Lidocaine hydrochloride - ≥98%, high purity , CAS No.73-78-9

  • ≥98%
Item Number
L276132
Grouped product items
SKUSizeAvailabilityPrice Qty
L276132-1g
1g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$16.90
L276132-5g
5g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$62.90
L276132-10g
10g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$99.90
L276132-25g
25g
In stock
$222.90
L276132-100g
100g
In stock
$710.90

Voltage gated sodium channel blocker

Basic Description

SynonymsRucaina hydrochloride | Xilina hydrochloride | Xyloneural | Lidocaine hydrochloride | Lidothesin | Xycaine hydrochloride | LARYNG-O-JET | Anestacon | Xylocaine Viscous | Duncaine hydrochloride | Lidothesin hydrochloride | Xylotox hydrochloride | LIDOCAINE
Specifications & Purity≥98%
Biochemical and Physiological MechanismsVoltage gated sodium channel blocker (IC 50 values are 42 and 210 μM for TTX-sensitive and TTX-resistant DRG channels respectively). Reduces proinflammatory cytokine production and shows anesthetic effects in vivo.
Storage TempProtected from light,Store at -20°C,Desiccated
Shipped InIce chest + Ice pads
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Lidocaine hydrochloride (Lignocaine hydrochloride) inhibits sodium channels involving complex voltage and using dependence. Lidocaine hydrochloride decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine hydrochloride is an amide derivative and a agent to treat ventricular arrhythmia and an effective tumor-inhibitor.

Associated Targets(Human)

GAA Tclin Lysosomal alpha-glucosidase (35701 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LMNA Tbio Prelamin-A/C (36751 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BLM Tchem Bloom syndrome protein (4248 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Canis familiaris (36305 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Sciatic nerve (18 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapt Microtubule-associated protein tau (6 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide;hydrochloride
INCHI InChI=1S/C14H22N2O.ClH/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4;/h7-9H,5-6,10H2,1-4H3,(H,15,17);1H
InChi Key IYBQHJMYDGVZRY-UHFFFAOYSA-N
Canonical SMILES CCN(CC)CC(=O)NC1=C(C=CC=C1C)C.Cl
Isomeric SMILES CCN(CC)CC(=O)NC1=C(C=CC=C1C)C.Cl
PubChem CID 6314
Molecular Weight 270.8

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

16 results found

Lot NumberCertificate TypeDateItem
L2410509Certificate of AnalysisDec 13, 2024 L276132
H2402016Certificate of AnalysisAug 09, 2024 L276132
C2421038Certificate of AnalysisApr 01, 2024 L276132
F2421069Certificate of AnalysisApr 01, 2024 L276132
C2421489Certificate of AnalysisMar 02, 2024 L276132
C2421490Certificate of AnalysisMar 02, 2024 L276132
C2421491Certificate of AnalysisMar 02, 2024 L276132
C2421492Certificate of AnalysisMar 02, 2024 L276132
K2127605Certificate of AnalysisJun 14, 2023 L276132
H2211325Certificate of AnalysisMay 12, 2023 L276132
H2211328Certificate of AnalysisMay 12, 2023 L276132
H2211329Certificate of AnalysisMay 12, 2023 L276132
J2307026Certificate of AnalysisMay 12, 2023 L276132
K2127609Certificate of AnalysisSep 09, 2022 L276132
D2306120Certificate of AnalysisJun 13, 2022 L276132
E2224202Certificate of AnalysisMay 27, 2022 L276132

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Chemical and Physical Properties

SolubilitySoluble in water to 100 mM
Sensitivitylight & Moisture sensitive

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H302:Harmful if swallowed

Precautionary Statements

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P270:Do not eat, drink or smoke when using this product.

P330:Rinse mouth.

P301+P312:IF SWALLOWED: call a POISON CENTER/doctor/... IF you feel unwell.

