LB42908 , CAS No.226927-89-5, Inhibitor of farnesyltransferase; CAAX box; beta

Item Number
L611463
Grouped product items
SKUSizeAvailabilityPrice Qty
L611463-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$300.90
L611463-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$941.90

Basic Description

SynonymsLB 42908
Specifications & PurityMoligand™
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of farnesyltransferase; CAAX box; beta

Associated Targets(Human)

CYP3A4 Tclin Cytochrome P450 3A4 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
FNTB Tclin Protein farnesyltransferase subunit beta (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 1-(1-{[1-(3a,7a-dihydro-2H-1,3-benzodioxol-5-ylmethyl)-1H-imidazol-5-yl]methyl}-4-(naphthalen-1-yl)-1H-pyrrole-3-carbonyl)-4-methylpiperazine
INCHI InChI=1S/C32H33N5O3/c1-34-11-13-36(14-12-34)32(38)29-20-35(19-28(29)27-8-4-6-24-5-2-3-7-26(24)27)18-25-16-33-21-37(25)17-23-9-10-30-31(15-23)40-22-39-30/h2-10,15-16,19-21,30-31H,11-14,17-18,22H2,1H3
InChi Key VZWZHIJGBPHRDI-UHFFFAOYSA-N
Canonical SMILES CN1CCN(CC1)C(=O)c1cn(cc1c1cccc2c1cccc2)Cc1cncn1CC1=CC2C(C=C1)OCO2
Isomeric SMILES CN1CCN(CC1)C(=O)C2=CN(C=C2C3=CC=CC4=CC=CC=C43)CC5=CN=CN5CC6=CC7C(C=C6)OCO7
PubChem CID 91623355

Certificates

Certificate of Analysis(COA)

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Related Documents

References

1. Lee H, Lee J, Lee S, Shin Y, Jung W, Kim JH, Park K, Kim K, Cho HS, Ro S et al..  (2001)  A novel class of highly potent, selective, and non-peptidic inhibitor of Ras farnesyltransferase (FTase)..  Bioorg Med Chem Lett,  11  (23): (3069-72).  [PMID:11714612] [10.1021/op500134e]
2. Downward J.  (2003)  Targeting RAS signalling pathways in cancer therapy..  Nat Rev Cancer,  (1): (11-22).  [PMID:12509763] [10.1021/op500134e]

Solution Calculators