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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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L286924-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $395.90 | |
L286924-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $395.90 | |
L286924-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $622.90 | |
L286924-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,401.90 | |
L286924-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,553.90 | |
L286924-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $2,797.90 |
RXR:PPAR agonist
Synonyms | 180713-37-5 | LG100754 | LG 100754 | CD 3159 | (2e,4e,6z)-3-Methyl-7-(5,5,8,8-Tetramethyl-3-Propoxy-5,6,7,8-Tetrahydronaphthalen-2-Yl)octa-2,4,6-Trienoic Acid | CHEMBL109581 | (2E,4E,6Z)-3-Methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-3-naphthalenyl)-2,4 |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | LG100754 is a unique RXR ligand that acts as an antagonist against RXR homodimers, but is a strong agonist for RXR:PPARα and RXR:PPARγ heterodimers. The compound does not have agonist activities for other RXR heterodimers containing LXR or GAR/FXR recepto |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | AGONIST, ANTAGONIST |
Mechanism of action | Agonist of Peroxisome proliferator-activated receptor-γ;Antagonist of Retinoid X receptor-α;Antagonist of Retinoid X receptor-β;Antagonist of Retinoid X receptor-γ |
Product Description | Application: LG100754 (UVI 2112) is a modulator of RXR dimers. LG100754 acts as an antagonist of the homodimeric RXR:RXR, but as an agonist of the heterodimeric RXR:PPARα and RXR:PPARγ. LG100754 is an insulin sensitizer acting through RXR. |
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IUPAC Name | (2E,4E,6Z)-3-methyl-7-(5,5,8,8-tetramethyl-3-propoxy-6,7-dihydronaphthalen-2-yl)octa-2,4,6-trienoic acid |
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INCHI | InChI=1S/C26H36O3/c1-8-14-29-23-17-22-21(25(4,5)12-13-26(22,6)7)16-20(23)19(3)11-9-10-18(2)15-24(27)28/h9-11,15-17H,8,12-14H2,1-7H3,(H,27,28)/b10-9+,18-15+,19-11- |
InChi Key | HNODNXQAYXJFMQ-LQUSFLDPSA-N |
Canonical SMILES | CCCOC1=CC2=C(C=C1C(=CC=CC(=CC(=O)O)C)C)C(CCC2(C)C)(C)C |
Isomeric SMILES | CCCOC1=CC2=C(C=C1/C(=C\C=C\C(=C\C(=O)O)\C)/C)C(CCC2(C)C)(C)C |
PubChem CID | 6442223 |
Molecular Weight | 396.56 |
PubChem CID | 6442223 |
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ChEMBL Ligand | CHEMBL109581 |
BindingDB Ligand | 50052589 |
CAS Registry No. | 180713-37-5 |
RCSB PDB Ligand | 754 |
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Solubility | Solvent:DMSO, Max Conc. mg/mL: 39.66, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 19.83, Max Conc. mM: 50 |
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