lenvatinib Mesylate - 99%, high purity , Vascular endothelial growth factor receptor inhibitor, CAS No.857890-39-2, Vascular endothelial growth factor receptor inhibitor

Item Number

M304782

Grouped product items
SKU	Size	Availability	Price
M304782-250mg	250mg	In stock	$92.90
M304782-1g	1g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$259.90
M304782-5g	5g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$899.90

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Basic Description

Synonyms	DTXCID90157572 \| CCG-269873 \| CS-0030963 \| 3-(2-aminoethyl) pyridine \| AC-30100 \| BCP11858 \| DS-19245 \| SB16581 \| 6-carbamoyl-4-(3-chloro-4-((cyclopropylcarbamoyl)amino)phenoxy)-7-methoxyquinolin-1-ium methanesulfonate \| 4-[3-Chloro-4-[[(cyclopropylamino)
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	Lenvatinib (E7080) is an orally active inhibitor against multiple receptor tyrosine kinases, including VEGFR (Flt-1/KDR/Flt-4 IC50 = 22/4.0/5.2 nM), PDGFR1/2 (IC50 = 39/51 nM), FGFR1 and KIT (IC50 = 46 and 100 nM, respectively) that inhibits angiogenesis
Storage Temp	Store at 2-8°C,Protected from light,Desiccated
Shipped In	Wet ice
Action Type	INHIBITOR
Mechanism of action	Vascular endothelial growth factor receptor inhibitor

Names and Identifiers

IUPAC Name	4-[3-chloro-4-(cyclopropylcarbamoylamino)phenoxy]-7-methoxyquinoline-6-carboxamide;methanesulfonic acid
INCHI	InChI=1S/C21H19ClN4O4.CH4O3S/c1-29-19-10-17-13(9-14(19)20(23)27)18(6-7-24-17)30-12-4-5-16(15(22)8-12)26-21(28)25-11-2-3-11;1-5(2,3)4/h4-11H,2-3H2,1H3,(H2,23,27)(H2,25,26,28);1H3,(H,2,3,4)
InChi Key	HWLFIUUAYLEFCT-UHFFFAOYSA-N
Canonical SMILES	COC1=CC2=NC=CC(=C2C=C1C(=O)N)OC3=CC(=C(C=C3)NC(=O)NC4CC4)Cl.CS(=O)(=O)O
Isomeric SMILES	COC1=CC2=NC=CC(=C2C=C1C(=O)N)OC3=CC(=C(C=C3)NC(=O)NC4CC4)Cl.CS(=O)(=O)O
Alternate CAS	857890-39-2
PubChem CID	11237762
MeSH Entry Terms	4-(3-chloro-4-(((cyclopropylamino)carbonyl)amino)phenoxy)-7-hydroxy-6-quinolinecarboxamide;4-(3-chloro-4-((cyclopropylaminocarbonyl)amino)phenoxy)-7-methoxy-6-quinolinecarboxamide;4-(3-chloro-4-(N'-cyclopropylureido)phenoxy)-7-methoxyquinoline-6-carboxami
Molecular Weight	522.96

Certificates

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3 results found

Lot Number	Certificate Type	Date	Item
J2112614	Certificate of Analysis	Aug 14, 2024	M304782
K2322097	Certificate of Analysis	May 21, 2021	M304782
L2301109	Certificate of Analysis	May 21, 2021	M304782

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Danger
Hazard Statements	H302:Harmful if swallowed H372:Causes damage to organs through prolonged or repeated exposure H361:Suspected of damaging fertility or the unborn child H362:May cause harm to breast-fed children
Precautionary Statements	P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P263:Avoid contact during pregnancy/while nursing. P203:Obtain, read and follow all safety instructions before use. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P319:Get medical help if you feel unwell.

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Basic Description