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LBM-415 , CAS No.478913-91-6

CAS#: 478913-91-6
PubChem CID: 9690139

Item Number

L611467

Grouped product items
SKU	Size	Availability	Price	Qty
L611467-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$570.90
L611467-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

Basic Description

Synonyms	LBM-415 \| NVP-PDF-713 \| VIC-104959 \| LBM 415 \| 027G8KN47F \| UNII-027G8KN47F \| LBM415 \| (2S)-1-((2R)-2-((Formylhydroxyamino)methyl)hexanoyl)pyrrolidine-2-carboxylic acid N-(5-fluoro-1-oxopyridin-2-yl)amide \| 478913-91-6 \| L-Prolinamide, (2R)-2-butyl-N-formyl-N-hydroxy-beta-
Specifications & Purity	Moligand™
Grade	Moligand™

Associated Targets(non-human)

Streptococcus pneumoniae 31063 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Pseudomonas aeruginosa 123386 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Shigella boydii 323 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Shigella flexneri 1836 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Staphylococcus aureus 210822 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Staphylococcus epidermidis 22802 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Escherichia coli 133304 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Haemophilus influenzae 8812 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Enterococcus faecalis 29875 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mus musculus 284745 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Streptomyces albus 134 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	(2S)-N-(5-fluoro-1-hydroxypyridin-2-ylidene)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]pyrrolidine-2-carboxamide
INCHI	InChI=1S/C18H25FN4O5/c1-2-3-5-13(10-21(27)12-24)18(26)22-9-4-6-15(22)17(25)20-16-8-7-14(19)11-23(16)28/h7-8,11-13,15,27-28H,2-6,9-10H2,1H3/t13-,15+/m1/s1
InChi Key	AYCMYBACERJYNY-HIFRSBDPSA-N
Canonical SMILES	CCCC[C@@H](C(=O)N1CCC[C@H]1C(=O)N=c1ccc(cn1O)F)CN(C=O)O
Isomeric SMILES	CCCC[C@H](CN(C=O)O)C(=O)N1CCC[C@H]1C(=O)N=C2C=CC(=CN2O)F
PubChem CID	9690139

PubChem CID

9690139

CAS Registry No.

478913-91-6

ChEMBL Ligand

CHEMBL221667

Antibiotic DB

670, 671

References

1. Kosowska-Shick K, Credito KL, Pankuch GA, DeWasse B, McGhee P, Appelbaum PC. (2007) Multistep resistance selection and postantibiotic-effect studies of the antipneumococcal activity of LBM415 compared to other agents.. Antimicrob Agents Chemother, 51 (2): (770-3). [PMID:17116666]
2. Anderegg TR, Jones RN, Quality Control Working Group. (2004) Disk diffusion quality control guidelines for NVP-PDF 713: a novel peptide deformylase inhibitor.. Diagn Microbiol Infect Dis, 48 (1): (55-7). [PMID:14761722]
3. Jones RN, Moet GJ, Sader HS, Fritsche TR. (2004) Potential utility of a peptide deformylase inhibitor (NVP PDF-713) against oxazolidinone-resistant or streptogramin-resistant Gram-positive organism isolates.. J Antimicrob Chemother, 53 (5): (804-7). [PMID:15056649]
4. Waites KB, Reddy NB, Crabb DM, Duffy LB. (2005) Comparative in vitro activities of investigational peptide deformylase inhibitor NVP LBM-415 and other agents against human mycoplasmas and ureaplasmas.. Antimicrob Agents Chemother, 49 (6): (2541-2). [PMID:15917568]
5. Sangshetti JN, Khan FA, Shinde DB. (2015) Peptide deformylase: a new target in antibacterial, antimalarial and anticancer drug discovery.. Curr Med Chem, 22 (2): (214-36). [PMID:25174923]

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