Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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L276132-1g | 1g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $16.90 | |
L276132-5g | 5g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $62.90 | |
L276132-10g | 10g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $99.90 | |
L276132-25g | 25g | In stock | $222.90 | |
L276132-100g | 100g | In stock | $710.90 |
Voltage gated sodium channel blocker
Synonyms | Rucaina hydrochloride | Xilina hydrochloride | Xyloneural | Lidocaine hydrochloride | Lidothesin | Xycaine hydrochloride | LARYNG-O-JET | Anestacon | Xylocaine Viscous | Duncaine hydrochloride | Lidothesin hydrochloride | Xylotox hydrochloride | LIDOCAINE |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | Voltage gated sodium channel blocker (IC 50 values are 42 and 210 μM for TTX-sensitive and TTX-resistant DRG channels respectively). Reduces proinflammatory cytokine production and shows anesthetic effects in vivo. |
Storage Temp | Protected from light,Store at -20°C,Desiccated |
Shipped In | Ice chest + Ice pads |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Lidocaine hydrochloride (Lignocaine hydrochloride) inhibits sodium channels involving complex voltage and using dependence. Lidocaine hydrochloride decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine hydrochloride is an amide derivative and a agent to treat ventricular arrhythmia and an effective tumor-inhibitor. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide;hydrochloride |
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INCHI | InChI=1S/C14H22N2O.ClH/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4;/h7-9H,5-6,10H2,1-4H3,(H,15,17);1H |
InChi Key | IYBQHJMYDGVZRY-UHFFFAOYSA-N |
Canonical SMILES | CCN(CC)CC(=O)NC1=C(C=CC=C1C)C.Cl |
Isomeric SMILES | CCN(CC)CC(=O)NC1=C(C=CC=C1C)C.Cl |
PubChem CID | 6314 |
Molecular Weight | 270.8 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
L2410509 | Certificate of Analysis | Dec 13, 2024 | L276132 |
H2402016 | Certificate of Analysis | Aug 09, 2024 | L276132 |
C2421038 | Certificate of Analysis | Apr 01, 2024 | L276132 |
F2421069 | Certificate of Analysis | Apr 01, 2024 | L276132 |
C2421489 | Certificate of Analysis | Mar 02, 2024 | L276132 |
C2421490 | Certificate of Analysis | Mar 02, 2024 | L276132 |
C2421491 | Certificate of Analysis | Mar 02, 2024 | L276132 |
C2421492 | Certificate of Analysis | Mar 02, 2024 | L276132 |
K2127605 | Certificate of Analysis | Jun 14, 2023 | L276132 |
H2211325 | Certificate of Analysis | May 12, 2023 | L276132 |
H2211328 | Certificate of Analysis | May 12, 2023 | L276132 |
H2211329 | Certificate of Analysis | May 12, 2023 | L276132 |
J2307026 | Certificate of Analysis | May 12, 2023 | L276132 |
K2127609 | Certificate of Analysis | Sep 09, 2022 | L276132 |
D2306120 | Certificate of Analysis | Jun 13, 2022 | L276132 |
E2224202 | Certificate of Analysis | May 27, 2022 | L276132 |
Solubility | Soluble in water to 100 mM |
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Sensitivity | light & Moisture sensitive |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H302:Harmful if swallowed |
Precautionary Statements | P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P312:IF SWALLOWED: call a POISON CENTER/doctor/... IF you feel unwell. |
Starting at $69.90
1. Quanpeng Li, Xueqing Yu, Xiaoyan Zheng, Jing Yang, Junfeng Hui, Daidi Fan. (2024) Rapid dissolution microneedle based on polyvinyl alcohol/chitosan for local oral anesthesia. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 257 (128629). [PMID:38070795] [10.1016/j.ijbiomac.2023.128629] |
2. Xiaokang Guan, Qiao Lu, Xiangxu Zhao, Xiaowen Yan, Renato Zenobi. (2023) Spatio-Temporal Analysis of Anesthetics in Mice by Solid-Phase Microextraction: Dielectric Barrier Discharge Ionization Mass Spectrometry. ANALYTICAL CHEMISTRY, 95 (33): (12470–12477). [PMID:37560898] [10.1021/acs.analchem.3c02123] |
3. Wenjie Xu, Yu Xiao, Minzhi Zhao, Jiahui Zhu, Yu Wang, Wenbin Wang, Peng Wang, Huan Meng. (2023) Effective Treatment of Knee Osteoarthritis Using a Nano-Enabled Drug Acupuncture Technology in Mice. Advanced Science, (2302586). [PMID:37555294] [10.1002/advs.202302586] |
4. Yang Yang, Sun Jiaxiao, Peng Fei, Liu Haibei, Zhao Guoyan, Chen Junjie, Zhang Wensheng, Qiu Feng. (2022) Enhanced Antitumor Activity of Lidocaine Nanoparticles Encapsulated by a Self-Assembling Peptide. Frontiers in Pharmacology, 13 [PMID:35529446] [10.3389/fphar.2022.770892] |
5. Baolin Wang, Xing Chen, Zeeshan Ahmad, Jie Huang, Ming-Wei Chang. (2019) Engineering On-Demand Magnetic Core–Shell Composite Wound Dressing Matrices via Electrohydrodynamic Micro-Scale Printing. ADVANCED ENGINEERING MATERIALS, 21 (10): (1900699). [PMID:] [10.1002/adem.201900699] |
1. Quanpeng Li, Xueqing Yu, Xiaoyan Zheng, Jing Yang, Junfeng Hui, Daidi Fan. (2024) Rapid dissolution microneedle based on polyvinyl alcohol/chitosan for local oral anesthesia. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 257 (128629). [PMID:38070795] [10.1016/j.ijbiomac.2023.128629] |
2. Xiaokang Guan, Qiao Lu, Xiangxu Zhao, Xiaowen Yan, Renato Zenobi. (2023) Spatio-Temporal Analysis of Anesthetics in Mice by Solid-Phase Microextraction: Dielectric Barrier Discharge Ionization Mass Spectrometry. ANALYTICAL CHEMISTRY, 95 (33): (12470–12477). [PMID:37560898] [10.1021/acs.analchem.3c02123] |
3. Wenjie Xu, Yu Xiao, Minzhi Zhao, Jiahui Zhu, Yu Wang, Wenbin Wang, Peng Wang, Huan Meng. (2023) Effective Treatment of Knee Osteoarthritis Using a Nano-Enabled Drug Acupuncture Technology in Mice. Advanced Science, (2302586). [PMID:37555294] [10.1002/advs.202302586] |
4. Yang Yang, Sun Jiaxiao, Peng Fei, Liu Haibei, Zhao Guoyan, Chen Junjie, Zhang Wensheng, Qiu Feng. (2022) Enhanced Antitumor Activity of Lidocaine Nanoparticles Encapsulated by a Self-Assembling Peptide. Frontiers in Pharmacology, 13 [PMID:35529446] [10.3389/fphar.2022.770892] |
5. Baolin Wang, Xing Chen, Zeeshan Ahmad, Jie Huang, Ming-Wei Chang. (2019) Engineering On-Demand Magnetic Core–Shell Composite Wound Dressing Matrices via Electrohydrodynamic Micro-Scale Printing. ADVANCED ENGINEERING MATERIALS, 21 (10): (1900699). [PMID:] [10.1002/adem.201900699] |