Leukotriene D4 - 97%，100 ug/mL in ethanol, high purity , CAS No.73836-78-9(Ethanol), Agonist of CysLT 1 receptor;Agonist of CysLT 2 receptor;Agonist of GPR17

Item Number

L275075

• Synonyms: leukotriene D4|73836-78-9|Leukotriene D|LTD4|LTD4 (Leukotriene D4)|5S-hydroxy-6R-(S-cysteinylglycinyl)-7E,9E,11E,14Z-eicosatetraenoic acid|5FNY4416UE|CHEMBL288943|CHEBI:28666|(5S,6R,7E,9E,11Z,14Z)-6-[(2R)-2-amino-3-(carboxymethylamino)-3-oxopropyl]sulfany
• Specifications & Purity: Moligand™, ≥97%, 100 ug/mL in ethanol
• Biochemical and Physiological Mechanisms: Potent, selective CysLT 1 and CysLT 2 receptor agonist (EC 50 values are 1.12 and 0.99 nM, respectively. Induces bronchoconstriction and vasoconstriction. Active in vivo and in vitro .
• Storage Temp: Protected from light,Argon charged,Store at -80°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: AGONIST
• Mechanism of action: Agonist of CysLT 1 receptor;Agonist of CysLT 2 receptor;Agonist of GPR17
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -80°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

Leukotriene D4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase. Leukotriene D4 is the first cysteinyl-leukotriene metabolite of LTC4. Leukotriene D4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute hypersensitivity.