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Lin28 1632 - ≥98%(HPLC), high purity , CAS No.108825-65-6

≥98%(HPLC)

CAS#: 108825-65-6
Formula: C₁₅H₁₅N₅O
Molecular Weight: 281.31
PubChem CID: 2737312
PubChem SID: 488192879

Item Number

L287258

Grouped product items
SKU	Size	Availability	Price
L287258-5mg	5mg	In stock	$107.90
L287258-10mg	10mg	In stock	$165.90
L287258-25mg	25mg	In stock	$371.90
L287258-50mg	50mg	In stock	$711.90
L287258-100mg	100mg	In stock	$1,280.90
L287258-250mg	250mg	In stock	$2,881.90

RNA binding protein Lin28 inhibitor; promotes mESC differentiation; also bromodomain inhibitor

Basic Description

Synonyms	Lin28 1632 \| Lin-28 1632 \| N-methyl-N-[3-(3-methyl-1,2,4-triazolo[4,3-b]-pyridazin-6-yl)phenyl]acetamide \| N-Methyl-N-[3-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]acetamide \| CCG-42206 \| DTXSID20371981 \| HMS1448E05 \| Lin281632 \| Lin-281632 \| WP
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	RNA binding protein Lin28 inhibitor (IC50= 8μM). Blocks binding of Lin28 to let-7 pre-micro RNA. Inhibits stemness and induces differentiation of murine ESCs. Increaseslet-7miRNA and suppresses PD-L1 expression in multiple human cancer cell lines. Inhibit
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	Product Describtion: Lin28-let-7 antagonist 1 (compound 1632) is a potent antagonist of Lin28/pre-let-7 interaction. Lin28-let-7 antagonist 1 inhibits Lin28A binding to pre-let-7a-2, with an IC50 of 8 μM. Lin28-let-7 antagonist 1 inhibits proliferation in human cancer cells.

Associated Targets(Human)

BRD4 Tchem Bromodomain-containing protein 4 (13122 Activities)

Discover Target: BRD4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 Activities)

Discover Target: ATAD5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)

Discover Target: Txnrd1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Lin28a Protein lin-28 homolog A (33 Activities)

Discover Target: Lin28a

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

Pubchem Sid	488192879
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488192879
IUPAC Name	N-methyl-N-[3-(3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)phenyl]acetamide
INCHI	InChI=1S/C15H15N5O/c1-10-16-17-15-8-7-14(18-20(10)15)12-5-4-6-13(9-12)19(3)11(2)21/h4-9H,1-3H3
InChi Key	WPAQLESUVYGUJZ-UHFFFAOYSA-N
Canonical SMILES	CC1=NN=C2N1N=C(C=C2)C3=CC(=CC=C3)N(C)C(=O)C
Isomeric SMILES	CC1=NN=C2N1N=C(C=C2)C3=CC(=CC=C3)N(C)C(=O)C
PubChem CID	2737312
Molecular Weight	281.31

Certificates

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12 results found

Lot Number	Certificate Type	Date	Item
D2325541	Certificate of Analysis	Mar 25, 2023	L287258
D2325549	Certificate of Analysis	Mar 25, 2023	L287258
D2325550	Certificate of Analysis	Mar 25, 2023	L287258
D2325552	Certificate of Analysis	Mar 25, 2023	L287258
D2325553	Certificate of Analysis	Mar 25, 2023	L287258
D2325554	Certificate of Analysis	Mar 25, 2023	L287258
D2325555	Certificate of Analysis	Mar 25, 2023	L287258
D2325559	Certificate of Analysis	Mar 25, 2023	L287258
D2325560	Certificate of Analysis	Mar 25, 2023	L287258
D2325561	Certificate of Analysis	Mar 25, 2023	L287258
D2325563	Certificate of Analysis	Mar 25, 2023	L287258
D2325564	Certificate of Analysis	Mar 25, 2023	L287258

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