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Leflunomide - ≥98%, high purity , Dihydroorotate dehydrogenase inhibitor, CAS No.75706-12-6, Dihydroorotate dehydrogenase inhibitor

  • Moligand™
  • ≥98%
Item Number
L129518
Grouped product items
SKUSizeAvailabilityPrice Qty
L129518-50mg
50mg
In stock
$15.90
L129518-200mg
200mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$24.90
L129518-250mg
250mg
In stock
$44.90
L129518-1g
1g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$136.90
L129518-5g
5g
In stock
$615.90
L129518-25g
25g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,770.90
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Immunomodulatory agent

View related series
dihydroorotate dehydrogenase (quinone) Inhibitor

Basic Description

Synonymsleflunomide|75706-12-6|Arava|lefunamide|Leflunomida|Leflunomidum|Repso|leflunomide medac|5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide|HWA 486|HWA-486|Leflunomidum [INN-Latin]|SU101|SU 101 (pharmaceutical)|Leflunomide teva|5-methyl-N-(4
Specifications & Purity≥98%
Storage TempStore at 2-8°C
Shipped InWet ice
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionDihydroorotate dehydrogenase inhibitor
Product Description

Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD, used as an immunosuppressant agent.
An inhibitor of Cox-2 and tyrosine kinase.

Product Properties

ALogP2.5

Associated Targets

CYP1A2 Tchem Cytochrome P450 1A2 2 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

DHODH Tclin Dihydroorotate dehydrogenase (quinone), mitochondrial 2 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide
INCHI InChI=1S/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13,14)15/h2-6H,1H3,(H,17,18)
InChi Key VHOGYURTWQBHIL-UHFFFAOYSA-N
Canonical SMILES CC1=C(C=NO1)C(=O)NC2=CC=C(C=C2)C(F)(F)F
Isomeric SMILES CC1=C(C=NO1)C(=O)NC2=CC=C(C=C2)C(F)(F)F
WGK Germany 3
RTECS NY2354200
PubChem CID 3899
Molecular Weight 270.21
Reaxy-Rn 4323174

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

5 results found

Lot NumberCertificate TypeDateItem
K2117349Certificate of AnalysisSep 14, 2023 L129518
K2117350Certificate of AnalysisSep 14, 2023 L129518
K2117351Certificate of AnalysisSep 14, 2023 L129518
A2306195Certificate of AnalysisJan 29, 2023 L129518
H2304227Certificate of AnalysisNov 22, 2021 L129518

Chemical and Physical Properties

SolubilitySoluble in DMSO (54 mg/ml at 25 °C), ethanol (54 mg/ml at 25 °C), and water (<1 mg/ml at 25 °C).
SensitivityHeat sensitive
Melt Point(°C)166.5°C

Safety and Hazards(GHS)

Pictogram(s) GHS06,   GHS07
Signal Danger
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

H301:Toxic if swallowed

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P270:Do not eat, drink or smoke when using this product.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P330:Rinse mouth.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P301+P316:IF SWALLOWED: Get emergency medical help immediately.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

WGK Germany 3
RTECS NY2354200
Reaxy-Rn 4323174
Merck Index 5432

Related Documents

 SDS

 Specification Sheet

References

1. Munier-Lehmann H, Vidalain PO, Tangy F, Janin YL.  (2013)  On dihydroorotate dehydrogenases and their inhibitors and uses..  J Med Chem,  56  (8): (3148-67).  [PMID:23452331]

Solution Calculators

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