Levosimendan - ≥98%, high purity , Troponin, cardiac muscle positive modulator, CAS No.141505-33-1, Troponin, cardiac muscle positive modulator

Item Number

L129925

Grouped product items
SKU	Size	Availability	Price
L129925-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$45.90
L129925-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$75.90
L129925-250mg	250mg	In stock	$171.90
L129925-500mg	500mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$312.90
L129925-1g	1g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$563.90

Potent phosphodiesterase inhibitor

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Basic Description

Synonyms	LEVOSIMENDAN\|141505-33-1\|Simdax\|(R)-Simendan\|(-)-OR-1259\|OR-1259\|Simendan, (r)-\|CHEBI:50567\|NSC-759644\|2-[[4-[(4R)-4-methyl-6-oxo-4,5-dihydro-1H-pyridazin-3-yl]phenyl]hydrazinylidene]propanedinitrile\|Levosimedan\|DTXSID9046445\|C6T4514L4E\|OR1259\|(R)-((4-(1,
Specifications & Purity	≥98%
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Action Type	INHIBITOR
Mechanism of action	Troponin, cardiac muscle positive modulator
Product Description	Levosimendan is a calcium sensitizer acting through calcium-dependent binding to cardiac troponin C (cTnC), provides treatment for heart failure. A Ca2+ sensitizer that increases contractile force of the myocardium.

Names and Identifiers

IUPAC Name	2-[[4-[(4R)-4-methyl-6-oxo-4,5-dihydro-1H-pyridazin-3-yl]phenyl]hydrazinylidene]propanedinitrile
INCHI	InChI=1S/C14H12N6O/c1-9-6-13(21)19-20-14(9)10-2-4-11(5-3-10)17-18-12(7-15)8-16/h2-5,9,17H,6H2,1H3,(H,19,21)/t9-/m1/s1
InChi Key	WHXMKTBCFHIYNQ-SECBINFHSA-N
Canonical SMILES	CC1CC(=O)NN=C1C2=CC=C(C=C2)NN=C(C#N)C#N
Isomeric SMILES	C[C@@H]1CC(=O)NN=C1C2=CC=C(C=C2)NN=C(C#N)C#N
WGK Germany	3
RTECS	TY1570210
PubChem CID	3033825
Molecular Weight	280.28

Certificates

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2 results found

Lot Number	Certificate Type	Date	Item
K2123544	Certificate of Analysis	Sep 19, 2023	L129925
L1525030	Certificate of Analysis	May 12, 2023	L129925

Solubility

Soluble in water (<1 mg/ml), DMSO (56 mg/ml), methanol, and ethanol (<1 mg/ml).

Specific Rotation[α]

-627° (C=0.5,THF)

Melt Point(°C)

210-214°C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed H312:Harmful in contact with skin H332:Harmful if inhaled
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help. P317:Get emergency medical help.
WGK Germany	3
RTECS	TY1570210
Merck Index	5471

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Basic Description