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LBA , CAS No.L611464, Channel blocker of TRPM4

Item Number

L611464

Grouped product items
SKU	Size	Availability	Price	Qty
L611464-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
L611464-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,001.90

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Basic Description

TRPM4 Tchem Transient receptor potential cation channel subfamily M member 4 (1 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

IUPAC Name	4-chloro-2-[2-(4-chloro-2-methylphenoxy)propanoylamino]benzoic acid
INCHI	InChI=1S/C17H15Cl2NO4/c1-9-7-11(18)4-6-15(9)24-10(2)16(21)20-14-8-12(19)3-5-13(14)17(22)23/h3-8,10H,1-2H3,(H,20,21)(H,22,23)
InChi Key	OSXUWZRUCZLQBD-UHFFFAOYSA-N
Canonical SMILES	CC(OC1=CC=C(Cl)C=C1C)C(=O)NC2=C(C=CC(Cl)=C2)C(O)=O
Isomeric SMILES	CC1=C(C=CC(=C1)Cl)OC(C)C(=O)NC2=C(C=CC(=C2)Cl)C(=O)O
PubChem CID	2950887

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1. Delalande C, Awale M, Rubin M, Probst D, Ozhathil LC, Gertsch J, Abriel H, Reymond JL. (2019) Optimizing TRPM4 inhibitors in the MHFP6 chemical space.. Eur J Med Chem, 166 (13): (167-177). [PMID:30708257] [10.1021/op500134e]
2. Ozhathil LC, Delalande C, Bianchi B, Nemeth G, Kappel S, Thomet U, Ross-Kaschitza D, Simonin C, Rubin M, Gertsch J et al.. (2018) Identification of potent and selective small molecule inhibitors of the cation channel TRPM4.. Br J Pharmacol, 175 (12): (2504-2519). [PMID:29579323] [10.1021/op500134e]

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