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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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L412411-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $112.90 | |
L412411-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $229.90 | |
L412411-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $417.90 | |
L412411-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,988.90 | |
L412411-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $937.90 |
Specifications & Purity | Moligand™, ≥97% |
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Biochemical and Physiological Mechanisms | LAU159 is a potent functionally selective positive modulator of α1β3\xa0GABA(A)\xa0receptor with\xa0EC50\xa0of 2.2 μM. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | ALLOSTERIC MODULATOR |
Mechanism of action | Allosteric modulator of GABA A receptor α6 subunit |
Product Description | Information LAU159 is a potent functionally selective positive modulator of α1β3 GABA(A) receptor with EC50 of 2.2 μM. |
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IUPAC Name | 8-chloro-2-(3-methoxyphenyl)-1H-pyrazolo[4,3-c]quinolin-3-one |
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INCHI | InChI=1S/C17H12ClN3O2/c1-23-12-4-2-3-11(8-12)21-17(22)14-9-19-15-6-5-10(18)7-13(15)16(14)20-21/h2-9,20H,1H3 |
InChi Key | PAQDEKQVYZRUSQ-UHFFFAOYSA-N |
Canonical SMILES | COC1=CC=CC(=C1)N2C(=O)C3=CN=C4C=CC(=CC4=C3N2)Cl |
Isomeric SMILES | COC1=CC=CC(=C1)N2C(=O)C3=CN=C4C=CC(=CC4=C3N2)Cl |
PubChem CID | 124111373 |
Molecular Weight | 325.7 |
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1. Treven M, Siebert DCB, Holzinger R, Bampali K, Fabjan J, Varagic Z, Wimmer L, Steudle F, Scholze P, Schnürch M et al.. (2018) Towards functional selectivity for α6β3γ2 GABAA receptors: a series of novel pyrazoloquinolinones.. Br J Pharmacol, 175 (3): (419-428). [PMID:29127702] |