LDN-193189 - ≥98%, high purity , CAS No.1062368-24-4

Item Number

L127229

• Synonyms: 1062368-24-4 | LDN193189 | LDN-193189 | 4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline | LDN 193189 | 4-[6-(4-Piperazin-1-Ylphenyl)pyrazolo[1,5-A]pyrimidin-3-Yl]quinoline | LDN193189 free base | DM-3189 | W69H5YQU9O | CHEMBL513147 | LDN193189 (GMP) | 4-
• Specifications & Purity: ≥98%
• Biochemical and Physiological Mechanisms:

  LDN193189 is a highly potent small molecule BMP inhibitor; inhibiting BMP type I receptors ALK2 (IC50: 5 nM), ALK3 (IC50: 30 nM) and ALK6 (TGFβ1/BMP signaling) and subsequent SMAD phosphorylation; LDN193189 is useful tool in stem cell biol

• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads

Product Description

LDN193189 is a selective BMP signaling inhibitor, inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 of 5 nM and 30 nM, respectively, exhibits 200-fold selectivity for BMP versus TGF-β.