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Licofelone - ≥98%, high purity , CAS No.156897-06-2
Basic Description
| Synonyms | Licofelone | 156897-06-2 | ML-3000 | Licofelone [INN] | ML 3000 | 2-[2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-5,7-dihydropyrrolizin-3-yl]acetic acid | P5T6BYS22Y | (6-(4-Chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)acetic acid | [6-(4-CHLOROPHENYL)- |
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| Specifications & Purity | ≥98% |
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| Biochemical and Physiological Mechanisms | Licofelone is an anti-inflammatory and dual inhibitor of cyclooxygenase and 5-LO(5-lipoxygenase). Licofelone inhibits both Cox-1 and Cox-2. |
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| Storage Temp | Store at -20°C |
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| Shipped In | Ice chest + Ice pads |
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| Note | 卖完停产，不再备货 |
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| Product Description | Licofelone is a dual COX/LOX inhibitor being considered as a treatment for osteoarthritis
An inhibitor of Cox-1, Cox-2, and 5-lipoxygenase. |
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Associated Targets(Human)
Associated Targets(non-human)
Names and Identifiers
| Pubchem Sid | 488187815 |
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| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488187815 |
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| IUPAC Name | 2-[2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-5,7-dihydropyrrolizin-3-yl]acetic acid |
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| INCHI | InChI=1S/C23H22ClNO2/c1-23(2)13-19-22(15-6-4-3-5-7-15)21(16-8-10-17(24)11-9-16)18(12-20(26)27)25(19)14-23/h3-11H,12-14H2,1-2H3,(H,26,27) |
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| InChi Key | UAWXGRJVZSAUSZ-UHFFFAOYSA-N |
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| Canonical SMILES | CC1(CC2=C(C(=C(N2C1)CC(=O)O)C3=CC=C(C=C3)Cl)C4=CC=CC=C4)C |
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| Isomeric SMILES | CC1(CC2=C(C(=C(N2C1)CC(=O)O)C3=CC=C(C=C3)Cl)C4=CC=CC=C4)C |
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| PubChem CID | 133021 |
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| Molecular Weight | 379.88 |
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Chemical and Physical Properties
| Solubility | Soluble in water (0.5 mg/ml at 25 °C), ethanol (~5 mg/ml), DMSO (20 mg/ml), DMF (20 mg/ml), and methanol. |
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| Melt Point(°C) | 165-167°C |
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Safety and Hazards(GHS)
| Pictogram(s) | GHS07 |
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| Signal | Warning |
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| Hazard Statements | H319:Causes serious eye irritation H302:Harmful if swallowed |
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| Precautionary Statements | P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. |
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