Related Documents

Citations of This Product

1. Quanpeng Li, Xueqing Yu, Xiaoyan Zheng, Jing Yang, Junfeng Hui, Daidi Fan.  (2024)  Rapid dissolution microneedle based on polyvinyl alcohol/chitosan for local oral anesthesia.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  257  (128629).  [PMID:38070795] [10.1016/j.ijbiomac.2023.128629]
2. Xiaokang Guan, Qiao Lu, Xiangxu Zhao, Xiaowen Yan, Renato Zenobi.  (2023)  Spatio-Temporal Analysis of Anesthetics in Mice by Solid-Phase Microextraction: Dielectric Barrier Discharge Ionization Mass Spectrometry.  ANALYTICAL CHEMISTRY,  95  (33): (12470–12477).  [PMID:37560898] [10.1021/acs.analchem.3c02123]
3. Wenjie Xu, Yu Xiao, Minzhi Zhao, Jiahui Zhu, Yu Wang, Wenbin Wang, Peng Wang, Huan Meng.  (2023)  Effective Treatment of Knee Osteoarthritis Using a Nano-Enabled Drug Acupuncture Technology in Mice.  Advanced Science,    (2302586).  [PMID:37555294] [10.1002/advs.202302586]
4. Yang Yang, Sun Jiaxiao, Peng Fei, Liu Haibei, Zhao Guoyan, Chen Junjie, Zhang Wensheng, Qiu Feng.  (2022)  Enhanced Antitumor Activity of Lidocaine Nanoparticles Encapsulated by a Self-Assembling Peptide.  Frontiers in Pharmacology,  13    [PMID:35529446] [10.3389/fphar.2022.770892]
5. Baolin Wang, Xing Chen, Zeeshan Ahmad, Jie Huang, Ming-Wei Chang.  (2019)  Engineering On-Demand Magnetic Core–Shell Composite Wound Dressing Matrices via Electrohydrodynamic Micro-Scale Printing.  ADVANCED ENGINEERING MATERIALS,  21  (10): (1900699).  [PMID:] [10.1002/adem.201900699]

References

1. Quanpeng Li, Xueqing Yu, Xiaoyan Zheng, Jing Yang, Junfeng Hui, Daidi Fan.  (2024)  Rapid dissolution microneedle based on polyvinyl alcohol/chitosan for local oral anesthesia.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  257  (128629).  [PMID:38070795] [10.1016/j.ijbiomac.2023.128629]
2. Xiaokang Guan, Qiao Lu, Xiangxu Zhao, Xiaowen Yan, Renato Zenobi.  (2023)  Spatio-Temporal Analysis of Anesthetics in Mice by Solid-Phase Microextraction: Dielectric Barrier Discharge Ionization Mass Spectrometry.  ANALYTICAL CHEMISTRY,  95  (33): (12470–12477).  [PMID:37560898] [10.1021/acs.analchem.3c02123]
3. Wenjie Xu, Yu Xiao, Minzhi Zhao, Jiahui Zhu, Yu Wang, Wenbin Wang, Peng Wang, Huan Meng.  (2023)  Effective Treatment of Knee Osteoarthritis Using a Nano-Enabled Drug Acupuncture Technology in Mice.  Advanced Science,    (2302586).  [PMID:37555294] [10.1002/advs.202302586]
4. Yang Yang, Sun Jiaxiao, Peng Fei, Liu Haibei, Zhao Guoyan, Chen Junjie, Zhang Wensheng, Qiu Feng.  (2022)  Enhanced Antitumor Activity of Lidocaine Nanoparticles Encapsulated by a Self-Assembling Peptide.  Frontiers in Pharmacology,  13    [PMID:35529446] [10.3389/fphar.2022.770892]
5. Baolin Wang, Xing Chen, Zeeshan Ahmad, Jie Huang, Ming-Wei Chang.  (2019)  Engineering On-Demand Magnetic Core–Shell Composite Wound Dressing Matrices via Electrohydrodynamic Micro-Scale Printing.  ADVANCED ENGINEERING MATERIALS,  21  (10): (1900699).  [PMID:] [10.1002/adem.201900699]

Solution Calculators