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L275019-1mg

1mg

Available within 4-8 weeks(?)

$869.90

Basic Description

Synonyms	(4R)-4-[(1R,4Z,8E,10Z,12S,15R,17R)-17-hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl]-1,3-thiazolidin-2-one \| 2-THIAZOLIDINONE, 4-(17-HYDROXY-5,12-DIMETHYL-3-OXO-2,16-DIOXABICYCLO(13.3.1)NONADECA-4,8,10-TRIEN-17-YL)-, (1R
Specifications & Purity	≥93%
Biochemical and Physiological Mechanisms	Actin polymerization inhibitor. Potent antiproliferative agent. Stabilizes monomeric G-actin. Shows greater potency than Latrunculin B . Binds actin monomers near the nucleotide binding cleft with 1:1 stoichiometry. Inhibits growth of cancer cell lines (I
Storage Temp	Protected from light,Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions.

Associated Targets(Human)

LCK Tclin Tyrosine-protein kinase LCK (9212 Activities)

Discover Target: LCK

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A498 (42825 Activities)

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ACHN (49357 Activities)

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CAKI-1 (44928 Activities)

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CCRF-CEM (65223 Activities)

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COLO 205 (50209 Activities)

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DU-145 (51482 Activities)

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HL-60 (67320 Activities)

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HT-29 (80576 Activities)

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K562 (73714 Activities)

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KM12 (47707 Activities)

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M14 (47487 Activities)

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MCF7 (126967 Activities)

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MOLT-4 (49676 Activities)

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OVCAR-3 (48710 Activities)

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OVCAR-4 (44535 Activities)

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OVCAR-5 (45555 Activities)

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OVCAR-8 (47708 Activities)

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PC-3 (62116 Activities)

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RPMI-8226 (44974 Activities)

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RXF 393 (41971 Activities)

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SF-295 (48000 Activities)

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SK-MEL-2 (46422 Activities)

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SK-MEL-28 (48833 Activities)

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SK-MEL-5 (47095 Activities)

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SK-OV-3 (52876 Activities)

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SN12C (47755 Activities)

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SNB-19 (46794 Activities)

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TK-10 (45540 Activities)

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U-251 (51189 Activities)

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U-937 (7138 Activities)

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UACC-257 (46019 Activities)

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UACC-62 (47335 Activities)

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UO-31 (46270 Activities)

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786-0 (47912 Activities)

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A549 (127892 Activities)

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NCI/ADR-RES (33767 Activities)

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T47D (39041 Activities)

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EKVX (44102 Activities)

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NCI-H322M (45589 Activities)

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HCC 2998 (41480 Activities)

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HCT-116 (91556 Activities)

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HOP-92 (41141 Activities)

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Hs-578T (29457 Activities)

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NCI-H460 (60772 Activities)

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SF-268 (49410 Activities)

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IGROV-1 (47897 Activities)

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LOX IMVI (44321 Activities)

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HOP-62 (47048 Activities)

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MDA-MB-435 (38290 Activities)

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Associated Targets(non-human)

Aspergillus flavus (8875 Activities)

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Saccharomyces cerevisiae (19171 Activities)

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Trypanosoma brucei brucei (13300 Activities)

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Candida albicans (78123 Activities)

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Mus musculus (284745 Activities)

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A10 (235 Activities)

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P388 (20296 Activities)

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MC-38 (857 Activities)

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3Y1 cell line (119 Activities)

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NIH3T3 (5395 Activities)

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ABC1 ATP binding cassette transporter Abc1p (50 Activities)

Discover Target: ABC1

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Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	(4R)-4-[(1R,4Z,8E,10Z,12S,15R,17R)-17-hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl]-1,3-thiazolidin-2-one
INCHI	InChI=1S/C22H31NO5S/c1-15-7-5-3-4-6-8-16(2)11-20(24)27-18-12-17(10-9-15)28-22(26,13-18)19-14-29-21(25)23-19/h3-5,7,11,15,17-19,26H,6,8-10,12-14H2,1-2H3,(H,23,25)/b4-3+,7-5-,16-11-/t15-,17-,18-,19+,22-/m1/s1
InChi Key	DDVBPZROPPMBLW-IZGXTMSKSA-N
Canonical SMILES	CC1CCC2CC(CC(O2)(C3CSC(=O)N3)O)OC(=O)C=C(CCC=CC=C1)C
Isomeric SMILES	C[C@H]/1CC[C@@H]2C[C@H](C[C@@](O2)([C@@H]3CSC(=O)N3)O)OC(=O)/C=C(\CC/C=C/C=C1)/C
PubChem CID	445420
Molecular Weight	421.55

