Levocetirizine dihydrochloride - ≥98% (HPLC), high purity , Histamine H1 receptor antagonist, CAS No.130018-87-0, Histamine H1 receptor antagonist

  • ≥98%(HPLC)
Item Number
L124802
Grouped product items
SKUSizeAvailabilityPrice Qty
L124802-1g
1g
In stock
$67.90
L124802-5g
5g
In stock
$217.90
L124802-25g
25g
In stock
$978.90
L124802-100g
100g
In stock
$3,524.90

Potent and selective H 1 receptor antagonist

Basic Description

Synonyms(R)-2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetic acid dihydrochloride | good sense levocetirizine | LEVOCETIRIZINE HYDROCHLORIDE [JAN] | SCHEMBL1435906 | UCB 28556 | Childrens Xyzal Allergy | Levocetirizine (dihydrochloride) | Levo
Specifications & Purity≥98%(HPLC)
Biochemical and Physiological MechanismsLevocetirizine hydrochloride is a nonsedating antihistamine. It is a histamine H1-receptor antagonist, the active isomer of cetirizine. Levocetirizine has high bioavailability, high affinity for and occupancy of the H1 receptor.Potent and selective H 1 re
Shipped InNormal
Action TypeANTAGONIST
Mechanism of actionHistamine H1 receptor antagonist
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets(Human)

HRH1 Tclin Histamine H1 receptor (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
HRH1 Tclin Histamine H1 receptor (7573 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Homo sapiens (32628 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Cavia porcellus (23802 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Canis familiaris (36305 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

Pubchem Sid488196469
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488196469
IUPAC Name 2-[2-[4-[(R)-(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]acetic acid;dihydrochloride
INCHI InChI=1S/C21H25ClN2O3.2ClH/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26;;/h1-9,21H,10-16H2,(H,25,26);2*1H/t21-;;/m1../s1
InChi Key PGLIUCLTXOYQMV-GHVWMZMZSA-N
Canonical SMILES C1CN(CCN1CCOCC(=O)O)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl.Cl.Cl
Isomeric SMILES C1CN(CCN1CCOCC(=O)O)[C@H](C2=CC=CC=C2)C3=CC=C(C=C3)Cl.Cl.Cl
WGK Germany 3
PubChem CID 9955977
Molecular Weight 461.81

Certificates

Certificate of Analysis(COA)

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8 results found

Lot NumberCertificate TypeDateItem
G1516061Certificate of AnalysisMar 07, 2023 L124802
D2318143Certificate of AnalysisJul 22, 2022 L124802
D2318147Certificate of AnalysisJul 22, 2022 L124802
D2318160Certificate of AnalysisJul 22, 2022 L124802
K2230582Certificate of AnalysisJul 22, 2022 L124802
K2230709Certificate of AnalysisJul 22, 2022 L124802
K2230721Certificate of AnalysisJul 22, 2022 L124802
K2230729Certificate of AnalysisJul 22, 2022 L124802

Chemical and Physical Properties

SolubilitySolubility in water: Completely soluble; Degree of Solubility in water: 946 g/l; Insoluble in Acetone
Melt Point(°C)214 °C

Safety and Hazards(GHS)

Pictogram(s) GHS09,   GHS07
Signal Warning
Hazard Statements

H302:Harmful if swallowed

H400:Very toxic to aquatic life

Precautionary Statements

P273:Avoid release to the environment.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P270:Do not eat, drink or smoke when using this product.

P391:Collect spillage.

P330:Rinse mouth.

P301+P317:IF SWALLOWED: Get medical help.

WGK Germany 3
Merck Index 2022

Related Documents

Solution Calculators