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LDN-57444 - ≥98% (HPLC), high purity , CAS No.668467-91-2

≥98%(HPLC)

CAS#: 668467-91-2
Formula: C₁₇H₁₁Cl₃N₂O₃
Molecular Weight: 397.64
MDL number: MFCD09037562
PubChem CID: 16760696

Item Number

L137664

Grouped product items
SKU	Size	Availability	Price
L137664-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$69.90
L137664-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$315.90
L137664-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$616.90

Reversible, competitive UCH-L1 inhibitor

Basic Description

Synonyms	LDN-57444 \| 668467-91-2 \| CID 16760696 \| CHEMBL3407553 \| (Z)-3-(acetoxyimino)-5-chloro-1-(2,5-dichlorobenzyl)indolin-2-one \| LDN 57444 \| [(Z)-[5-chloro-1-[(2,5-dichlorophenyl)methyl]-2-oxoindol-3-ylidene]amino] acetate \| LDN57444 \| 5-Chloro-1-[(2,5-dichlorophenyl)methyl]
Specifications & Purity	≥98% (HPLC)
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Product Description	LDN-57444 is a reversible, competitive proteasome inhibitor for Uch-L1 with IC50 of 0.88 μM, 28-fold selectivity over isoform Uch-L3. A potent, reversible, active site-directed UCH-L1 inhibitor

Associated Targets(Human)

UCHL1 Tchem Ubiquitin carboxyl-terminal hydrolase isozyme L1 (1 Activities)

Discover Target: UCHL1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

UCHL1 Tchem Ubiquitin carboxyl-terminal hydrolase isozyme L1 (107 Activities)

Discover Target: UCHL1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	[(Z)-[5-chloro-1-[(2,5-dichlorophenyl)methyl]-2-oxoindol-3-ylidene]amino] acetate
INCHI	InChI=1S/C17H11Cl3N2O3/c1-9(23)25-21-16-13-7-12(19)3-5-15(13)22(17(16)24)8-10-6-11(18)2-4-14(10)20/h2-7H,8H2,1H3/b21-16-
InChi Key	OPQRFPHLZZPCCH-PGMHBOJBSA-N
Canonical SMILES	CC(=O)ON=C1C2=C(C=CC(=C2)Cl)N(C1=O)CC3=C(C=CC(=C3)Cl)Cl
Isomeric SMILES	CC(=O)O/N=C\1/C2=C(C=CC(=C2)Cl)N(C1=O)CC3=C(C=CC(=C3)Cl)Cl
WGK Germany	3
PubChem CID	16760696
Molecular Weight	397.64

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2 results found

Lot Number	Certificate Type	Date	Item
E1708073	Certificate of Analysis	Sep 12, 2024	L137664
L2321295	Certificate of Analysis	Jan 03, 2024	L137664

Pictogram(s)

GHS09

Signal

Warning

Hazard Statements

H400:Very toxic to aquatic life

H410:Very toxic to aquatic life with long lasting effects

Precautionary Statements

P273:Avoid release to the environment.

P501:Dispose of contents/container to ...

P391:Collect spillage.

WGK Germany

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LDN-57444 - ≥98% (HPLC), high purity , CAS No.668467-91-2

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

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