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Leptomycin B - 98%, high purity , CAS No.87081-35-4

≥98%

CAS#: 87081-35-4
Formula: C₃₃H₄₈O₆
Molecular Weight: 540.73
MDL number: MFCD06795848
PubChem CID: 6917907

Item Number

L102387

Grouped product items
SKU	Size	Availability	Price	Qty
L102387-1mg	1mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$256.90
L102387-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,744.90

Discover Leptomycin B by Aladdin Scientific in 98% for only $256.90. Available - in Ligands at Aladdin Scientific. Antibiotic, antifungal. Inhibitor of CRM-1 mediated nuclear export. Tags: .

Basic Description

Synonyms	Leptomycin B\|Elactocin\|Mantuamycin\|87081-35-4\|Antibiotic CI 940\|Antibiotic CL 1957A\|CI-940\|LEPTOMYCIN B FROM STREPTOMYCES SP\|CHEBI:52646\|PD 114720\|antibiotic ATS 1287B\|Antibiotic PD 114720\|Y031I2N1EO\|ATS 1287B\|CL-1957A\|NSC-364372\|LMB\|PD-114720\|(2E,5S,6R,7
Specifications & Purity	98%
Storage Temp	Protected from light,Store at -20°C,Argon charged
Shipped In	Dry ice
Product Description	Leptomycin B is an anti-fungal antibiotic, anti-tumor cytotoxin that inhibits CRM1-dependent, NES-dependent nucleo-cytoplasmic translocation (nuclear export inhibitor). NES containing proteins include HIV-1 REV; actin, c-Abl, cyclin B1, MDM2/p53, IB, MPF, PKA and MEK. Leptomycin B is a potent and specific nuclear export inhibitor. Leptomycin B alkylates and inhibits CRM1 (chromosomal region maintenance)/exportin 1, a protein required for nuclear export of proteins containing a nuclear export sequence (NES). In addition to antifungal and antibacterial activities, Leptomycin B blocks the cell cycle and is a potent anti-tumor agent. At low nM concentrations, Leptomycin B blocks the nuclear export of many proteins including HIV-1 Rev, MAPK/ERK, and NF-κB/IκB, and it stabilizes the expression of p53. Leptomycin B also inhibits the export and translation of many RNAs, including COX-2 and c-Fos mRNAs, by inhibiting export of ribonucleoproteins.

Associated Targets

XPO1 Tclin Exportin-1 2 Activities

Discover Target: XPO1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-19-[(2S,3S)-3-methyl-6-oxo-2,3-dihydropyran-2-yl]-8-oxononadeca-2,10,12,16,18-pentaenoic acid
INCHI	InChI=1S/C33H48O6/c1-9-28(14-15-29-24(5)13-16-31(36)39-29)19-22(3)12-10-11-21(2)17-25(6)32(37)27(8)33(38)26(7)18-23(4)20-30(34)35/h10-11,13-17,19-20,22,24-27,29,33,38H,9,12,18H2,1-8H3,(H,34,35)/b11-10+,15-14+,21-17+,23-20+,28-19-/t22-,24+,25-,26+,27-,29+,33-/m1/s1
InChi Key	YACHGFWEQXFSBS-XYERBDPFSA-N
Canonical SMILES	CCC(=CC(C)CC=CC(=CC(C)C(=O)C(C)C(C(C)CC(=CC(=O)O)C)O)C)C=CC1C(C=CC(=O)O1)C
Isomeric SMILES	CC/C(=C/[C@H](C)C/C=C/C(=C/[C@@H](C)C(=O)[C@@H](C)[C@@H]([C@@H](C)C/C(=C/C(=O)O)/C)O)/C)/C=C/[C@H]1[C@H](C=CC(=O)O1)C
WGK Germany	1
PubChem CID	6917907
UN Number	1230
Molecular Weight	540.73

Certificates

Certificate of Analysis(COA)

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Lot Number	Certificate Type	Date	Item
L2206349	Certificate of Analysis	Nov 04, 2022	L102387

Chemical and Physical Properties

Solubility	Soluble in ethanol or methanol. Ethanol is recommended. Unstable in DMSO
Sensitivity	Moisture sensitive,Light sensitive
Flash Point(°F)	64.4 °F
Flash Point(°C)	18 °C

Safety and Hazards(GHS)

WGK Germany	1

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