Potent JAK2, FLT3 and TrkA receptor tyrosine kinase inhibitor (IC 50 values are 0.9, 3 and 25 nM respectively). Antiproliferative effects in vitro . Antileukemic agent in vivo . Orally active.
Storage Temp
Protected from light,Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Tyrosine-protein kinase receptor RET inhibitor
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
1.Levis M, Allebach J, Tse KF, Zheng R, Baldwin BR, Smith BD, Jones-Bolin S, Ruggeri B, Dionne C, Small D. (2002) A FLT3-targeted tyrosine kinase inhibitor is cytotoxic to leukemia cells in vitro and in vivo.. Blood, 99 (11):(3885-91). [PMID:12010785]
2.Vazquez-Ortiz G, Chisholm C, Xu X, Lahusen TJ, Li C, Sakamuru S, Huang R, Thomas CJ, Xia M, Deng C. (2014) Drug repurposing screen identifies lestaurtinib amplifies the ability of the poly (ADP-ribose) polymerase 1 inhibitor AG14361 to kill breast cancer associated gene-1 mutant and wild type breast cancer cells.. Breast Cancer Res, 16 (3):(R67). [PMID:24962108]
3.Lee M & Rhee I. (2017) Cytokine Signaling in Tumor Progression.. Immune Netw, 17 (4):(214-227). [PMID:28860951]
4.Chang J et al.. (2018) Exome-wide analysis identifies three low-frequency missense variants associated with pancreatic cancer risk in Chinese populations.. Nat Commun, 9 (3688). [PMID:30206226]
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