LIMK1 inhibitor BMS-4 is a LIM Kinase (LIMK) inhibitor targeting to LIMK1/2. LIMK1 inhibitor BMS-4 inhibits phosphorylation of cofilin, the LIMK substrate. However, LIMK1 inhibitor BMS-4 is noncytotoxic on A549 cells.
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Shipped In
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Product Description
LIMK1 inhibitor BMS-4 is a LIM Kinase (LIMK) inhibitor targeting to LIMK1/2. LIMK1 inhibitor BMS-4 inhibits phosphorylation of cofilin, the LIMK substrate. However, LIMK1 inhibitor BMS-4 is noncytotoxic on A549 cells.
In Vitro
LIMK1 inhibitor BMS-4 (compound 4) (0.014-10 μM; 24 h) inhibits LIMKs in vitro without affecting A549 cell survival or proliferation. LIMK1 inhibitor BMS-4 (0.014-1 μM; 2 h) inhibits phosphorylation of the LIMK substrate cofilin in A549 human lung cancer cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
