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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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L420283-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $241.90 |
Potent IAP\xa0inhibitor
Synonyms | LCL161 | 1005342-46-0 | LCL-161 | (s)-n-((s)-1-cyclohexyl-2-((s)-2-(4-(4-fluorobenzoyl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)-2-(methylamino)propanamide | LCL 161 | Nvp-lcl 161 | NVP-LCL161 | 6TNS415Y3P | CHEMBL2431768 | (2S)-N-[(1S)-1-cyclohexyl-2-[(2S)-2-[4-(4-fluorob |
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Specifications & Purity | Moligand™, 10mM in DMSO |
Biochemical and Physiological Mechanisms | Description:IC50 Value: N/ALCL161 is an oral small molecule antagonist of Inhibitor of Apoptosis Proteins (IAPs) that sensitizes a subset of tumors from diverse lineages to treatment with cytotoxic therapies.in vitro: Huh-7 cells co-treated with LCL161 an |
Storage Temp | Store at -80°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of baculoviral IAP repeat containing 2;Inhibitor of X-linked inhibitor of apoptosis |
Product Description | LCL161, a SMAC mimetic, potently binds to and inhibits multiple IAPs (i.e. XIAP, c-IAP). Phase 2. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Tyrosine-protein kinase ABL inhibitor | INHIBITOR | ALA1862 | Tyrosine-protein kinase ABL | SINGLE PROTEIN | Homo sapiens | DailyMed: [1] | |
Tyrosine-protein kinase ABL inhibitor | INHIBITOR | ALA1862 | Tyrosine-protein kinase ABL | SINGLE PROTEIN | Homo sapiens | DailyMed: [1] | |
Tyrosine-protein kinase ABL inhibitor | INHIBITOR | ALA1862 | Tyrosine-protein kinase ABL | SINGLE PROTEIN | Homo sapiens | Expert: [1] | |
Tyrosine-protein kinase ABL inhibitor | INHIBITOR | ALA1862 | Tyrosine-protein kinase ABL | SINGLE PROTEIN | Homo sapiens | ||
Tyrosine-protein kinase ABL inhibitor | INHIBITOR | ALA1862 | Tyrosine-protein kinase ABL | SINGLE PROTEIN | Homo sapiens | ||
Tyrosine-protein kinase ABL inhibitor | INHIBITOR | ALA1862 | Tyrosine-protein kinase ABL | SINGLE PROTEIN | Homo sapiens | ||
Tyrosine-protein kinase ABL inhibitor | INHIBITOR | ALA1862 | Tyrosine-protein kinase ABL | SINGLE PROTEIN | Homo sapiens | ||
Tyrosine-protein kinase ABL inhibitor | INHIBITOR | ALA1862 | Tyrosine-protein kinase ABL | SINGLE PROTEIN | Homo sapiens | ||
Tyrosine-protein kinase ABL inhibitor | INHIBITOR | ALA1862 | Tyrosine-protein kinase ABL | SINGLE PROTEIN | Homo sapiens | ||
Tyrosine-protein kinase ABL inhibitor | INHIBITOR | ALA1862 | Tyrosine-protein kinase ABL | SINGLE PROTEIN | Homo sapiens | PubMed: [1] |
IUPAC Name | (2S)-N-[(1S)-1-cyclohexyl-2-[(2S)-2-[4-(4-fluorobenzoyl)-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxoethyl]-2-(methylamino)propanamide |
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INCHI | InChI=1S/C26H33FN4O3S/c1-16(28-2)24(33)30-22(17-7-4-3-5-8-17)26(34)31-14-6-9-21(31)25-29-20(15-35-25)23(32)18-10-12-19(27)13-11-18/h10-13,15-17,21-22,28H,3-9,14H2,1-2H3,(H,30,33)/t16-,21-,22-/m0/s1 |
InChi Key | UFPFGVNKHCLJJO-SSKFGXFMSA-N |
Canonical SMILES | CC(C(=O)NC(C1CCCCC1)C(=O)N2CCCC2C3=NC(=CS3)C(=O)C4=CC=C(C=C4)F)NC |
Isomeric SMILES | C[C@@H](C(=O)N[C@@H](C1CCCCC1)C(=O)N2CCC[C@H]2C3=NC(=CS3)C(=O)C4=CC=C(C=C4)F)NC |
PubChem CID | 24737642 |
Molecular Weight | 500.63 |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H302:Harmful if swallowed |
Precautionary Statements | P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help. |