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Lifitegrast - 10mM in DMSO, high purity , CAS No.1025967-78-5
LFA-1 (lymphocyte function-associated antigen-1) antagonist
Basic Description Synonyms Lifitegrast | 1025967-78-5 | Xiidra | SAR 1118 | SAR-1118 | SHP606 | SHP-606 | (S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid | UNII-038E5L962W | 038E5L962W | CHEMBL2048028 | CHEBI:133023 | D Specifications & Purity Moligand™, 10mM in DMSO Biochemical and Physiological Mechanisms LFA-1 (lymphocyte function-associated antigen-1) antagonist, used to treat ocular vascular complications. Lifitegrast\xa0 is a new type of T cell integrin antagonist designed to mimic the binding epitope of ICAM-1.
Storage Temp Store at -80°C Shipped In Ice chest + Ice pads Grade Moligand™ Product Description LFA-1 (lymphocyte function-associated antigen-1) antagonist.
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name (2S)-2-[[2-(1-benzofuran-6-carbonyl)-5,7-dichloro-3,4-dihydro-1H-isoquinoline-6-carbonyl]amino]-3-(3-methylsulfonylphenyl)propanoic acid INCHI InChI=1S/C29H24Cl2N2O7S/c1-41(38,39)20-4-2-3-16(11-20)12-23(29(36)37)32-27(34)25-22(30)13-19-15-33(9-7-21(19)26(25)31)28(35)18-6-5-17-8-10-40-24(17)14-18/h2-6,8,10-11,13-14,23H,7,9,12,15H2,1H3,(H,32,34)(H,36,37)/t23-/m0/s1 InChi Key JFOZKMSJYSPYLN-QHCPKHFHSA-N Canonical SMILES CS(=O)(=O)C1=CC=CC(=C1)CC(C(=O)O)NC(=O)C2=C(C=C3CN(CCC3=C2Cl)C(=O)C4=CC5=C(C=C4)C=CO5)Cl Isomeric SMILES CS(=O)(=O)C1=CC=CC(=C1)C[C@@H](C(=O)O)NC(=O)C2=C(C=C3CN(CCC3=C2Cl)C(=O)C4=CC5=C(C=C4)C=CO5)Cl PubChem CID 11965427 Molecular Weight 615.48
Safety and Hazards(GHS) Pictogram(s) GHS08 Signal Warning Hazard Statements H361: Suspected of damaging fertility or the unborn child
Precautionary Statements P280: Wear protective gloves/protective clothing/eye protection/face protection.
P405: Store locked up.
P501: Dispose of contents/container to ...
P203: Obtain, read and follow all safety instructions before use.
P318: if exposed or concerned, get medical advice.
Citations of This Product 1. Xin Meng, Ye Wang. (2021) Drug Repurposing for Influenza Virus Polymerase Acidic (PA) Endonuclease Inhibitor. MOLECULES, 26 (23): (7326). [PMID:34885905 ] [10.3390/molecules26237326 ]
References 1. Xin Meng, Ye Wang. (2021) Drug Repurposing for Influenza Virus Polymerase Acidic (PA) Endonuclease Inhibitor. MOLECULES, 26 (23): (7326). [PMID:34885905 ] [10.3390/molecules26237326 ]
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