Letrozole - 98%, high purity , Cytochrome P450 19A1 inhibitor, CAS No.112809-51-5, Cytochrome P450 19A1 inhibitor

Item Number

L129473

• Synonyms: 4,4'-(1H-1,2,4-Triazol-1-ylmethylene)bisbenzonitrile | Letrozole- Bio-X | Femera | NCGC00016973-06 | LETROZOLE [JAN] | DTXSID4023202 | HMS3651K05 | letrozole | C17H11N5 | SMR000466343 | STL451047 | BCP9000848 | DB01006 | Prestwick1_001025 | SPBio_003070 |
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: Letrozole acts as an adjuvant agent and is used to treat breast cancer. Letrozole is a third generation nonsteroidal aromatase inhibitor. It is a competitive inhibitor of the aromatase enzyme system and thus inhibits the conversion of androgens to estroge
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Cytochrome P450 19A1 inhibitor
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

Letrozole has been used:

· in organoid growth assay to determine its inhibitory capacity(48)

·  to investigate steroid receptor coactivator-1 (SRC-1) mediated endogenous estrogen regulation of hippocampal PSD-95(49)

·  to determine its effects on tumor-induced hyperalgesia(50)

·  for hormonal manipulation in rats(51)

·  to study its effects on lipocalin-2 (Lcn2)(52)

·  to determine its effects on mechanical hyperalgesia and aromatase expression(53)