LEI105 , CAS No.L611477, Inhibitor of Diacylglycerol lipase α;Inhibitor of Diacylglycerol lipase β

Item Number

L611477

Grouped product items
SKU	Size	Availability	Price	Qty
L611477-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$922.90
L611477-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$3,200.90

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Synonyms

LEI-105

Specifications & Purity

Moligand™

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Inhibitor of Diacylglycerol lipase α;Inhibitor of Diacylglycerol lipase β

Associated Targets(Human)

DAGLB Tchem Sn1-specific diacylglycerol lipase beta (1 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DAGLA Tchem Sn1-specific diacylglycerol lipase alpha (4 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	1-[6-(4-methylphenyl)-[1,3]oxazolo[4,5-b]pyridin-2-yl]-6-phenylhexan-1-one
INCHI	InChI=1S/C25H24N2O2/c1-18-12-14-20(15-13-18)21-16-23-24(26-17-21)27-25(29-23)22(28)11-7-3-6-10-19-8-4-2-5-9-19/h2,4-5,8-9,12-17H,3,6-7,10-11H2,1H3
InChi Key	XDHONXIOZAUYDB-UHFFFAOYSA-N
Canonical SMILES	Cc1ccc(cc1)c1cnc2c(c1)oc(n2)C(=O)CCCCCc1ccccc1
Isomeric SMILES	CC1=CC=C(C=C1)C2=CC3=C(N=C2)N=C(O3)C(=O)CCCCCC4=CC=CC=C4
PubChem CID	122390213

References

1. Baggelaar MP, Chameau PJ, Kantae V, Hummel J, Hsu KL, Janssen F, van der Wel T, Soethoudt M, Deng H, den Dulk H et al.. (2015) Highly Selective, Reversible Inhibitor Identified by Comparative Chemoproteomics Modulates Diacylglycerol Lipase Activity in Neurons.. J Am Chem Soc, 137 (27): (8851-7). [PMID:26083464] [10.1021/op500134e]

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Basic Description