary Grace E Guardian,Rebecca Dickman,Zhen Q Wang. (2020-02-10) Profiling and structural analysis of cardenolides in two species of Digitalis using liquid chromatography coupled with high-resolution mass spectrometry.. Journal of chromatography. A, 1618 (460903-460903). [PMID:32035664] |
19. P E Santos,S D Souza,L Freire-Maia,A P Almeida. (1990-01-01) Effects of crotoxin on the isolated guinea pig heart.. Toxicon : official journal of the International Society on Toxinology, 28 ((2)): (215-224). [PMID:2339436] |
20. T Sechser,R Petrásek,L Stika,Z Modr,J Elis,J Malý. (1989-11-01) Contribution of clinical pharmacology to a rational use of cardiac glycosides in Czechoslovakia.. Polish journal of pharmacology and pharmacy, 41 ((6)): (527-532). [PMID:2485902] |
21. G Weigl. (1989-01-01) [Use of digitalis 1981 to 1988 in the Frankfurt (Oder) district].. Zeitschrift fur arztliche Fortbildung, 83 ((22)): (1115-1116). [PMID:2629335] |
22. R Cristodorescu,G Deutsch,S Drăgan. (1989-01-01) Clinical utility of plasma digoxin measurements.. Medecine interne, 27 ((1)): (25-32). [PMID:2749155] |
23. A Marinov. (1987-01-01) [Treatment of patients with acute digitalis poisoning by charcoal hemoperfusion].. Vutreshni bolesti, 26 ((5)): (46-50). [PMID:3433730] |
24. F Orosz,M Nuridsány,J Ovádi. (1986-07-01) Isolation and quantitative determination of some cardioactive glycosides from Digitalis lanata by high-performance liquid chromatography.. Analytical biochemistry, 156 ((1)): (171-175). [PMID:3740407] |
25. A Takeshita,T Imamura. (1986-07-01) Effects of digitalis on cardiopulmonary baroreflex in man.. Japanese circulation journal, 50 ((7)): (671-674). [PMID:3773234] |
26. A Tracqui,P Kintz,B Ludes,P Mangin. (1997-04-25) High-performance liquid chromatography-ionspray mass spectrometry for the specific determination of digoxin and some related cardiac glycosides in human plasma.. Journal of chromatography. B, Biomedical sciences and applications, 692 ((1)): (101-109). [PMID:9187389] |
27. Iu N Zamotaev,Iu A Kremnev,S E Podshibiakin. (2005-08-25) [Cardiac glycosides in complex treatment of patients with heart failure and supraventricular arrhythmias].. Klinicheskaia meditsina, 83 ((7)): (59-63). [PMID:16117429] |
28. Meliza G Roscani,Silméia G Zanati,Cláudia G Magalhães,Vera T M Borges,Beatriz B Matsubara. (2009-11-07) Digitalis-like induced arrhythmia in a patient with rheumatic mitral regurgitation complicated by preeclampsia.. Hypertension in pregnancy, 29 ((2)): (148-152). [PMID:19891530] |
29. Yan Yi Cheung,Karen Caiyun Chen,Huixin Chen,Eng Khuan Seng,Justin Jang Hann Chu. (2014-09-25) Antiviral activity of lanatoside C against dengue virus infection.. Antiviral research, 111 (93-99). [PMID:25251726] |
30. Marika H Tesselaar,Thomas Crezee,Imke Schuurmans,Danny Gerrits,James Nagarajah,Otto C Boerman,Ilse van Engen-van Grunsven,Johannes W A Smit,Romana T Netea-Maier,Theo S Plantinga. (2017-12-16) Digitalislike Compounds Restore hNIS Expression and Iodide Uptake Capacity in Anaplastic Thyroid Cancer.. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 59 ((5)): (780-786). [PMID:29242405] |
31. Yudong Hu,Kaikai Yu,Gang Wang,Depeng Zhang,Chaoji Shi,Yunhe Ding,Duo Hong,Dan Zhang,Huiqiong He,Lei Sun,Jun-Nian Zheng,Shuyang Sun,Feng Qian. (2018-02-24) Lanatoside C inhibits cell proliferation and induces apoptosis through attenuating Wnt/β-catenin/c-Myc signaling pathway in human gastric cancer cell.. Biochemical pharmacology, 150 (280-292). [PMID:29475060] |
32. Georg Petschenka,Colleen S Fei,Juan J Araya,Susanne Schröder,Barbara N Timmermann,Anurag A Agrawal. (2018-10-17) Relative Selectivity of Plant Cardenolides for Na+/K+-ATPases From the Monarch Butterfly and Non-resistant Insects.. Frontiers in plant science, 9 (1424-1424). [PMID:30323822] |
33. Dhanasekhar Reddy,Ranjith Kumavath,Preetam Ghosh,Debmalya Barh. (2019-12-01) Lanatoside C Induces G2/M Cell Cycle Arrest and Suppresses Cancer Cell Growth by Attenuating MAPK, Wnt, JAK-STAT, and PI3K/AKT/mTOR Signaling Pathways.. Biomolecules, 9 ((12)): [PMID:31783627] |