Lck inhibitor 2 - 99%, high purity , CAS No.944795-06-6

Item Number

L648683

• Specifications & Purity: ≥99%
• Biochemical and Physiological Mechanisms: Lck inhibitor 2 is a bis-anilinopyrimidine inhibitor of tyrosine kinases including LCK , BTK , LYN, SYK , and TXK. The IC50 values are 13nM, 9nM, 3nM, 26nM and 2nM for Lck , Btk , Lyn, Btk and Txk respectively \nIC50 Value: 13 nM(Lck) \nTarget: Src fam
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads

Product Description

Lck inhibitor 2 is a bis-anilinopyrimidine inhibitor of tyrosine kinases including LCK, BTK , LYN, SYK , and TXK. The IC50 values are 13nM, 9nM, 3nM, 26nM and 2nM for Lck, Btk , Lyn, Btk and Txk respectivelyIC50 Value: 13 nM(Lck) Target: Src family kinaseLck inhibitor 2(Compound 9) inhibited 48 kinases with %control < 1 (33 of them tyrosine kinases, almost half of the 71 tyrosine kinases in the panel). A further 27 kinases were bound with %control < 10. Kd values for 16 kinases were determined and found to be below 100 nM. These included TXK (10 nM).

Form:Solid