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SKU | Size | Availability | Price | Qty |
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L413361-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $19.90 | |
L413361-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $68.90 | |
L413361-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $110.90 | |
L413361-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $199.90 | |
L413361-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $323.90 |
Specifications & Purity | ≥98% |
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Biochemical and Physiological Mechanisms | LIN28 inhibitor LI71 is a potent and cell-permeable inhibitor of LIN28, which abolishes LIN28-mediated oligouridylation with IC50 of 7 μM. LIN28 inhibitor LI71 directly binds the cold shock domain (CSD) to suppress LIN28's activity against let-7 in leukem |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Product Description | Information LIN28 inhibitor LI71 is a potent and cell-permeable inhibitor of LIN28, which abolishes LIN28-mediated oligouridylation with IC50 of 7 μM. LIN28 inhibitor LI71 directly binds the cold shock domain (CSD) to suppress LIN28's activity against let-7 in leukemia cells and embryonic stem cells. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 4-[(3aS,4R,9bR)-6-ethoxy-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]benzoic acid |
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INCHI | InChI=1S/C21H21NO3/c1-2-25-18-8-4-7-17-15-5-3-6-16(15)19(22-20(17)18)13-9-11-14(12-10-13)21(23)24/h3-5,7-12,15-16,19,22H,2,6H2,1H3,(H,23,24)/t15-,16+,19+/m1/s1 |
InChi Key | QWJMABCFVYELBB-GJYPPUQNSA-N |
Canonical SMILES | CCOC1=CC=CC2=C1NC(C3C2C=CC3)C4=CC=C(C=C4)C(=O)O |
Isomeric SMILES | CCOC1=CC=CC2=C1N[C@H]([C@@H]3[C@H]2C=CC3)C4=CC=C(C=C4)C(=O)O |
PubChem CID | 6541811 |
Molecular Weight | 335.4 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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B2423191 | Certificate of Analysis | Jan 12, 2024 | L413361 |
B2423192 | Certificate of Analysis | Jan 12, 2024 | L413361 |
B2423193 | Certificate of Analysis | Jan 12, 2024 | L413361 |
B2423194 | Certificate of Analysis | Jan 12, 2024 | L413361 |
B2423195 | Certificate of Analysis | Jan 12, 2024 | L413361 |
B2423214 | Certificate of Analysis | Jan 12, 2024 | L413361 |
B2423215 | Certificate of Analysis | Jan 12, 2024 | L413361 |
B2423216 | Certificate of Analysis | Jan 12, 2024 | L413361 |
B2423217 | Certificate of Analysis | Jan 12, 2024 | L413361 |