Certificates

Certificate of Analysis(COA)

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Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number	Certificate Type	Date	Item
L2307555	Certificate of Analysis	Sep 05, 2024	L275019
G2227264	Certificate of Analysis	Jun 28, 2022	L275019

Chemical and Physical Properties

Solubility	Soluble in ethanol to 10 mM and in DMSO to 10 mM
Sensitivity	light sensitive

Alternative Products

References

1. Bun P et al.. (2018) A disassembly-driven mechanism explains F-actin-mediated chromosome transport in starfish oocytes.. Elife, 7 [PMID:29350616]
2. Kasioulis I et al.. (2022) A lateral protrusion latticework connects neuroepithelial cells and is regulated during neurogenesis.. J Cell Sci, 135 (6): [PMID:35217862]
3. Herbomel G et al.. (2017) Actomyosin-generated tension on cadherin is similar between dividing and non-dividing epithelial cells in early Xenopus laevis embryos.. Sci Rep, 7 (45058). [PMID:28327558]
4. Ackermann F et al.. (2019) Critical role for Piccolo in synaptic vesicle retrieval.. Elife, 8 [PMID:31074746]
5. Junghans V et al.. (2020) Effects of a local auxiliary protein on the two-dimensional affinity of a TCR-peptide MHC interaction.. J Cell Sci, 133 (15): [PMID:32591485]
6. Li B et al.. (2021) Evaluating sources of technical variability in the mechano-node-pore sensing pipeline and their effect on the reproducibility of single-cell mechanical phenotyping.. PLoS One, 16 (10): (e0258982). [PMID:34695165]
7. Baschieri F et al.. (2018) Frustrated endocytosis controls contractility-independent mechanotransduction at clathrin-coated structures.. Nat Commun, 9 (3825). [PMID:30237420]
8. Gu X et al.. (2021) Glucocorticoids Promote Extracellular Matrix Component Remodeling by Activating YAP in Human Retinal Capillary Endothelial Cells.. Front Cell Dev Biol, 9 (738341). [PMID:34970541]
9. Kasioulis I et al.. (2017) Inter-dependent apical microtubule and actin dynamics orchestrate centrosome retention and neuronal delamination.. Elife, 6 [PMID:29058679]
10. Li B et al.. (2022) Mechanical phenotyping reveals unique biomechanical responses in retinoic acid-resistant acute promyelocytic leukemia.. iScience, 25 (2): (103772). [PMID:35141508]
11. Park JS et al.. (2020) Mechanical regulation of glycolysis via cytoskeleton architecture.. Nature, 578 (7796): (621-626). [PMID:32051585]
12. Lin WF et al.. (2018) Pseudopod-associated protein KIF20B promotes Gli1-induced epithelial-mesenchymal transition modulated by pseudopodial actin dynamic in human colorectal cancer.. Mol Carcinog, 57 (7): (911-925). [PMID:29573464]
13. Bakalar MH et al.. (2018) Size-Dependent Segregation Controls Macrophage Phagocytosis of Antibody-Opsonized Targets.. Cell, 174 (131-142.e13). [PMID:29958103]
14. Lim Y et al.. (2021) ß2-adrenergic receptor regulates ER-mitochondria contacts.. Sci Rep, 11 (21477). [PMID:34728663]
15. Wang G et al.. (2019) Structural plasticity of actin-spectrin membrane skeleton and functional role of actin and spectrin in axon degeneration.. Elife, 8 [PMID:31042147]
16. Priti A et al.. (2018) Syncytial germline architecture is actively maintained by contraction of an internal actomyosin corset.. Nat Commun, 9 (4694). [PMID:30410005]
17. Mund M et al.. (2018) Systematic Nanoscale Analysis of Endocytosis Links Efficient Vesicle Formation to Patterned Actin Nucleation.. Cell, 174 (4): (884-896.e17). [PMID:30057119]
18. de Los Ángeles Juricic Urzúa M et al.. (2022) The dendritic ERGIC: Microtubule and actin cytoskeletons participate in stop-and-go movement of mobile carriers between stable structures.. Traffic, 23 (3): (174-187). [PMID:35075729]

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Latrunculin A (LAT-A) - 93%, high purity , CAS No.76343-93-6

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

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References

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