LBM-415 , CAS No.478913-91-6

Item Number
L611467
Grouped product items
SKUSizeAvailabilityPrice Qty
L611467-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$570.90
L611467-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,000.90

Basic Description

SynonymsLBM-415 | NVP-PDF-713 | VIC-104959 | LBM 415 | 027G8KN47F | UNII-027G8KN47F | LBM415 | (2S)-1-((2R)-2-((Formylhydroxyamino)methyl)hexanoyl)pyrrolidine-2-carboxylic acid N-(5-fluoro-1-oxopyridin-2-yl)amide | 478913-91-6 | L-Prolinamide, (2R)-2-butyl-N-formyl-N-hydroxy-beta-
Specifications & PurityMoligand™
GradeMoligand™

Associated Targets(non-human)

Streptococcus pneumoniae (31063 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pseudomonas aeruginosa (123386 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Shigella boydii (323 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Shigella flexneri (1836 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus epidermidis (22802 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Escherichia coli (133304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Haemophilus influenzae (8812 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Enterococcus faecalis (29875 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name (2S)-N-(5-fluoro-1-hydroxypyridin-2-ylidene)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]pyrrolidine-2-carboxamide
INCHI InChI=1S/C18H25FN4O5/c1-2-3-5-13(10-21(27)12-24)18(26)22-9-4-6-15(22)17(25)20-16-8-7-14(19)11-23(16)28/h7-8,11-13,15,27-28H,2-6,9-10H2,1H3/t13-,15+/m1/s1
InChi Key AYCMYBACERJYNY-HIFRSBDPSA-N
Canonical SMILES CCCC[C@@H](C(=O)N1CCC[C@H]1C(=O)N=c1ccc(cn1O)F)CN(C=O)O
Isomeric SMILES CCCC[C@H](CN(C=O)O)C(=O)N1CCC[C@H]1C(=O)N=C2C=CC(=CN2O)F
PubChem CID 9690139

Certificates

Certificate of Analysis(COA)

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Related Documents

References

1. Kosowska-Shick K, Credito KL, Pankuch GA, DeWasse B, McGhee P, Appelbaum PC.  (2007)  Multistep resistance selection and postantibiotic-effect studies of the antipneumococcal activity of LBM415 compared to other agents..  Antimicrob Agents Chemother,  51  (2): (770-3).  [PMID:17116666] [10.1021/op500134e]
2. Anderegg TR, Jones RN, Quality Control Working Group.  (2004)  Disk diffusion quality control guidelines for NVP-PDF 713: a novel peptide deformylase inhibitor..  Diagn Microbiol Infect Dis,  48  (1): (55-7).  [PMID:14761722] [10.1021/op500134e]
3. Jones RN, Moet GJ, Sader HS, Fritsche TR.  (2004)  Potential utility of a peptide deformylase inhibitor (NVP PDF-713) against oxazolidinone-resistant or streptogramin-resistant Gram-positive organism isolates..  J Antimicrob Chemother,  53  (5): (804-7).  [PMID:15056649] [10.1021/op500134e]
4. Waites KB, Reddy NB, Crabb DM, Duffy LB.  (2005)  Comparative in vitro activities of investigational peptide deformylase inhibitor NVP LBM-415 and other agents against human mycoplasmas and ureaplasmas..  Antimicrob Agents Chemother,  49  (6): (2541-2).  [PMID:15917568] [10.1021/op500134e]
5. Sangshetti JN, Khan FA, Shinde DB.  (2015)  Peptide deformylase: a new target in antibacterial, antimalarial and anticancer drug discovery..  Curr Med Chem,  22  (2): (214-36).  [PMID:25174923] [10.1021/op500134e]

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